1083 patents
Page 4 of 55
Utility
Synthesis of Sulfonamide Intermediates
9 Nov 23
Neil Fred LANGILLE, Jason S. TEDROW, Jonathan Vinh-Phu TRUONG, Robert Ronald MILBURN, Alessandro ARENA
Filed: 28 Apr 21
Utility
Methods of Treating Heart Failure with Cardiac Sarcomere Activators
9 Nov 23
Provided herein are methods of treating a subject with heart failure, comprising administering to the subject an initial dose of a cardiac sarcomere activator (CSA) for an initial time period, and subsequently administering to the subject a dose of the CSA based on the subject's plasma concentration of the CSA at the end of the initial time period.
Narimon HONARPOUR, Fady MALIK
Filed: 5 May 23
Utility
Drug Delivery System and Method of Use
9 Nov 23
A drug delivery system is disclosed that includes a drug delivery device having a reservoir and a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient.
Adam B. McCullough, Ferry Tamtoro, Huaying Yang, Mark Ka Lai Lee, Desheng Yin, Scott R. Gibson, Donald Busby, Peter V. Shultz, Keith P. Kogler, Jimmie L. Ward, Christopher R. Folk, Steven William Badelt
Filed: 6 Jul 23
Utility
Controlled Dispense Syringe
9 Nov 23
A syringe is described with a plunger assembly that is adapted to have a dispensing stroke sized to dispense a fluid therapeutic product from the syringe without dispensing any air or headspace.
Samin Akbari, Paul Daniel Faucher
Filed: 8 Feb 21
Utility
Cross-species-specific Binding Domain
9 Nov 23
The present invention relates to a polypeptide comprising a human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain as well as to a process for the production of the mentioned polypeptide.
Peter Kufer, Tobias Raum, Roman Kischel, Ralf Lutterbüse, Patrick Hoffmann, Matthias Klinger, Doris Rau, Susanne Mangold
Filed: 15 Dec 22
Utility
Methods and Systems for Determining a Minimum Number of Cell Line Clones Necessary to Produce a Product Having a Set of Target Product Attributes
9 Nov 23
Methods and systems for determining a minimum number of cell line clones necessary to produce a product having a set of target product attributes are disclosed.
Huong Thi Ngoc Le, Jasmine Tat, Ewelina Zasadzinska
Filed: 9 Sep 21
Design
Handheld drug delivery device
7 Nov 23
Emil Finkelstein, Kasper Friis, Lars Eilertsen
Filed: 17 May 23
Utility
Drug delivery device having a needle guard mechanism with a turnable threshold of resistance to needle guard movement
7 Nov 23
A drug delivery device includes a casing and a storage container with a dose delivery member, at least a portion of which extends through an opening in the casing.
Scott R. Gibson, Sheldon Moberg
Filed: 26 Feb 16
Utility
Deuterated compounds as immunomodulators
7 Nov 23
Pingchen Fan, Rebecca M. Lui, Venkat Reddy Mali, Rajinder Singh, Yibin Zeng, Penglie Zhang
Filed: 9 Oct 20
Utility
Substituted pyrimidinones as agonists of the APJ receptor
7 Nov 23
Vatee Pattaropong, Philip Dean Ramsden
Filed: 30 Apr 19
Utility
Cyclopropyl dihydroquinoline sulfonamide compounds
7 Nov 23
Benjamin C Milgram, Isaac E Marx, John Stellwagen, Wei Zhao, Alan H. Cherney
Filed: 10 Jun 21
Utility
Apelin polypeptides
7 Nov 23
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide.
Jerry Ryan Holder, Gayathri Swaminath, Michael J. Frohn, Brian Alan Lanman, Anthony B. Reed, Leslie P. Miranda, John Gordon Allen, Alexander J. Pickrell, Aaron C. Siegmund, Lewis D. Pennington, Bryant Yang
Filed: 28 Jan 21
Utility
Methods of Processing a Sample for Peptide Mapping Analysis
2 Nov 23
Provided herein are methods of processing a polypeptide or protein for analysis, e.g., peptide mapping analysis by mass spectrometry.
Gang XIAO, Pavel BONDARENKO, Liuqing SHI, Thomas M. DILLON, Da REN, Margaret Speed RICCI, Weidong CUI, John Joseph HARRAHY, Jake PAWLOWSKI, Andrew DYKSTRA, Dylan RIGGS
Filed: 17 Sep 21
Utility
Flow Restrictor for Drug Delivery Device
2 Nov 23
A drug delivery device includes a housing, a container disposed in the housing, a drive mechanism, a needle assembly, a fluid flow path, and a vortex flow adapter.
Ali Nekouzadeh, Mehran Mojarrad, Joshua Tamsky, Paul Daniel Faucher, Scott R. Gibson, Kimberly Sepulveda, Sheldon B. Moberg
Filed: 17 Nov 20
Utility
Selecting Resins for Use in Chromatography Purification Processes
2 Nov 23
A method of selecting raw materials for use in a column chromatography purification process in which, for each of one or more candidate resins, a respective set of resin attribute values is received, including at least one analytical measurement of the candidate resin.
Hector Nogueras, Myra Coufal, Deborah Soto-Ortega
Filed: 16 Jul 21
Utility
Pharmaceutical Formulation
2 Nov 23
The disclosure provides a formulation comprising, e.g., a bispecific antibody construct, a buffer, a saccharide, a surfactant, and methionine.
Bharadwaj Jagannathan
Filed: 23 Aug 21
Utility
Methods of Measuring Carfilzomib
2 Nov 23
Provided herein are improved methods for measuring the concentration of carfilzomib in a sample.
Emma Harper, Dawn Elyse Cohen
Filed: 18 Jun 21
Utility
Methods and apparati for nondestructive detection of undissolved particles in a fluid
31 Oct 23
An apparatus for nondestructive detection of transparent or reflective objects in a vessel includes an imager configured to acquire data that represent light reflected from spatial locations in the vessel as a function of time, a memory operably coupled to the imager and configured to store the data, and a processor operably coupled to the memory and configured to detect the objects based on the data by (i) identifying a respective maximum amount of reflected light, over time, for each location in the spatial locations based on the data representing light reflected from the spatial locations as a function of time, and (ii) determining a presence or absence of the objects in the vessel based on the number of spatial locations whose respective maximum amount of reflected light, over time, exceeds a predetermined value.
Graham F. Milne, Erwin Freund, Ryan L. Smith
Filed: 12 Oct 22
Utility
CXCR6 Sulfonamide Compounds
26 Oct 23
Hiufung CHU, Pingchen FAN, Yandong LI, Viengkham MALATHONG, Jay POWERS, Hiroko TANAKA, Yibin ZENG, Penglie ZHANG
Filed: 20 Mar 23
Utility
Immunomodulator compounds
24 Oct 23
Christopher Lange, Viengkham Malathong, Darren J. McMurtrie, Sreenivas Punna, Rajinder Singh, Ju Yang, Penglie Zhang
Filed: 13 Jun 22