22 patents
Utility
HDAC6 Inhibitors for Treatment of Metabolic Disease and Hfpef
30 Nov 23
Provided herein are methods of treating or preventing metabolic disease with an HDAC6 inhibitor.
Jin YANG, Mohammad A. MANDEGAR, Timothy C. HOEY
Filed: 27 Jul 23
Utility
Gene Therapy Vectors for Treating Heart Disease
23 Nov 23
The present disclosure provides methods and compositions useful for the treatment or prevention of heart disease.
Laura LOMBARDI
Filed: 28 Jul 23
Utility
PLAKOPHILLIN-2 Gene Therapy Methods and Compositions
19 Oct 23
Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).
Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
Filed: 7 Apr 23
Utility
Plakophillin-2 gene therapy methods and compositions
10 Oct 23
Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).
Zhihong Jane Yang, Jaclyn Ho, Chris Reid, Jin Yang
Filed: 30 Jul 21
Utility
Gene therapy vectors for treating heart disease
19 Sep 23
The present disclosure provides methods and compositions useful for the treatment or prevention of heart disease.
Laura Lombardi
Filed: 21 Jan 22
Utility
Adeno-associated Virus with Engineered Capsid
13 Jul 23
The present disclosure provides recombinant adeno-associated virus (rAAV) virions with an engineered capsid protein.
Ze CHENG, Christopher A. REID
Filed: 19 Apr 21
Utility
Fluoroalkyl-oxadiazoles and Uses Thereof
11 May 23
Provided herein are compounds identified as inhibitors of HDAC6 activity that can be used to treat various diseases and disorders.
Snahel PATEL, Mohammad A. MANDEGAR, David SPERANDIO, Julio MEDINA, Ulhas BHATT, Alok NERUKAR, Tien WIDJAJA
Filed: 23 Dec 22
Utility
Optimized Expression Cassettes for Gene Therapy
4 May 23
In some aspects, cardiac-specific expression cassettes are provided herein.
Huanyu ZHOU, Christopher A. REID
Filed: 8 Jul 22
Utility
Cardiac Cell Reprogramming with Micrornas and Other Factors
4 May 23
The present disclosure provides methods for generating induced cardiomyocytes by expression of selected microRNAs with MYOCD and ASCL1, or with MYOCD alone.
Huanyu ZHOU, Chetan SRINATH, Timothy HOEY
Filed: 10 Jul 20
Utility
5-FLUORONICOTINAMIDE Derivatives and Uses Thereof
20 Apr 23
Mohammad A. MANDEGAR, Snahel PATEL, Ulhas BHATT, Pingyu DING, Martin HOLAN, John LEE, Yihong LI, Julio MEDINA, Alok NERURKAR, Frederick SEIDL, David SPERANDIO, Tien WIDJAJA, Xiaodong WANG
Filed: 4 Apr 22
Utility
Gene Vector Control by Cardiomyocyte-expressed Micrornas
6 Apr 23
The present disclosure provides vectors and method of use thereof, for cell-type specific repression of expression of transgenes (e.g., cardiomyocyte reprogramming factors) using microRNA binding sites.
Laura LOMBARDI, Elena C. LEON, Tawny Neal QURESHI, Kathryn N. IVEY
Filed: 26 Feb 21
Utility
PLAKOPHILLIN-2 Gene Therapy Methods and Compositions
23 Feb 23
Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).
Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
Filed: 5 Aug 22
Utility
PLAKOPHILLIN-2 Gene Therapy Methods and Compositions
16 Feb 23
Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).
Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
Filed: 6 Oct 22
Utility
Fluoroalkyl-oxadiazoles and uses thereof
14 Feb 23
Snahel Patel, Mohammad A. Mandegar, David Sperandio, Julio Medina, Ulhas Bhatt, Alok Nerurkar, Tien Widjaja
Filed: 28 Apr 22
Utility
PLAKOPHILLIN-2 Gene Therapy Methods and Compositions
9 Feb 23
Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).
Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
Filed: 5 Aug 22
Utility
Gene therapy vectors for treating heart disease
20 Sep 22
The present disclosure provides methods and compositions useful for the treatment or prevention of heart disease.
Laura Lombardi
Filed: 21 Oct 21
Utility
Gene Therapy Vectors for Treating Heart Disease
26 May 22
The present disclosure provides methods and compositions useful for the treatment or prevention of heart disease.
Laura LOMBARDI
Filed: 21 Jan 22
Utility
PLAKOPHILLIN-2 Gene Therapy Methods and Compositions
14 Apr 22
Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).
Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
Filed: 30 Jul 21
Utility
Gene Therapy Vectors for Treating Heart Disease
3 Feb 22
The present disclosure provides methods and compositions useful for the treatment or prevention of heart disease.
Laura LOMBARDI
Filed: 21 Oct 21
Utility
Gene Therapy Vectors for Treating Heart Disease
11 Nov 21
The present disclosure provides methods and compositions useful for the treatment or prevention of heart disease.
Laura LOMBARDI
Filed: 22 Jul 21