77 patents
Page 4 of 4
Utility
Sphingosine pathway modulating compounds for the treatment of cancers
11 May 20
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani, James J. Donegan
Filed: 26 Feb 19
Utility
Compounds and methods for detection of enzymes that remove formyl, succinyl, methyl succinyl or myristoyl groups from epsilon-amino lysine moieties
11 May 20
Konrad T. Howitz, Zhongda Zhang, Anne Kisielewski, Elizabeth Dale, Wayne Forrest Patton
Filed: 17 Apr 19
Utility
Glucocerebroside treatment of disease
4 May 20
The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects.
Yaron Ilan, Maya Margalit, Ari Zimran
Filed: 29 Oct 18
Utility
Multisignal labeling reagents and processes and uses therefor
4 May 20
Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group.
Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
Filed: 20 Dec 17
Utility
Methods and Intermediates for Synthesizing SK1-I
29 Apr 20
The invention provides methods for synthesizing the compound (2R,3S,4E)-N-methyl-5-(4′-pentylphenyl)-2-aminopent-4-ene-1,3-diol, also known as SK1-I, and intermediate compounds used in its synthesis.
Zaiguo Li, Natarajan Raju, Praveen Pande
Filed: 12 May 19
Utility
Multisignal reagents for labeling analytes
20 Apr 20
Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer.
Jack Coleman, Maciej Szczepanik, Richard Jin
Filed: 8 Apr 19
Utility
Sphingosine kinase type 1 inhibitors and uses thereof
20 Apr 20
Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management.
Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
Filed: 16 Sep 19
Utility
Sulfonated sclerostin, antibodies, epitopes and methods for identification and use therefor
20 Apr 20
Provided are antibodies that bind to: a sulfonated epitope of the protein Sclerostin, to Sclerostin portions comprising a sulfonated amino acid and to dimerized forms of Sclerostin.
Joshua Rabbani
Filed: 1 Mar 17
Utility
Diagnosis and Treatment of Viral Diseases
8 Apr 20
Provided are methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient.
Gerard Nuovo, Virginia Nivar
Filed: 14 Oct 19
Utility
Affinity Tag Nucleic Acid and Protein Compositions, and Processes for Using Same
18 Dec 19
The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides.
Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Wayne Patton, Juan Carcamo
Filed: 18 Dec 18
Utility
Diagnosis and treatment of viral diseases
2 Dec 19
This disclosure relates to methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient.
Gerard Nuovo, Virginia Nivar
Filed: 14 Feb 18
Utility
Method for Promoting Wound Healing by Administering a Compound Which Binds Ldl-receptor-related Protein (LRP) Ligand Binding Domain
20 Nov 19
The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors.
Elazar Rabbani, Xiaofeng Li, Dakai Liu, Yazhou Zhang, Richard Jin, Riddhi Bhattacharyya, Wei Cheng, James J. Donegan
Filed: 9 Jun 19
Utility
Methods for Treating Psoriasis
20 Nov 19
The present invention relates to methods for treating psoriasis and other indications by inhibiting leptin activity.
Yaron Ilan, Eran Elinav
Filed: 2 Jun 19
Utility
Compounds and Methods for Detection of Enzymes That Remove Formyl, Succinyl, Methyl Succinyl or Myristoyl Groups from Epsilon-amino Lysine Moieties
6 Nov 19
Konrad T. Horwitz, Zhongda Zhang, Anne Kisielewski, Elizabeth Dale, Wayne Forrest Patton
Filed: 17 Apr 19
Utility
Sphingosine kinase type 1 inhibitors and uses thereof
28 Oct 19
Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.
Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
Filed: 25 Nov 18
Utility
Immune Modulation for the Treatment of Age-related Macular Degeneration
16 Oct 19
The invention provides methods for treating age-related macular degeneration by administering (i) peptide compositions, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and said peptide compositions.
Robert Nussenblatt, Baoying LIU, Lai Wei, Elazar RABBANI, James J. DONEGAN
Filed: 12 Jun 19
Utility
Pharmaceutical Compositions and Methods Targeting WNT Pathway Proteins
9 Oct 19
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213.
Joshua Rabbani, Xiaofeng Li, James J. Donegan
Filed: 28 Apr 19