684 patents
Page 10 of 35
Utility
Heterocyclic Compounds As Triggering Receptor Expressed on Myeloid Cells 2 Agonists and Methods of Use
5 Jan 23
Lara C. CZABANIUK, Timothy HOPPER, Jonathan B. HOUZE, Jane PANTELEEV, Gwenaella RESCOURIO, Vincent SANTORA, Haoxuan WANG, Ryan D. WHITE, Alice R. WONG, Yongwei WU, Maxence BOS, John MANCUSO, Ivan FRANZONI
Filed: 4 May 21
Utility
Dosage Regimen for Anti-egfrviii Agents
29 Dec 22
The invention provides a method for the treatment of EGFRvIII-positive cancer or glioblastoma, comprising administering to a subject in need thereof an initial dose of between about 15 μg/day to about 6000 μg/day of an anti-EGFRvIII agent.
Johannes Kast, Sabine Karin Stienen, Vijay Upreti, Marc Anthony Yago
Filed: 5 Nov 20
Utility
Syringes, Assemblies, and Methods of Manufacture
29 Dec 22
Syringes, assemblies for use in a filling process, and related methods of manufacture are disclosed.
Rasmus Ohlenschlaeger, Jerome Olivas
Filed: 22 Jun 22
Utility
Hematopoietic Precursor Cell Production
29 Dec 22
This invention provides improved methods for generation of hematopoietic precursor cells from a pluripotent stem cell and hematopoietic precursor cells generated thereof.
Stuart CHAMBERS, Jingli Hu ZHANG, Qingwen CHENG, Guanyi HUANG
Filed: 13 Nov 20
Utility
Offline Troubleshooting and Development for Automated Visual Inspection Stations
29 Dec 22
In a method for replicating performance of an automated visual inspection (AVI) station, a mimic AVI station that performs one or more AVI functions of the AVI station is constructed.
Graham F. Milne, Thomas C. Pearson, Joseph Peter Bernacki
Filed: 10 Nov 20
Utility
Methods of Protein Clips Recovery
22 Dec 22
The disclosed methods are directed to detecting polypeptide fragments (“clips”) of parental polypeptides.
Da REN, Izydor APOSTOL, Alexander Julian VEACH
Filed: 7 Jun 22
Utility
Drug Product Container and Drug Delivery System
22 Dec 22
A drug delivery device includes a drug product container, a pressurized vessel, and an urging member.
Scott R. Gibson, Paul D. Faucher, Mehran Mojarrad
Filed: 14 Oct 20
Utility
Drug Delivery Device Having Shock Absorber
22 Dec 22
A drug delivery device is provided, including a housing, a drug storage container, a plunger, a plunger biasing member, a releaser, and a shock absorber.
Kasper Poder, David Lavmand Muller, Peter Werner Hansen, Lars Eilertsen
Filed: 16 Jun 22
Utility
ENGINEERED NRG-1 VARIANTS WITH IMPROVED SELECTIVITY TOWARD ErbB4 BUT NOT AGAINST ErbB3
22 Dec 22
The present invention relates to engineered neuregulin-1 variants that selectively activate ErbB4 receptors but do not activate ErbB3 receptors.
Darren L. BATES, Zhi LIU, TaeWeon LEE, Mark L. MICHAELS, Zhulun WANG
Filed: 9 Jun 22
Utility
Production of Glycoproteins Using Manganese
22 Dec 22
Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.
Christopher Kenyon Crowell, Gustavo Enrique Grampp
Filed: 31 Aug 22
Utility
Multitargeting Antigen-binding Molecules for Use In Proliferative Diseases
22 Dec 22
The present invention provides bispecific antigen-binding molecules characterized by comprising a first and a second domain, each binding to any of CS1, BCMA, CD20, CD22, FLT3, CD123, CLL1, MSLN, CDH3 or EpCAM, a third domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a fourth domain, which is a Fc modality.
Jonas Anlahr, Tara Arvedson, Julie Bailis, Matthew Chun, Igor D'Angelo, Christopher Dahlhoff, Stephanie Everts, Mattias Friedrich, Lars Gaedtke, Patrick Hoffmann, Rebecca Goldstein, Jonas Karl-Josef Honer, Roman Kischel, Matthias Klinger, Peter Kufer, Markus Muenz
Filed: 6 Nov 20
Utility
ANTI-CCR8 Antibodies and Uses Thereof
22 Dec 22
The present invention provides anti-CCR8 antibodies and antigen-binding fragments thereof, and methods of making and using said anti-CCR8 antibodies and antigen-binding fragments thereof.
NATHAN WILLIAM PIERCE, AGNIESZKA KIELCZEWSKA, WENTAO CHEN, OLIVIER NOLAN-STEVAUX, DARREN L. BATES, LISA WINKEL, CHRISTOPH DAHLHOFF, TOBIAS RAUM, CLAUDIA BLUEMEL, JONAS KARL-JOSEF HONER
Filed: 2 Jun 22
Utility
Method of Treating or Ameliorating Cushing's Syndrome Using Binding Proteins for Gastric Inhibitory Peptide Receptor (Gipr)
22 Dec 22
Methods of treating diseases and disorders characterized by elevated levels of cortisol using an antigen binding protein specific for the GIPR polypeptide are provided.
David John LLOYD, Elizabeth Ann KILLION, Glenn N. SIVITS, JR.
Filed: 9 Nov 20
Utility
Kras G12C Inhibitors and Methods of Using the Same
15 Dec 22
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same.
John Gordon ALLEN, Jennifer Rebecca ALLEN, Ana Elena MINATTI, Qiufen XUE, Ryan Paul WURZ, Christopher M. TEGLEY, Alexander J. PICKRELL, Thomas T. NGUYEN, Vu Van MA, Patricia LOPEZ, Longbin LIU, David John KOPECKY, Michael J. FROHN, Ning CHEN, Jian Jeffrey CHEN, Aaron C. SIEGMUND, Albert AMEGADZIE, Nuria A. TAMAYO, Shon BOOKER, Clifford GOODMAN, Mary WALTON, Nobuko NISHIMURA, Youngsook SHIN, Jonathan D. LOW, Victor J. CEE, Anthony B. REED, Hui-Ling WANG, Brian Alan LANMAN
Filed: 30 Jun 21
Utility
Drug Delivery System and Method of Use
15 Dec 22
A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, a flow rate sensor, and a flow controller.
Shawn P. Malloy
Filed: 29 Oct 20
Utility
Method for Reduced Aggregate Formation in Downstream Processing of Bispecific Antigen-Binding Molecules
15 Dec 22
The present disclosure provides a downstream manufacturing method for the production of bispecific antigen-binding molecule products, which comprise at least two different binding domains.
Yan Wang, Nicholas Marchand, Robert Perry Brake, Maria Perry, Ashish Sharma, Eugene Sun
Filed: 13 Nov 20
Utility
Targeted Application of Deep Learning to Automated Visual Inspection Equipment
15 Dec 22
In a method for enhancing accuracy and efficiency in automated visual inspection of vessels, a vessel containing a sample is oriented such that a line scan camera has a profile view of an edge of a stopper of the vessel.
Neelima Chavali, Thomas C. Pearson, Manuel A. Soto, Jorge Delgado Torres, Roberto C. Alvarado Rentas, Javier O. Tapia, Sandra Rodriguez-Toledo, Eric R. Flores-Acosta, Osvaldo Perez, Brenda A. Torres
Filed: 6 Nov 20
Utility
Methods for Treating Leukemia
8 Dec 22
The present invention relates to treatment methods for leukemia using bispecific antibody constructs that specifically bind to human CD33 and human CD3.
Suresh AGARWAL, Sophia KHALDOYANIDI, Dirk NAGORSEN, Vijay UPRETI
Filed: 3 Nov 20
Utility
Systems and Methods for Drug Delivery
8 Dec 22
A drug delivery system includes a packaging housing a first component including at least one of a drug product, a diluent, a saline solution, or an IV stabilizing solution (“IVSS”) and a second component comprising at least one of the drug product, the diluent, the saline solution, and the IVSS, the first component being different than the second component.
Scott R. Gibson, Xiaotong Li, Nicholas J. Clark, Carsten Bech, Daniel Rojecki, Joshua Jay Dudman, Jakob Pedersen, Jennifer L. Sawicky, Laura Watson
Filed: 14 Oct 20
Utility
Drug Delivery Device
8 Dec 22
A drug delivery device is provided that includes a housing, a fluid displacement assembly at least partially supported by and/or surrounded by the housing, and a drive component at least partially supported by and/or surrounded by the housing.
Scott R. Gibson, Mehran Mojarrad, Paul D. Faucher
Filed: 23 Oct 20