363 patents
Utility
Sheet lighting for particle detection in drug product containers
16 Jan 24
In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color.
Thomas Clark Pearson, Graham F. Milne, Dmitry Fradkin, Erwin Freund
Filed: 27 Dec 22
Utility
Indanes as PD-L1 inhibitors
16 Jan 24
Viengkham Malathong, Venkat Reddy Mali, Darren J. McMurtrie, Sreenivas Punna, Howard S. Roth, Rajinder Singh, Ju Yang, Penglie Zhang
Filed: 9 Jul 20
Utility
Treatment of ovarian cancer in patients with ascites using a specific binding agent of human angiopoietin-2 in combination with a taxane
16 Jan 24
Methods and compositions for treating ovarian cancer in a human patient with ascites by administering a therapeutically effective amount of an Ang2 inhibitor in combination with a taxane.
Bruce Allen Bach, Florian Vogl
Filed: 3 Nov 20
Utility
Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement
16 Jan 24
A device and method for drug delivery includes a casing for housing a drug storage container, the container including a dose delivery member, at least a portion of the dose delivery member extending through an opening in the casing; a guard movable relative to the casing between extended and retracted positions; an interference arrangement for providing selected threshold of resistance to movement of the guard from the extended position to the retracted position during insertion of the dose delivery member into body tissue at an injection site, the arrangement having a first member and a second member, the first and second members engaging one another to retain the guard in the extended position, one of the first and second members moving if the selected threshold of resistance is exceeded to allow the members to slide past one another to allow the guard to move into the retracted position.
Scott R. Gibson, Sheldon Moberg
Filed: 18 Nov 20
Utility
Heavy chain antibodies binding to CD22
16 Jan 24
Anti-CD22 heavy chain antibodies (e.g., UniAbs™) are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B cell disorders that are characterized by the expression of CD22.
Shelley Force Aldred, Wim van Schooten, Heather Anne N. Ogana, Laura Marie Davison, Katherine Harris, Udaya Rangaswamy, Nathan D. Trinklein
Filed: 21 Dec 18
Utility
Pharmaceutical formulations comprising anti-RANKL antibodies and an aromatic amino acid comprising a phenyl or an indole
16 Jan 24
Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors.
Stephen Robert Brych, Lyanne M. Wong, Jaymille Fallon, Monica Michelle Goss, Jian Hua Gu, Pavan K. Ghattyvenkatakrishna
Filed: 18 Nov 21
Utility
Protein biomarker and uses thereof
16 Jan 24
The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high.
Matthias Schneider, Sabine Blum, Renee Jeanne Mendell-Harary, Daniel J. Freeman, Robert Allen Beckman, Xiaoping Jin, Kimio Yonesaka, Kazuhiko Nakagawa
Filed: 21 Aug 19
Utility
Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases
9 Jan 24
Pingchen Fan, Christopher W. Lange, Rebecca M. Lui, Darren J. McMurtrie, Ryan J. Scamp, Ju Yang, Yibin Zeng, Penglie Zhang
Filed: 15 Oct 20
Utility
Anti-mesothelin binding proteins
9 Jan 24
The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin.
William Christian Fanslow, III, Carl Kozlosky, Jean Gudas
Filed: 6 Jan 21
Utility
C-terminal anti-sclerostin antibody variants
2 Jan 24
The invention generally relates to anti-sclerostin antibodies having C-terminal modifications, and compositions comprising such antibodies.
Zhe Huang, Jennitte LeAnn Stevens, Greg Flynn, Szilan Fodor, Mark Daris
Filed: 23 Sep 22
Utility
IL-17 receptor A antigen binding proteins
2 Jan 24
The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands.
Joel E. Tocker, Jacques J. Peschon, David Fitzpatrick, James F. Smothers, Christopher Mehlin, Ai Ching Lim
Filed: 5 Aug 20
Utility
Methods of treating hidradenitis suppurativa
19 Dec 23
Shijie Li, Rajinder Singh, Thomas J. Schall, Peter Staehr
Filed: 27 Oct 21
Utility
Processes and intermediates in the preparation of C5aR antagonists
19 Dec 23
Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
Pingchen Fan, Jaroslaw Kalisiak, Antoni Krasinski, Rebecca M. Lui, Jay Powers, Sreenivas Punna, Hiroko Tanaka, Penglie Zhang
Filed: 8 Feb 22
Utility
PRMT5 inhibitors
19 Dec 23
Shon Booker, Matthew Paul Bourbeau, John R. Butler, Sanne Ormholt Schroder Glad, Brian Alan Lanman, Patricia Lopez, Francesco Manoni, Liping H. Pettus, Ian Sarvary, Nuria A. Tamayo, Mikkel Vestergaard, Nicholas Anthony Weires
Filed: 15 Dec 21
Utility
Methods of treating non-alcoholic steatohepatitis using FGF21 mutants
12 Dec 23
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
Filed: 24 Jun 21
Utility
Nucleic acid biomarker and use thereof
12 Dec 23
The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high.
Matthias Schneider, Sabine Blum, Renee Jeanne Mendell-Harary, Daniel J. Freeman, Robert Allen Beckman, Xiaoping Jin
Filed: 21 Aug 19
Utility
CXCR7 antagonists
5 Dec 23
Junfa Fan, Antoni Krasinski, Christopher W. Lange, Rebecca M. Lui, Jeffrey P. McMahon, Jay P. Powers, Yibin Zeng, Penglie Zhang
Filed: 27 May 21
Utility
High titer recombinant AAV vector production in adherent and suspension cells
5 Dec 23
The present invention is directed to an in vitro method of producing a recombinant AAV virion in a mammalian host cell that comprises a functional adenoviral E1A gene (e.g., a HEK 293T cell) and rAAV virions made by the method.
Huiren Zhao, Grace Ki Jeong Lee, Thomas Wolfe, Cherylene Plewa, Jackie Z. Sheng
Filed: 28 Jul 21
Utility
Systems and approaches for sterilizing a drug delivery device
28 Nov 23
A drug delivery sterilization system includes a housing defining at least one receptacle, a container assembly having first and second ends, an elongated portion extending therebetween, and an electron beam or x-ray generator disposed near the housing.
Loic Barbedette, Shaun Devitt, Wael Mismar
Filed: 2 Nov 18
Utility
Systems and approaches for sterilizing a drug delivery device
28 Nov 23
An on-body injector system includes a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container.
Loic Barbedette, Shaun Devitt, Wael Mismar
Filed: 21 Dec 22