42 patents
Utility
Compositions for Preparing Regulatory T-Cell Compositions for the Treatment of Autoimmune Disease
16 Nov 23
The invention provides cell culture compositions for regulatory T-cells that include particular synthetic peptides.
Robert NUSSENBLATT, Baoying LIU, Lai WEI, Elazar RABBANI, James J. DONEGAN
Filed: 26 Jul 23
Utility
Sphingosine Pathway Modulating Compounds For The Treatment Of Coronavirus Infection
25 May 23
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 11 Jan 23
Utility
Use of Organic Cationic Compounds to Accelerate Nucleic Acid Hybridization, Synthesis, and Amplification
5 Jan 23
The invention provides methods for accelerated synthesis of nucleic acids, and related compositions which involve the use of organic amines in the nucleic acid synthesis reaction mixture.
Elazar Rabbani, Jack Coleman
Filed: 15 Dec 21
Utility
Assays for Detecting Modified Compounds
3 Feb 22
Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified.
Elazar Rabbani, Jannis G. Stavrianopoulos, Joshua Rabbani, Praveen Pande
Filed: 14 Oct 21
Utility
Pharmaceutical Compositions and Methods Targeting WNT Pathway Proteins
27 Jan 22
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213.
Joshua Rabbani, Xiaofeng Li, James J. Donegan
Filed: 5 Oct 21
Utility
Immunomodulatory Pharmaceutical Compositions Including a Synthetic Peptide and Transforming Growth Factor Beta
27 Jan 22
The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and one or more immune tolerance enhancers.
Robert Nussenblatt, Baoying Liu, Lai Wei, Elazar Rabbani, James J. Donegan
Filed: 12 Oct 21
Utility
Fluorescence Quencher Polymer Conjugates and Uses Thereof
27 Jan 22
The invention provides chemical conjugates comprising a plurality of fluorescence quenching moieties conjugated to polymer and the use of such conjugates to quench the emission of fluorescence from emitters including macromolecular fluorescent emitters such as phycoerythrin.
Elazar Rabbani, Jack Coleman
Filed: 30 Jun 21
Utility
Comprehensive and Comparative Flow Cytometry-based Methods for Identifying the State of a Biological System
30 Sep 21
The invention provides comprehensive and comparative flow cytometry-based methods for characterizing the state of a biological system by determining cell phenotypes and associated gene expression profiles.
Elazar Rabbani, James J. Donegan, Andrew Stewart L'Huillier
Filed: 4 May 21
Utility
Hydroxycholesterol Immunoassay
30 Sep 21
Provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol.
Michael C. Mullenix, ROBERT ELLIOT ZIPKIN, JEFFREY KROLL ADAMS, WAYNE FORREST PATTON, JAMES J. DONEGAN
Filed: 14 Apr 21
Utility
Sphingosine Pathway Modulating Compounds for the Treatment of Coronavirus Infection
23 Sep 21
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
Utility
Sphingosine Pathway Modulating Compounds For The Treatment Of Coronavirus Infection
23 Sep 21
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
Utility
Glucocerebroside Treatment of Disease
26 Aug 21
The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects.
Yaron Ilan, Maya Margalit, Ari Zimran
Filed: 10 Feb 21
Utility
Affinity Tag Nucleic Acid and Protein Compositions and Processes for Using Same
15 Jul 21
The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides.
Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Wayne Patton, Juan Carcamo, Jack Coleman
Filed: 29 Mar 21
Utility
Sphingosine Kinase Type 1 Inhibitors and Uses Thereof
17 Jun 21
Provided are inhibitors of sphingosine kinase Type I that are useful in the treatment of neuropathic pain.
Sarah SPIEGEL, Robert Elliot ZIPKIN, Jeffrey Kroll ADAMS
Filed: 8 Feb 21
Utility
Sphingosine Pathway Modulating Compounds for the Treatment of Cancers
10 Jun 21
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani, James J. Sonegan
Filed: 19 Nov 20
Utility
Antibodies Specific for Sulfation Sites of WNT Pathway Proteins
3 Jun 21
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a.
Joshua Rabbani, James J. Donegan
Filed: 22 Dec 20
Utility
Affinity Tag Nucleic Acid and Protein Compositions and Processes for Using Same
3 Jun 21
The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides.
Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Wayne Patton, Juan Carcamo
Filed: 4 Jan 21
Utility
Fluorescent Dyes and Methods of Use Thereof
18 Mar 21
Zaiguo Li, Praveen Pande
Filed: 19 Nov 20
Utility
Monoazo Dyes with Cyclic Amine As Fluorescence Quenchers
18 Mar 21
The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles.
Zaiguo Li, Praveen Pande, Natarajan Raju
Filed: 2 Nov 20
Utility
Compositions for Preparing Regulatory T-Cell Compositions for the Treatment of Autoimmune Disease
11 Mar 21
The invention provides cell culture compositions for regulatory T-cells that include particular synthetic peptides.
Robert Nussenblatt, Baoying LIU, Lai WEI, Elazar RABBANI, James J. DONEGAN
Filed: 9 Sep 20