9 patents
Utility
Lipid Formulations for Gene Editing
11 Jan 24
The present disclosure relates to PEG-lipids, cationic and/or ionizable lipids and nucleic acid-lipid particle compositions comprising the same.
Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Aaron Beach, Thomas V., Colace
Filed: 8 Mar 23
Utility
Hybridized Guide Nucleic Acids for Use with Template-based Gene Editors
11 Jan 24
Polynucleotides are engineered to hybridize to one another to form a functional guide nucleic acid having an editing template.
Vidya Subramanian, Kallanthottathil G. Rajeev, Hariharan Jayaram, Caroline Reiss, Maryam Habibian, Gitali Devi, Allison Baker
Filed: 7 Jul 23
Utility
Compositions and methods for targeted RNA delivery
31 Oct 23
Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9.
Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
Filed: 23 Nov 21
Utility
Compositions and Methods for Capping Rnas
19 Oct 23
Provided herein are compositions and methods for preparation of 5′ end region-modified mRNAs.
Christopher Cheng, Kallanthottathil Rajeev, Caroline Reiss, Kui Wang, Athul Sanjeev
Filed: 1 Mar 23
Utility
Chemically Modified Guide Rnas for Genome Editing with CAS9
25 May 23
Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions.
Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
Filed: 9 Apr 21
Utility
Base Editing of PCSK9 and Methods of Using Same for Treatment of Disease
25 May 23
Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions.
Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
Filed: 9 Apr 21
Utility
Chemically Modified Guide Rnas for Genome Editing with CAS12B
4 May 23
Provided herein are compositions related to Cas12b guide RNAs.
Kallanthottathil G. Rajeev, Alexandra Chadwick, Caroline Reiss
Filed: 9 Apr 21
Utility
Compositions and methods for targeted RNA delivery
28 Dec 21
Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9.
Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
Filed: 4 Mar 21
Utility
Compositions and Methods for Targeted Rna Delivery
30 Sep 21
Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9.
Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
Filed: 4 Mar 21
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