13 patents
Utility
PCSK9 endonuclease variants, compositions, and methods of use
10 Oct 23
The present disclosure provides improved genome editing compositions and methods for editing a PCSK9 gene.
Jordan Jarjour, Kyle Havens, Michael Certo, Max Echterling
Filed: 4 Oct 18
Utility
CBLB endonuclease variants, compositions, and methods of use
22 Aug 23
The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene.
Jordan Jarjour, Kyle Havens, Anne-Rachel Krostag
Filed: 15 Jan 21
Utility
TGFBeta signal convertor
23 May 23
The present disclosure provides improved compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
Benjamin Boyerinas
Filed: 17 Nov 17
Utility
BCMA chimeric antigen receptors
25 Apr 23
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 1 Apr 20
Utility
TCRα homing endonuclease variants
28 Feb 23
The present disclosure provides improved genome editing compositions and methods for editing a TCRα gene.
Jordan Jarjour, Mark Pogson
Filed: 11 Oct 17
Utility
Methods of making T cell compositions
24 Jan 23
The invention provides improved T cell compositions and methods for manufacturing T cells.
Kevin Friedman
Filed: 9 Oct 19
Utility
Multipartite signaling proteins and uses thereof
20 Dec 22
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
Jordan Jarjour, Alexander Astrakhan, Michael Certo
Filed: 17 Sep 19
Utility
TGFBetaR2 endonuclease variants, compositions, and methods of use
20 Dec 22
The present disclosure provides improved genome editing compositions and methods for editing a TGFβR2 gene.
Jordan Jarjour, Kyle Havens
Filed: 17 Oct 17
Utility
Donor repair templates multiplex genome editing
15 Nov 22
The present disclosure provides improved multiplex genome editing compositions and methods.
Baeckseung Lee, Alexander Astrakhan
Filed: 15 Feb 18
Utility
T cell compositions
25 Oct 22
The invention provides improved T cell compositions and methods for manufacturing T cells.
Kevin Friedman
Filed: 7 Dec 15
Utility
BCMA chimeric antigen receptors
12 Jul 22
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 23 Oct 20
Utility
PD-1 homing endonuclease variants, compositions, and methods of use
21 Jun 22
The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene.
Jasdeep Mann, Joel Gay, Jordan Jarjour, Joy Zhang
Filed: 8 Sep 17
Utility
BCMA chimeric antigen receptors
7 Jun 22
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 23 Oct 20
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