933 patents
Utility
Modified Imidazopyridines As Glucosylceramide Synthase Inhibitors
18 Jan 24
Melissa C. Ford, Mark E. Fraley, Kristen L.G. Jones, H. Marie Loughran, James J. Mulhearn, Anthony J. Roecker, Kathy M. Schirripa, Ling Tong
Filed: 15 Sep 21
Utility
Polycyclic Cap-dependent Endonuclease Inhibitors for Treating or Preventing Influenza
18 Jan 24
Yonglian Zhang, John A. McCauley, Michael Man-Chu Lo, Liangqin Guo, Kake Zhao, Frank Bennett, Ronald M. Kim, Reynalda Keh DeJesus, Valerie W. Shurtleff, Manuel de Lera Ruiz, Michael Plotkin, Hua Su, James Fells, Brendan M. Crowley, Harry R. Chobanian, Mark W. Embrey, Gregori J. Morriello
Filed: 22 Jul 21
Utility
Well plate assembly with pressure release mechanism
16 Jan 24
A well plate assembly with an interior channel system in the well plate lid provides a more efficient and uniform distribution of fluid into a receptacle positioned below the well plate lid.
Tinh Nguyen-DeMary, William James Ciolino
Filed: 14 Jul 22
Utility
Densified Co-precipitated Materials Isolated by Thin Film Evaporation
11 Jan 24
The invention encompasses a process for densifying co-precipitated material comprised of an active pharmaceutical ingredient and at least one stabilizing excipient using thin film evaporation, and the densified co-precipitates made thereby.
Derek S. Frank, Haichen Nie, Luke Ryan Schenck, Jasmine M. Rowe
Filed: 7 Jul 23
Utility
Combination Vaccine for Protecting Swine Against Various Disorders
11 Jan 24
The present invention pertains to a vaccine comprising in combination non-replicating immunogen of porcine circo virus type 2 (PCV2), non-replicating immunogen of Mycoplasma hyopneumoniae and conjugated deoxynivalenol (DON) for protecting swine against an infection with porcine circo virus type 2, an infection with Mycoplasma hyopneumoniae and DON induced mycotoxicosis.
Sietske Kooijman, Ruud Philip Antoon Maria Segers, Maarten Hendrik Witvliet
Filed: 28 Oct 21
Utility
Novel Synthetic Pathway to Belzutifan
11 Jan 24
Daniel A. DiRocco, Jackson Kenai Blender Cahn, Wai Ling Cheung-Lee, Stephanie W. Chun, J. Caleb Hethcox, Heather Claire Johnson, Jungchul Kim, Joshua N. Kolev, Birgit Kosjek, Diane Le, Scott D. McCann, John McIntosh, Jonathan P. McMullen, Jeffrey C. Moore, William Morris, Juan Esteban Velasquez Velez, Matthew S. Winston, Victoria Zhang, Yong-Li Zhong
Filed: 3 Jul 23
Utility
Compositions and Methods for Treating Cancer with a Combination of an Antagonist of PD-1 and an ANTI-CTLA4 Antibody
11 Jan 24
The present invention relates to methods for treating cancer comprising administering an antagonist of PD-1, e.g., anti-PD-1 antibody or antigen binding fragment thereof, and an anti-CTLA4 antibody or antigen binding fragment thereof, wherein the CTLA4 antibody or antigen binding fragment thereof is given at a fixed dose.
Blanca Homet Moreno, Nageatte Ibrahim, Scot W. Ebbinghaus, Lokesh Jain, Scott Diede
Filed: 12 Dec 22
Utility
Full-length Human Immunoglobulin G Antibody Libraries for Surface Display and Secretion In Saccharomyces Cerevisiae
11 Jan 24
A Saccharomyces cerevisiae antibody display system that simultaneously secrets and displays antibody fragments from a very large size synthetic nave human antibody library for therapeutic antibody lead discovery and engineering is described.
Michelle Castor, Ming-Tang Chen, Chung-Ming Hsieh
Filed: 18 Nov 21
Utility
Combination Therapy of a PD-1 Antagonist and LAG3 Antagonist and Lenvatinib or a Pharmaceutically Acceptable Salt Thereof for Treating Patients with Cancer
11 Jan 24
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1), a Lymphocyte-Activation Gene 3 (LAG3) antagonist, and lenvatinib or a pharmaceutically acceptable salt thereof and the use of the combination therapies for the treatment cancer.
Jane Anne Healy, Sujata Shrawankuma Jha, Patricia Marinello, Rodolfo Fleury Perini, Jaqueline Willemann Rogerio
Filed: 14 Sep 21
Utility
Increased Voltage-gated Sodium Channel Alpha Protein Subunit Expression Through Viral 2A-MEDIATED Co-expression of Nav Beta Subunits
11 Jan 24
A voltage-gated sodium channel expression system is described.
Richard L. Kraus, John Majercak
Filed: 12 Nov 21
Utility
Livestock dry off method and device
9 Jan 24
A system and method for automatically drying-off a machine-milked dairy animal by controlling milk production during a gradual drying-off period.
Rotem Rabinovitz
Filed: 10 Oct 19
Utility
Sterile line clip separation tool
9 Jan 24
A system and a method are disclosed for disconnecting clips.
Derrick Matthew Smith
Filed: 21 Jul 20
Utility
Compact Containment System for Isolating, Processing and Packaging Pharmaceutical Products
4 Jan 24
A compact containment system comprises a mixing apparatus, a drying apparatus and a discharge apparatus.
John H. Roosa, Alan S. D'Alessandro, Frank D. Gianotti, III, Robert C. O'Connor, Luke Ryan Schenck, Timothy Stanoch, Matthew Yuhas, JR.
Filed: 2 Dec 21
Utility
a Method of Treating Foot Rot
4 Jan 24
The subject invention is the novel use of an injectable pharmaceutical composition comprising tildipirosin for the treatment and prophylaxis of foot rot.
Luis Fernando Vettorato, Mauricio Marques De Morais, Rafael Marin Chiummo, Heitor De Oliveira Arriero Amaral
Filed: 2 Dec 21
Utility
Recombinant Vectors Encoding Chimeric Coronavirus Spike Proteins and Use Thereof
4 Jan 24
The present invention provides recombinant vectors encoding a chimeric coronavirus spike protein.
Martijn Alexander Langereis, Ad De Groof, Paul Vermeij, Berend Jan Bosch
Filed: 11 Nov 21
Utility
3-HETEROARYL Pyrrolidine and Piperidine Orexin Receptor Agonists
4 Jan 24
The present invention is directed to 3-heteroaryl pyrrolidine and piperidine compounds which are agonists of orexin receptors.
Stephane L. Bogen, Ping Chen, Dane James Claussen, Xianhai Huang, Michael T. Rudd, Shawn P. Walsh, Lan Wei, Dexi Yang
Filed: 1 Dec 21
Utility
Mesothelioma Gene Therapy
4 Jan 24
The present invention provides a method for the treatment of lung cancer through the use of a recombinant gene therapy vector having a transgene encoding interferon.
William F. BENEDICT
Filed: 15 Sep 23
Utility
3-AMINO Pyrrolidine and Piperidine Macrocyclic Orexin Receptor Agonists
4 Jan 24
The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors.
Stephane L. Bogen, Ping Chen, Dane James Clausen, Jian Liu, Michael T. Rudd, Li Xiao, Dexi Yang, Shishi Lin
Filed: 18 Nov 21
Utility
NAV1.7 Binders
4 Jan 24
Antibodies and antigen-binding fragments thereof that bind the human voltage-gated sodium channel Nav1.7α protein subunit (Nav1.7 binders) are described.
Pravien Damitha Abeywickrema, Erik Depla, Bruno Dombrecht, Daniel M. Gorman, Andrea K. Houghton, Robert A. Kastelein, Richard L. Kraus, John Majercak, Kalyan Pande, Sujata Sharma
Filed: 18 Nov 21
Utility
Caninized Rat Antibodies to Canine INTERLEUKIN-31 Receptor Alpha
4 Jan 24
The present invention provides caninized rat antibodies to canine IL-31 receptor alpha that have a high binding affinity for canine EL-31 receptor alpha, and that can block the binding of canine IL-31 to canine EL-31 receptor alpha.
Mohamad Morsey, Yuanzheng Zhang, Anasuya Saha
Filed: 14 Oct 21