1083 patents
Page 6 of 55
Utility
Crystalline antibody formulations
3 Oct 23
Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.
Twinkle R. Christian, Christi L. Clogston, Timothy David Osslund
Filed: 24 Feb 20
Utility
Processes of Making and Crystalline Forms of a MDM2 Inhibitor
28 Sep 23
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates.
Matthew BIO, Sebastien CAILLE, Brian COCHRAN, Yuanqing FANG, Brian M. FOX, Brian S. LUCAS, Lawrence R. MCGEE, Filisaty VOUNATSOS, Sean H. WIEDEMANN, Sarah WORTMAN
Filed: 8 May 23
Utility
Swallowable Drug Delivery Devices
28 Sep 23
A swallowable drug delivery device includes a capsule and a tissue attachment member.
Mehran Mojarrad, Scott R. Gibson, Scott Castanon, Robert Eisele, Dylann Ceriani
Filed: 2 Sep 21
Utility
Drug delivery mechanism
26 Sep 23
A flexible plunger rod, drug delivery mechanism, drug delivery device, and methods are described that utilize the flexible plunger rod perform drug delivery operations.
Sudeshna Dutta Ray, Scott R. Gibson, Daniel Eduardo Groszmann, Mehran Mojarrad, Robert Allen Dees, Jonathan Dean Johnson, Antonio S. Murcia
Filed: 17 Jan 19
Utility
KRAS G12C inhibitors and methods of using the same
26 Sep 23
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same.
John Gordon Allen, Jennifer Rebecca Allen, Ana Elena Minatti, Qiufen Xue, Ryan Paul Wurz, Christopher M. Tegley, Alexander J. Pickrell, Thomas T. Nguyen, Vu Van Ma, Patricia Lopez, Longbin Liu, David John Kopecky, Michael J. Frohn, Ning Chen, Jian Jeffrey Chen, Aaron C. Siegmund, Albert Amegadzie, Nuria A. Tamayo, Shon Booker, Clifford Goodman, Mary Walton, Nobuko Nishimura, Youngsook Shin, Jonathan D. Low, Victor J. Cee, Anthony B. Reed, Hui-Ling Wang, Brian Alan Lanman
Filed: 30 Jun 21
Utility
Robotic system for performing pattern recognition-based inspection of pharmaceutical containers
26 Sep 23
A robotic inspection platform comprises a robotic arm, an imager, and a controller.
Dmitry Fradkin, Thomas C. Pearson, Neelima Chavali, Erwin Freund
Filed: 12 Jun 19
Utility
Easy Open Apparatus for Medicament Storage Carton
21 Sep 23
A carton for medicament storage includes a bottom box and a lid.
Trevor Raymond Lowe, Joshua Merilos, Scott J. Gerondale, Lrr Thompson, Harrison North, Jeffrey Burmeister, Alexander Rentschler, Brian McGonigle
Filed: 2 Sep 21
Utility
Stabilized Receptor Polypeptides and Uses Thereof
21 Sep 23
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11.
Jeonghoon SUN, Lei-Ting Tony TAM, Mark Leo MICHAELS, Thomas Charles BOONE, Rohini R. DESHPANDE, Yue-Sheng LI, Huiquan HAN
Filed: 7 Jun 23
Utility
Heterocyclic Compounds As Triggering Receptor Expressed on Myeloid Cells 2 Agonists and Methods of Use
21 Sep 23
Lara C. CZABANIUK, Timothy Hopper, Jonathan B. Houze, Jane Panteleev, Gwenaella Rescourio, Vincent Santora, Haoxuan Wang, Ryan D. White, Alice R. Wong, Yongwei Wu, Maxence Bos, John Mancuso, Ivan Franzoni
Filed: 30 Nov 22
Utility
Heterocyclic Compounds As Triggering Receptor Expressed on Myeloid Cells 2 Agonists and Methods of Use
21 Sep 23
Lara C. CZABANIUK, Timothy HOPPER, Jonathan B. HOUZE, Jane PANTELEEV, Gwenaella RESCOURIO, Vincent SANTORA, Haoxuan WANG, Ryan D. WHITE, Alice R. WONG, Yongwei WU, Maxence BOS, John MANCUSO, Ivan FRANZONI
Filed: 30 Nov 22
Utility
Flow adapter for drug delivery device
19 Sep 23
A drug delivery device includes a housing defining a shell, a container, a drive mechanism, a needle assembly having first and second ends, a fluid flow connection, and a flow adapter, each of which is at least partially disposed within the housing.
Carl Conrath, Ali Nekouzadeh, Basel Hasan Taha
Filed: 26 Sep 18
Utility
Indane-amines as PD-L1 antagonists
19 Sep 23
Christopher Lange, Sreenivas Punna, Rajinder Singh, Ju Yang, Penglie Zhang
Filed: 30 Aug 21
Utility
Diazole lactams
19 Sep 23
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity.
Xi Chen, Pingchen Fan, Yandong Li, Jay P. Powers, Viengkham Malathong, Sreenivas Punna, Hiroko Tanaka, Penglie Zhang, Dean Dragoli
Filed: 8 Jul 20
Utility
Injector and method of assembly
19 Sep 23
An injector may include a container having a wall with an interior surface defining a closed sterile reservoir filled with a drug product.
Scott R. Gibson
Filed: 16 Oct 20
Utility
Cell Culture Media and Methods of Making and Using the Same
14 Sep 23
Presented herein are methods for preparing and treating mammalian cell culture media through the addition of low levels of poloxamer and nanofiltration.
Nicholas MARCHAND, Glen BOLTON, Sara Ann GALL, Jian WU
Filed: 27 Jul 21
Utility
Formulations of apremilast
12 Sep 23
Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice.
Nathan Bennette, William Brett Caldwell, Christi Hostetler, Kazden Ingram, Dory King, Kyle Kyburz, Alison Viles
Filed: 31 Aug 22
Utility
Drug delivery device with sterile fluid flowpath and related method of assembly
12 Sep 23
Drug delivery devices and related methods of assembly are disclosed.
Yasaman Damestani, Lawrence S. Ring
Filed: 17 Jan 18
Utility
Processes for preparing a MDM2 inhibitor
12 Sep 23
The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.
Sebastien Caille, Michael Corbett, Austin Smith
Filed: 30 Aug 19
Utility
Synthesis of omecamtiv mecarbil
12 Sep 23
Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
Sebastien Caille, Kyle Quasdorf, Philipp C. Roosen, Xianqing Shi, Andrew Cosbie, Fang Wang, Zufan Wu, Archana Neergunda, Bin Peter Quan, Lianxiu Guan
Filed: 19 May 21
Utility
Bispecific-Fc molecules
12 Sep 23
Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions.
Luis G. Borges, Patrick A. Baeuerle, Wei Yan, Mark L. Michaels
Filed: 1 Feb 18