684 patents
Page 9 of 35
Utility
Direct Selection of Cells Expressing High Levels of Heteromeric Proteins Using Glutamine Synthetase Intragenic Complementation Vectors
16 Feb 23
This invention relates to the general field of recombinant expression of polypeptides in animal cell culture.
Trent P. MUNRO, Neeraj Jagdish AGRAWAL, Kristine M. DARIS
Filed: 26 May 22
Utility
Novel Multispecific Antibody Format
16 Feb 23
The present invention relates to novel multispecific antigen binding proteins that are capable of binding to multiple targets.
Fernando GARCES, Zhulun WANG
Filed: 18 Nov 20
Utility
Compounds That Inhibit MCL-1 Protein
16 Feb 23
Sean P BROWN, David Karl BEDKE, Michael R. DEGRAFFENREID, Jiasheng FU, Zhinghong LI, Felix GONZALEZ LOPEZ DE TURISO, Ana GONZALEZ BUENROSTRO, Michael W. GRIBBLE JR., Michael G. JOHNSON, Todd J. KOHN, Kexue LI, Yunxiao LI, Mike Elias LIZARZABURU, Yosup REW, Joshua TAYGERLY, Yingcai WANG, Xuelei YAN, Ming YU, Jiang ZHU, Manuel ZANCANELLA, Xian Yun JIAO, Liusheng ZHU, Xianghong WANG, Julio C. MEDINA, Jason A. DUQUETTE, Jonathan B. HOUZE, Marc VIMOLRATANA, Mario G. CARDOZO, Alan C. CHENG
Filed: 14 Oct 21
Utility
Stable Compositions of Pegylated Carfilzomib Compounds
16 Feb 23
The present invention provides stable pharmaceutical compositions of pegylated carfilzomib compounds, methods for preparing the compositions, and uses of the compositions for treating cancer, including hematologic malignancies such as multiple myeloma.
Alona TERAN, William CALLAHAN, Qahera MUNAIM, Rahul KAUSHIK
Filed: 23 Dec 21
Utility
CROSS-SPECIES-SPECIFIC PSMAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY
9 Feb 23
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA).
Peter KUFER, Tobias RAUM, Roman KISCHEL, Ralf Lutterbüse, Patrick HOFFMANN, Doris RAU, Susanne MANGOLD, Matthias KLINGER, Evelyne SCHALLER, Susanne HAUSMANN, Petra FLUHR, Carola STEIGER
Filed: 2 Apr 21
Utility
Bispecific Antibody Constructs for CDH3 and CD3
9 Feb 23
The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell.
Bertram Weiss, Ann-Lena Frisk, Ruprecht Zierz, Peter Kufer, Tobias Raum, Doris Rau, Jonas Anlahr, Ralf Lutterbüse, Lisa Nahrwold, Christoph Dahlhoff, Claudia Blümel, Patrick Hoffmann
Filed: 3 May 21
Utility
INTERLEUKIN-2 In Combination with TNF Receptor Family Members for the Expansion of T-regulatory Cells
9 Feb 23
Provided herein are combinations of an IL-2 molecule or mutein and a TNFR agonist, and complexes comprising IL-2/TNFR agonist molecules, such as Fc-bound IL-2/TNFR agonist molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production.
Ashutosh CHAUDHRY, Wenjun OUYANG
Filed: 17 Dec 20
Utility
Drug Delivery Device with Container Access System and Related Method of Assembly
9 Feb 23
Drug delivery devices and related methods of assembly are disclosed.
Sheldon Moberg, Matthew Wayne Janke, Wael Mismar, Alexis Dechelette
Filed: 6 Oct 22
Utility
Methods and Apparati for Nondestructive Detection of Undissolved Particles In a Fluid
9 Feb 23
An apparatus for nondestructive detection of transparent or reflective objects in a vessel includes an imager configured to acquire data that represent light reflected from spatial locations in the vessel as a function of time, a memory operably coupled to the imager and configured to store the data, and a processor operably coupled to the memory and configured to detect the objects based on the data by (i) identifying a respective maximum amount of reflected light, over time, for each location in the spatial locations based on the data representing light reflected from the spatial locations as a function of time, and (ii) determining a presence or absence of the objects in the vessel based on the number of spatial locations whose respective maximum amount of reflected light, over time, exceeds a predetermined value.
Graham F. Milne, Erwin Freund, Ryan L. Smith
Filed: 12 Oct 22
Utility
Anti-bcma Heavy Chain-only Antibodies
9 Feb 23
Anti-BCMA heavy chain-only antibodies(HCAb) and disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B-cell disorders characterized by the expression of BCMA.
Shelley Force Aldred, Nathan Trinklein, Katherine E. Harris, Kevin Dang, Wim van Schooten
Filed: 29 Jun 22
Utility
In Vivo Reversibility of High Molecular Weight Species
2 Feb 23
Provided herein are in vitro methods of assaying an in vivo level of high molecular weight (HMW) species of a therapeutic protein.
Dong XIANG, Qingchun ZHANG, Marisa JOUBERT, Trent MUNRO, Ronandro DE GUZMAN
Filed: 4 Mar 20
Utility
Vegfr-fc Fusion Protein Formulations
26 Jan 23
VEGFR-Fc fusion protein formulations and methods of making using such formulations are provided herein.
Yael WEXLER-COHEN, Robert Matthew FESINMEYER, Monica Michelle GOSS, Sekhar KANAPURAM, Rahul Rajan KAUSHIK, Sai Chakradhar PADALA
Filed: 14 Sep 22
Utility
Dosing Regimen of Kras G12C Inhibitor
26 Jan 23
Provided herein are methods of administering a KRAS G12C inhibitor to a cancer subject.
Haby HENARY, James Russell LIPFORD, Victor J. CEE
Filed: 15 Dec 20
Utility
Adaptive Electrode Arrangement and Method for Implementation In a Cell Incubator System and Applications Thereof
26 Jan 23
A well for electrically stimulating at least one cell.
Chuck Z. Li, Brandon Zachary Sarich, Phillip Ng
Filed: 30 Sep 22
Utility
Container Visual Inspection Assembly and Method
26 Jan 23
Assemblies (10), devices, and methods are described herein that allow an examiner to inspect a container (12) of liquid product (14) through a bottom wall (18) of the container using a line-of-sight diversion member (28, e.g. beam splitter, mirror or prism).
Graham F. Milne, Dmitry Fradkin
Filed: 17 Dec 20
Utility
Capture Purification Processes for Proteins Expressed in a Non-Mammalian System
19 Jan 23
Methods of purifying proteins expressed in non-mammalian expression systems in a non-native soluble form directly from cell lysate are disclosed.
Joseph Edward SHULTZ, Roger HART
Filed: 27 Jul 22
Utility
C-terminal Antibody Variants
19 Jan 23
The invention generally relates to anti-sclerostin antibodies having C-terminal modifications, and compositions comprising such antibodies.
Zhe Huang, Jennitte LeAnn Stevens, Greg Flynn, Szilan Fodor, Mark Daris
Filed: 23 Sep 22
Utility
Methods for Treating or Preventing Migraine Headache
19 Jan 23
The present invention relates to methods of migraine prophylaxis using anti-CGRP receptor antibodies or binding fragments.
Hong SUN, Eduardo DUNAYEVICH, Robert A. LENZ, Gabriel VARGAS
Filed: 2 Sep 22
Utility
Formulations Of Apremilast
5 Jan 23
Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice.
Nathan Bennette, William Brett Caldwell, Christi Hostetler, Kazden Ingram, Dory King, Kyle Kyburz, Alison Viles
Filed: 31 Aug 22
Utility
Lockout Mechanism for Drug Delivery Device
5 Jan 23
A drug delivery device includes a housing, a container at least partially disposed within the housing and configured to contain a medicament, an injection mechanism at least partially disposed within the housing and configured to exert a force to urge the medicament from the container, a drug delivery component at least partially disposed within the housing, and at least one pin positioned adjacent to the housing and preventing activation of the activation mechanism until the at least one pin reaches a desired temperature.
Andrew Dunn
Filed: 23 Nov 20