338 patents
Utility
Well plate assembly with pressure release mechanism
16 Jan 24
A well plate assembly with an interior channel system in the well plate lid provides a more efficient and uniform distribution of fluid into a receptacle positioned below the well plate lid.
Tinh Nguyen-DeMary, William James Ciolino
Filed: 14 Jul 22
Utility
Livestock dry off method and device
9 Jan 24
A system and method for automatically drying-off a machine-milked dairy animal by controlling milk production during a gradual drying-off period.
Rotem Rabinovitz
Filed: 10 Oct 19
Utility
Sterile line clip separation tool
9 Jan 24
A system and a method are disclosed for disconnecting clips.
Derrick Matthew Smith
Filed: 21 Jul 20
Utility
Process for preparing large size isoxazoline particles
2 Jan 24
The application relates to a process to produce large isoxazoline compound particles which comprises initiating crystallization and then maintaining the temperature of the crystallization in the metastable region by removing, reheating and recycling a portion of the solvent thereby allowing the existing crystals to grow larger while minimizing the formation of newer smaller crystals.
Luke Ryan Schenck, Athanas Koynov, George X. Zhou, Aaron Cote
Filed: 6 Nov 18
Utility
Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies
19 Dec 23
The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various disorders.
Preeti G. Desai, Shuai Shi, Valentyn Antochshuk, Rubi Burlage, Smita Raghava
Filed: 1 May 18
Utility
Animal tag
5 Dec 23
an animal tag comprising: a one-piece animal tag retaining member made of molded material, having: a first part comprising a female opening connectable to a male member for coupling the animal tag to a body part of an animal; a second part configured to accommodate one or more electronical components capable of obtaining information relating to the animal to which the animal tag is coupled; an intermediate part, located between the first tag part and the second tag part, having a form of a latitudinal recess for enhancing a flexibility of the animal tag.
Mordehay Cohen, Taras Khomitsky, Samy Hazan
Filed: 13 May 21
Utility
System for external fish parasite monitoring in aquaculture
28 Nov 23
A system for external fish parasites monitoring in aquaculture, the system comprising: —a camera (52) suitable to be submerged in a sea pen suitable for containing comprising fish, the camera being arranged for capturing images of the fish; and—an electronic image processing system (86) configured for identifying external fish parasites on the fish by analyzing the captured images, wherein: —a ranging detector (54) configured for detecting the presence of fish and measuring a distance from the detector to the fish is mounted adjacent to the camera (52); and—an electronic control system (12) is arranged to control a focus of the camera (52) on the basis of the measured distance and to trigger the camera (52) when a fish has been detected within a predetermined distance range.
Russel Howe, Zachary Lizer, James Wallace Sarrett, Peter Jon Abrahamson, Jascha Tucker Little
Filed: 19 Dec 18
Utility
Phosphinic amide prodrugs of tenofovir
28 Nov 23
Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase.
Manuel De Lera Ruiz, Izzat Raheem, Michael T. Rudd
Filed: 15 Jul 19
Utility
Human interleukin-2 conjugates biased for the interleukin-2 receptor beta GAMMAc dimer and conjugated to a nonpeptidic, water-soluble polymer
28 Nov 23
Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγc dimer over binding the IL-2 receptor αβγc trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described.
Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
Filed: 20 Apr 21
Utility
Synthetic pathway to belzutifan and crystalline phases of synthetic intermediates
28 Nov 23
Stephen M. Dalby, Clinton Scott Shultz, Chintal Desai, Joshua Lee, Zhiwei Chen, Jungchul Kim, Nastaran Salehi Marzijarani, Tao Wang, Eric M. Phillips, Patrick Larpent, Het P. Patel, Haiheng Guo, Xin Wang, Kangze Dai, Lu Chen, Teng Li, Taotao Lu, Jianjun Duan
Filed: 20 May 22
Utility
Conjugate based systems for controlled insulin delivery
21 Nov 23
The present disclosure provides conjugates that comprise an insulin molecule conjugated via a conjugate framework to two or more separate ligands that each include a saccharide, wherein the framework, ligand, saccharide and insulin molecule optionally comprise a fatty chain (e.g., a C8-30 fatty chain), wherein when said insulin molecule is conjugated both to a C8-30 fatty chain and one or more separate ligands that each include a saccharide, said C8-30 fatty chain is linked to insulin molecule only, and wherein when the framework or ligand comprises a fatty chain the insulin molecule is conjugated to two or more separate ligands.
Lin Yan, Pei Huo, Ahmet Kekec, Danqing D. Feng, Yuping Zhu, Dmitri Pissarnitski, Chris Moyes, Songnian Lin
Filed: 13 Dec 18
Utility
2-oxoimidazolidine-4-carboxamides as NA
31 Oct 23
Ashok Arasappan, Ian M. Bell, Christopher James Bungard, Christopher S. Burgey, Jason M. Cox, Michael J. Kelly, III, Mark E. Layton, Hong Liu, Jian Liu, James J. Perkins, Akshay A. Shah, Michael David VanHeyst, Zhe Wu
Filed: 15 Jun 21
Utility
Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
24 Oct 23
Brendan M. Crowley, Ian M. Bell, Andrew John Harvey
Filed: 5 Mar 21
Utility
Diacylglyceride O-acyltransferase 2 inhibitors
17 Oct 23
Yeon-Hee Lim, Cedric Lorenz Hugelshofer, Victor W. Mak, James Patrick Roane, Jillian R. Sanzone, Samantha E. Shockley, Rose Yen
Filed: 13 May 21
Utility
Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
3 Oct 23
Described are antibody peptide conjugates (APCs) comprising an antibody conjugated to a peptide analog of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have agonist activity at the glucagon (GCG) receptor and the glucagon-like peptide 1 (GLP-1) receptor and the use of such APCs for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
Paul E. Carrington, Grigori Ermakov, Robert M. Garbaccio, Wolfgang Seghezzi, Elisabetta Bianchi, Federica Orvieto, Dennis Gately, Nick Knudsen, Anthony Manibusan
Filed: 27 Aug 20
Utility
Progressively-trained scale-invariant and boundary-aware deep neural network for the automatic 3D segmentation of lung lesions
3 Oct 23
A system and method are disclosed for segmenting a set of two-dimensional CT slices corresponding to a lesion.
Antong Chen, Gregory Goldmacher, Bo Zhou
Filed: 18 Jan 22
Utility
N3-substituted iminopyrimidinones as antimalarial agents
26 Sep 23
Tanweer A. Khan, Jared N. Cumming, David B. Olsen, Justin A. Boddey, Alan F. Cowman, Brad E. Sleebs
Filed: 13 Feb 17
Utility
Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
19 Sep 23
The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR.
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Filed: 24 Jun 22
Utility
Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
19 Sep 23
The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR.
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Filed: 24 Jun 22
Utility
Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
19 Sep 23
The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR.
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Filed: 24 Jun 22