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ENZ Enzo Biochem

APP
Utility
Sphingosine Pathway Modulating Compounds for the Treatment of Coronavirus Infection
23 Sep 21
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
APP
Utility
Sphingosine Pathway Modulating Compounds For The Treatment Of Coronavirus Infection
23 Sep 21
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
APP
Utility
Glucocerebroside Treatment of Disease
26 Aug 21
The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects.
Yaron Ilan, Maya Margalit, Ari Zimran
Filed: 10 Feb 21
GRANT
Utility
Multisignal reagents for labeling analytes
27 Jul 21
Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer.
Jack Coleman, Maciej Szczepanik, Richard Jin
Filed: 28 Nov 18
GRANT
Utility
Affinity tag nucleic acid and protein compositions, and processes for using same
20 Jul 21
The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides.
Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Wayne Patton, Juan Carcamo
Filed: 19 Dec 18
APP
Utility
Affinity Tag Nucleic Acid and Protein Compositions and Processes for Using Same
15 Jul 21
The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides.
Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Wayne Patton, Juan Carcamo, Jack Coleman
Filed: 29 Mar 21
APP
Utility
Sphingosine Kinase Type 1 Inhibitors and Uses Thereof
17 Jun 21
Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.
Sarah SPIEGEL, Robert Elliot ZIPKIN, Jeffrey Kroll ADAMS
Filed: 8 Feb 21
APP
Utility
Sphingosine Pathway Modulating Compounds for the Treatment of Cancers
10 Jun 21
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani, James J. Sonegan
Filed: 19 Nov 20
GRANT
Utility
Multisignal labeling reagents and processes and uses therefor
8 Jun 21
Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group.
Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
Filed: 26 Mar 20
APP
Utility
Antibodies Specific for Sulfation Sites of WNT Pathway Proteins
3 Jun 21
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a.
Joshua Rabbani, James J. Donegan
Filed: 22 Dec 20
APP
Utility
Affinity Tag Nucleic Acid and Protein Compositions and Processes for Using Same
3 Jun 21
The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides.
Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Wayne Patton, Juan Carcamo
Filed: 4 Jan 21
APP
Utility
Fluorescent Dyes and Methods of Use Thereof
18 Mar 21
Zaiguo Li, Praveen Pande
Filed: 19 Nov 20
APP
Utility
Monoazo Dyes with Cyclic Amine As Fluorescence Quenchers
18 Mar 21
The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles.
Zaiguo Li, Praveen Pande, Natarajan Raju
Filed: 2 Nov 20
GRANT
Utility
Sphingosine kinase type 1 inhibitors and uses thereof
16 Mar 21
Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management.
Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
Filed: 10 Mar 20
APP
Utility
Compositions for Preparing Regulatory T-Cell Compositions for the Treatment of Autoimmune Disease
11 Mar 21
The invention provides cell culture compositions for regulatory T-cells that include particular synthetic peptides.
Robert Nussenblatt, Baoying LIU, Lai WEI, Elazar RABBANI, James J. DONEGAN
Filed: 9 Sep 20
GRANT
Utility
Compounds and methods for detection of enzymes that remove methyl succinyl groups from epsilon-amino lysine moieties
16 Feb 21
Konrad T. Howitz, Zhongda Zhang, Anne Kisielewski, Elizabeth Dale, Wayne Forrest Patton
Filed: 30 Mar 20
APP
Utility
Immunomodulatory Compositions and Methods of Use Thereof
11 Feb 21
Provided are immunomodulatory pharmaceutical and non-pharmaceutical compositions that include alpha-synuclein and at least one preselected antigen, such as at least one preselected peptide antigen or immunogen.
Ante Tocilj, Jack Coleman, Elazar Rabbani, James J. Donegan
Filed: 31 Aug 20
GRANT
Utility
Antibodies specific for sulfation sites of sclerostin
26 Jan 21
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a.
Joshua Rabbani, James J. Donegan
Filed: 22 Sep 16
APP
Utility
Dyes for Analysis of Protein Aggregation
14 Jan 21
Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
Wayne Forrest Patton, Sergiy M. Yarmoluk, Praveen Pande, Vladyslava Kovalska, Lijun Dai, Kateryna Volkova, Jack Coleman, Mykhaylo Losytskyy, Anthony Ludlam, Anatoliy Balanda, Dee Shen
Filed: 6 Aug 20
APP
Utility
Sphingosine Pathway Modulating Compounds for the Treatment of Cancers
6 Jan 21
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani, James J. Donegan
Filed: 21 Sep 20
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