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AMGEN (AMGN)

Design
Infusion pump
27 Sep 22
Scott R. Gibson, Mehran Mojarrad, Paul Daniel Faucher
Filed: 24 Oct 19
Utility
Synthesis of Omecamtiv Mecarbil
22 Sep 22
Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.
Sebastien CAILLE, James MURRAY, Kyle QUASDORF, Hannah NGUYEN, Maria Victoria SILVA ELIPE, Ari Elizabeth ERICSON
Filed: 9 Mar 22
Utility
Method of antigen-binding protein production
20 Sep 22
The present disclosure relates to methods of re-oxidizing an antigen-binding protein.
Elaheh Binabaji, Chio Mui Chan, Hadley Krizner, Junfen Ma, Diana Woehle
Filed: 13 Dec 18
Utility
Antibody constructs for FLT3 and CD3
20 Sep 22
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell.
Tobias Raum, Claudia Blümel, Franziska Bott, Christoph Dahlhoff, Patrick Hoffmann, Elisabeth Nahrwold, Jochen Pendzialek
Filed: 1 Aug 16
Utility
KIF18A Inhibitors
15 Sep 22
Nuria A. TAMAYO, Abhisek BANERJEE, Jian Jeffrey CHEN, Matthew Paul BOURBEAU, Matthew Richard KALLER, Jonathan Dante LOW, Ana Elena MINATTI, Thomas T. NGUYEN, Nobuko NISHIMURA, Liping H. PETTUS, Mary Catherine WALTON, Qiufen May XUE, John Gordon ALLEN
Filed: 3 Aug 20
Utility
Pressure Relief Valve for Drug Delivery Device
15 Sep 22
A drug delivery device includes a housing releasably coupled with a patient, a pressure chamber disposed in the housing and including a vent, a container at least partially disposed in the pressure chamber for storing a drug connectable in fluid communication with a fluid conduit, an activation mechanism, and a relief mechanism.
Mehran Mojarrad, Ali Nekouzadeh, Scott R. Gibson, Sheldon Moberg, Paul Daniel Faucher
Filed: 16 Jul 20
Utility
INTERLEUKIN-2 Muteins for the Expansion of T-regulatory Cells
15 Sep 22
Provided herein are IL-2 muteins and IL-2 mutein Fc fusion molecules that preferentially expand and activate cells and are amenable to large scale production.
Darren L. BATES, Sue J. SOHN, Hannah Beth CATTERALL, Zhulun WANG
Filed: 13 Aug 20
Utility
Drug Delivery Device Having Removable Cap
15 Sep 22
A drug delivery device including a housing, a drug storage container, and a removable cap is provided.
Steve Sanchez, Michael John McColligan, Austin Davis, Yangkun Song, Anders Grove Sund, Gregory Thomas Nowak
Filed: 9 Mar 22
Utility
Activatable Injection Device for Drug Delivery
15 Sep 22
Injection devices for drug delivery are disclosed.
Christian Plambech, Bjarke Lykke Ludvig Svendsen
Filed: 25 Aug 20
Utility
Drug Delivery Device
15 Sep 22
A drug delivery device including a housing, a drug storage container, and a removable cap is provided.
Austin Davis, Lars Eilertsen, David Lavmand Muller, Rasmus Ohlenschlaeger, Gregory Thomas Nowak, Kasper Poder, Dylan Bourelle
Filed: 9 Mar 22
Utility
Drug Delivery Device, Subassembly for Drug Delivery Device, Syringe Holder, and Method of Assembly
15 Sep 22
A syringe holder for a drug delivery device is provided.
Lars Eilertsen, Troels Pedersen, Kasper Hjortkjaer Nielsen, Jacob Lykke Jensen, Peter Wemer Hansen
Filed: 9 Mar 22
Utility
Systems and Methods for Prediction of Protein Formulation Properties
15 Sep 22
In a method for predicting a property of potential protein formulations, a set of formulation descriptors is classified as belonging to a specific one of a plurality of predetermined groups that each correspond to a different value range for a protein formulation property.
Cindy Ren, Mohan B. Boggara, Nitin Rathore, Behnam Partopour
Filed: 25 Aug 20
Utility
Combination therapy including a KRAS
13 Sep 22
James Russell Lipford, Jude Robert Canon, Anne Y. Saiki, Karen Louise Rex
Filed: 18 Nov 19
Utility
Drug delivery device
13 Sep 22
A drug delivery device includes a blunt cannula and a reservoir.
Lawrence Ring, Dhairya Mehta, Stephanie Toy, Ferry Tamtoro, Alexander Stuart Cairns, Scott R. Gibson
Filed: 31 Jan 20
Utility
Processes of Making and Crystalline Forms of a MDM2 Inhibitor
8 Sep 22
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates.
Matthew BIO, Sebastien CAILLE, Brian COCHRAN, Yuanqing FANG, Brian M. FOX, Brian S. LUCAS, Lawrence R. MCGEE, Filisaty VOUNATSOS, Sean H. WIEDEMANN, Sarah WORTMAN
Filed: 13 Oct 21
Utility
Combination Therapy Including an MDM2 Inhibitor and One or More Additional Pharmaceutically Active Agents for the Treatment of Cancers
8 Sep 22
The present invention provides combination therapy that includes an MDM2 inhibitor and one or more additional pharmaceutically active agents, particularly for the treatment of cancers.
Sean Caenepeel, Jude Canon, Paul Hughes, Jonathan D. Oliner, Richard J. Rickles, Anne Y. Saiki
Filed: 9 Sep 21
Utility
KIF18A Inhibitors
8 Sep 22
Nuria A. TAMAYO, Abhisek BANERJEE, Matthew Paul BOURBEAU
Filed: 3 Aug 20
Utility
Manufacturing Process for Hollow Plunger Rod
8 Sep 22
A method of manufacturing a plunger of a drug delivery device includes forming a plunger body.
Emil Finkelstein, Jan Jensen
Filed: 7 Mar 22
Utility
ANTI-IL13 Antigen Binding Proteins
8 Sep 22
The present invention is related to antibodies directed to IL-13 and uses of such antibodies.
Agnieszka KIELCZEWSKA, Ian Nevin FOLTZ, Palaniswami RATHANASWAMI, Maria Sheena AMADOR, Bram ESTES, Igor D'ANGELO
Filed: 24 Jul 20
Utility
Bisamide Sarcomere Activating Compounds and Uses Thereof
8 Sep 22
Luke ASHCRAFT, Alessandro BOEZIO, John BUTLER, Aroop CHANDRA, Chihyuan CHUANG, Scott E. COLLIBEE, Mikkel DEBENEDETTO, Vincent DIMASSA, Russell GRACEFFA, Justin MALINOWSKI, David MOEBIUS, Bradley P. MORGAN, Joshua PAYETTE, Antonio ROMERO, David ST. JEAN, JR., Richard VARGAS, John YEOMAN, Hanmo ZHANG, Alan CHENG, Felix GONZALEZ LOPEZ DE TURISO, Michael Garrett JOHNSON
Filed: 15 Feb 22
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