933 patents
Page 2 of 47
Utility
NAV1.7 Binders
4 Jan 24
Antibodies and antigen-binding fragments thereof that bind the human voltage-gated sodium channel Nav1.7α protein subunit (Nav1.7 binders) are described.
Pravien Damitha Abeywickrema, Erik Depla, Bruno Dombrecht, Daniel M. Gorman, Andrea K. Houghton, Robert A. Kastelein, Richard L. Kraus, John Majercak, Kalyan Pande, Sujata Sharma
Filed: 18 Nov 21
Utility
Caninized Rat Antibodies to Canine INTERLEUKIN-31 Receptor Alpha
4 Jan 24
The present invention provides caninized rat antibodies to canine IL-31 receptor alpha that have a high binding affinity for canine EL-31 receptor alpha, and that can block the binding of canine IL-31 to canine EL-31 receptor alpha.
Mohamad Morsey, Yuanzheng Zhang, Anasuya Saha
Filed: 14 Oct 21
Utility
Arginase 1 Binders for Inhibiting Arginase 1 Activity
4 Jan 24
Arginase 1 binders comprising human antibodies and antigen-binding fragments thereof that inhibit the activity of human Arginase 1 (hArg1) are described.
Marc Andre Bailly, Kalyan Chakravarthy, Ghassan Najib Fayad, Laurence Fayadat-Dilman, Veronica Juan, Esther Kofman, Heping Lin, Jennifer E. O'Neil, Rachel Lynn Palte, Giovanna Scapin, Hussam Hisham Shaheen, Tao Wang
Filed: 22 Nov 21
Utility
Apparatus and Method for Collecting Dried Pharmaceutical Product from a Pharmaceutical Drying Device
4 Jan 24
Apparatus and method for collecting a dried pharmaceutical product from a product reservoir of a pharmaceutical drying device, such as a thin film evaporator, while the product reservoir remains under continuous vacuum pressure.
John H. Roosa, Frank D. Gianotti, III, Robert C. O'Connor, Luke Ryan Schenck, Matthew Yuhas, Jr.
Filed: 2 Dec 21
Utility
Chemistry, Manufacturing, and Controls Change Assessment System
4 Jan 24
A user (e.g., a CMC scientist) identifies a change in CMC data for a regulated product, service, or system provided by an organization.
John William Baker, Kyle Hayes, Jose Colon Colon, Regis Antonio Gimenis, Sachin Lalit Doshi, Jacob Rege Klitzke, Michael Bain, Pavlo Dvornikov, Nicolas Rey Turner, Peter Mezensky, Craig Kennedy, Mykyta Viazovskyi, Nikita Vostrosablin, Nirdosh Jagota, Marcy Newquist Huang
Filed: 30 Nov 21
Utility
Process for preparing large size isoxazoline particles
2 Jan 24
The application relates to a process to produce large isoxazoline compound particles which comprises initiating crystallization and then maintaining the temperature of the crystallization in the metastable region by removing, reheating and recycling a portion of the solvent thereby allowing the existing crystals to grow larger while minimizing the formation of newer smaller crystals.
Luke Ryan Schenck, Athanas Koynov, George X. Zhou, Aaron Cote
Filed: 6 Nov 18
Utility
Plasma Kallikrein Inhibitors
28 Dec 23
Anthony Ken Ogawa, Christopher J. Sinz, Jacqueline D. Hicks, Alan C. Cheng, Song Yang, Jianming Bao, Donna A. A. W. Hayes, Simon B. Lang, Maoqun Tian, Salman Jabri, Galen Paul Shearn-Nance, Rongze Kuang, Zhiqiang Zhao, Zhicai Wu
Filed: 9 Sep 21
Utility
Diaminopyrimidine Carboxamide Inhibitors of HPK1
28 Dec 23
Abdelghani Achab, David A. Candito, Anthony Donofrio, Xavier Fradera, Shuhei Kawamura, Samuel M. Levi, Bing Li, Anilkumar G. Nair, Alexander Pasternak, Brandon A. Vara, Elsie C. Yu
Filed: 4 Nov 21
Utility
Methods for Treating Hematologic Malignancies with Amino-pyrrolopyrimidinone Compounds
21 Dec 23
Anson K. Abraham, Mohammed Z. H. Farooqui, Patricia Marinello, Kapil Mayawala
Filed: 2 Nov 21
Utility
Cyclic Peptides for Trapping INTERLEUKIN-1 Beta
21 Dec 23
Faben A. Cruz, Danqing Feng, Zhuyan Guo, Jennifer Hanisak, Jennifer L. Hickey, Charles Lee Jayne, Ahmet Kekec, Michael Man-Chu Lo, Christopher W. Plummer, Elisabetta Bianchi, Stefania Colarusso, Emanuela Nizi, Francesca Pavone, Ali Munaim Yousif
Filed: 13 Jun 23
Utility
Canine Parvovirus
21 Dec 23
The invention relates to a live attenuated parvovirus for use in the protection of an animal against parvovirus infection, wherein the live attenuated parvovirus is administered to the animal as a single dose and is administered during weeks 2-10 of age of the animal.
Jacqueline Pearce
Filed: 3 Nov 21
Utility
7-AZOLE Substituted 2-AMINOQUINAZOLINE Inhibitors of HPK1
21 Dec 23
Joanna L. Chen, Peter H. Fuller, Joey L. Methot, Elsie C. Yu
Filed: 4 Nov 21
Utility
N-linked Isoquinoline Amides As LRRK2 Inhibitors, Pharmaceutical Compositions, and Uses Thereof
21 Dec 23
Peter H. Fuller, Anmol Gulati, Solomon D. Kattar, Mitchell H. Keylor, Kaila A. Margrey, Xin Yan
Filed: 27 Oct 21
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Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies
19 Dec 23
The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various disorders.
Preeti G. Desai, Shuai Shi, Valentyn Antochshuk, Rubi Burlage, Smita Raghava
Filed: 1 May 18
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Anti-respiratory Syncytial Virus (RSV) Antibody Cell-based Potency Assay
14 Dec 23
The disclosure describes methods for measuring the potency of anti-Respiratory Syncytial Virus (RSV) antibody against respiratory syncytial virus in a cell culture system using an RSV reporter virus.
Dai WANG, John P. BILELLO, Kevin B. GURNEY, Ping HAN, Xi HE, Dengyun SUN, Amy Hsu TOU
Filed: 8 Nov 21
Utility
7-PHENYL Substituted 2-AMINOQUINAZOLINE Inhibitors of HPK1
14 Dec 23
David A. Candito, Joanna L. Chen, Anthony Donofrio, Xavier Fradera, Peter H. Fuller, Shuhei Kawamura, Bing Li, Jongwon Lim, Ping Liu, Joey L. Methot, Anilkumar G. Nair, Alexander Pasternak, Brandon A. Vara, Elsie C. Yu
Filed: 4 Nov 21
Utility
Baculovirus Expression Vector
14 Dec 23
The invention concerns a baculovirus expression vector for recombinantly expressing an FMDV capsid precursor protein under control of a promoter, the expression vector comprising a nucleic acid sequence encoding the FMDV capsid precursor protein and the translational enhancers Syn2 land p10UTR.
Amaya Serrano Garcia
Filed: 21 Oct 21
Utility
Method of Treatment of Pain Through Buccal Administration of Flunixin
7 Dec 23
A buccal administration method of flunixin has been developed now to provide an easy to use and effective method of reducing pain in livestock animals (e.g. swine, cattle, sheep, goats, etc.).
Julien Thiry
Filed: 24 Nov 21
Utility
Vaccine for Protection Against Streptococcus Suis
7 Dec 23
The present invention pertains to a vaccine comprising an immunologically effective amount of an IgM protease antigen of Streptococcus suis, for use in a method for protecting pigs against a pathogenic infection with Streptococcus suis by administering the vaccine only once, wherein the vaccine comprises at most 120 μg per dose of the antigen.
Antonius Arnoldus Christiaan Jacobs
Filed: 22 Aug 23
Utility
Baculovirus Expression Vector
7 Dec 23
The invention concerns a baculovirus expression vector for recombinantly expressing a Foot-and-mouth disease virus (FMDV) capsid precursor protein under control of a promoter, the expression vector comprising a nucleic acid sequence encoding the FMDV capsid precursor protein, wherein the ATG start codon of an open reading frame encoding the FMDV capsid precursor protein © is preceded at position −4 to −1 by the nucleic acid sequence 5′-AAAT-3′.
Erwin VAN DEN BORN
Filed: 21 Oct 21