684 patents
Page 2 of 35
Utility
Process for Racemizing and Isolating Atropisomers of 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE
7 Dec 23
Matthew G. BEAVER, Michael T. CORBETT, Yuanqing FANG, David D. FORD, Andrew T. PARSONS, Gabrielle ST-PIERRE, Reem TELMESANI
Filed: 6 Oct 21
Utility
FREE BASE CRYSTALLINE FORM OF A COMPLEMENT COMPONENT C5a RECEPTOR
30 Nov 23
Rajinder SINGH, Kwok YAU, Yibin ZENG, Penglie ZHANG, Rebecca M. LUI, Antoni KRASINSKI
Filed: 24 Apr 23
Utility
INTERLEUKIN-21 Mutein/ ANTI-PD-1 Antibody Conjugates
30 Nov 23
Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease.
Khaled M.K.Z. ALI, Neeraj Jagdish AGRAWAL, Gunasekaran KANNAN, Ian FOLTZ, Zhulun WANG, Darren BATES, Marissa MOCK, Shunsuke TAKENAKA
Filed: 1 Dec 22
Utility
Drug Delivery Device Assembly and Accessory for Drug Delivery Device
30 Nov 23
A drug delivery device assembly is provided, including an injector housing, a needle assembly, a drive assembly, and a needle shield indicator accessory.
Jakob Halkjaer Pedersen, Joshua Jay Dudman
Filed: 1 Nov 21
Utility
Drug Delivery Device Assembly and Accessory for Drug Delivery Device
30 Nov 23
A drug delivery device assembly is provided, including an injector housing, a needle assembly, a drive assembly, and a dose feedback accessory.
Carsten Bech, Jakob Halkjaer Pedersen, Joshua Jay Dudman, Adrianus Gerardus Verschuren, Chiushun Dan
Filed: 1 Nov 21
Utility
Drug Delivery Device Assembly and Accessory for Drug Delivery Device
30 Nov 23
A drug delivery device assembly is provided, including an injector housing, a needle assembly, a drive assembly, and an alignment accessory.
Jakob Halkjaer Pedersen, Joshua Jay Dudman, Chiushun Dan, Kasper Friis, Carsten Bech, Adrianus Gerardus Verschuren, Michael John McColligan, Filip Saarman
Filed: 1 Nov 21
Utility
Rational Selection of Building Blocks for the Assembly of Multispecific Antibodies
23 Nov 23
The ability to generate a single antibody-based construct that can recognize multiple targets simultaneously, is paramount to advance many therapeutics candidates to clinic.
Danyang GONG, Fernando GARCES, Zhulun WANG
Filed: 5 Oct 21
Utility
Drug Delivery Device with Sterile Fluid Flowpath and Related Method of Assembly
23 Nov 23
Drug delivery devices and related methods of assembly are disclosed.
Yasaman Damestani, Lawrence S. Ring
Filed: 26 Jul 23
Utility
Processes for Preparing a MDM2 Inhibitor
23 Nov 23
The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.
Sebastien Caille, Michael Corbett, Austin Smith
Filed: 1 Aug 23
Utility
Synthesis of Omecamtiv Mecarbil
23 Nov 23
Sebastien CAILLE, Kyle QUASDORF, Philipp C. ROOSEN, Xianqing SHI, Andrew COSBIE, Fang WANG, Zufan WU, Archana NEERGUNDA, Bin Peter QUAN, Lianxiu GUAN
Filed: 26 Jul 23
Utility
Diol Desymmetrization by Nucleophilic Aromatic Substitution
16 Nov 23
MATTHEW G. BEAVER, JOSEPH MICHAEL DENNIS, PETER DORNAN, STEVEN MENNEN, JASON S. TEDROW, NEIL F. LANGILLE, CAROLYN MICHELLE COHEN, ANDREAS RENE ROTHELI
Filed: 1 Sep 21
Utility
Methods of Detecting Isoaspartic Acid
16 Nov 23
Disclosed herein are methods of processing a protein and detecting isoaspartic acid (isoAsp) in a protein.
John On-Ting HUI, Iain David Grant CAMPUZANO
Filed: 30 Sep 21
Utility
Machine Learning Techniques for Predicting Thermostability
16 Nov 23
Techniques for computationally screening a set of single-chain variable fragments (scFvs).
Ameya Harmalkar, Kathy Yufeng Wei
Filed: 9 May 23
Utility
Methods of Treating Heart Failure with Cardiac Sarcomere Activators
9 Nov 23
Provided herein are methods of treating a subject with heart failure, comprising administering to the subject an initial dose of a cardiac sarcomere activator (CSA) for an initial time period, and subsequently administering to the subject a dose of the CSA based on the subject's plasma concentration of the CSA at the end of the initial time period.
Narimon HONARPOUR, Fady MALIK
Filed: 5 May 23
Utility
Synthesis of Sulfonamide Intermediates
9 Nov 23
Neil Fred LANGILLE, Jason S. TEDROW, Jonathan Vinh-Phu TRUONG, Robert Ronald MILBURN, Alessandro ARENA
Filed: 28 Apr 21
Utility
Drug Delivery System and Method of Use
9 Nov 23
A drug delivery system is disclosed that includes a drug delivery device having a reservoir and a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient.
Adam B. McCullough, Ferry Tamtoro, Huaying Yang, Mark Ka Lai Lee, Desheng Yin, Scott R. Gibson, Donald Busby, Peter V. Shultz, Keith P. Kogler, Jimmie L. Ward, Christopher R. Folk, Steven William Badelt
Filed: 6 Jul 23
Utility
Controlled Dispense Syringe
9 Nov 23
A syringe is described with a plunger assembly that is adapted to have a dispensing stroke sized to dispense a fluid therapeutic product from the syringe without dispensing any air or headspace.
Samin Akbari, Paul Daniel Faucher
Filed: 8 Feb 21
Utility
Cross-species-specific Binding Domain
9 Nov 23
The present invention relates to a polypeptide comprising a human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain as well as to a process for the production of the mentioned polypeptide.
Peter Kufer, Tobias Raum, Roman Kischel, Ralf Lutterbüse, Patrick Hoffmann, Matthias Klinger, Doris Rau, Susanne Mangold
Filed: 15 Dec 22
Utility
Methods and Systems for Determining a Minimum Number of Cell Line Clones Necessary to Produce a Product Having a Set of Target Product Attributes
9 Nov 23
Methods and systems for determining a minimum number of cell line clones necessary to produce a product having a set of target product attributes are disclosed.
Huong Thi Ngoc Le, Jasmine Tat, Ewelina Zasadzinska
Filed: 9 Sep 21
Utility
Methods of Processing a Sample for Peptide Mapping Analysis
2 Nov 23
Provided herein are methods of processing a polypeptide or protein for analysis, e.g., peptide mapping analysis by mass spectrometry.
Gang XIAO, Pavel BONDARENKO, Liuqing SHI, Thomas M. DILLON, Da REN, Margaret Speed RICCI, Weidong CUI, John Joseph HARRAHY, Jake PAWLOWSKI, Andrew DYKSTRA, Dylan RIGGS
Filed: 17 Sep 21