451 patents
Utility
Glucocorticoid Receptor Agonists
18 Jan 24
Adel Ahmed Rashad AHMED, Joshua Ryan CLAYTON, Jose Eduardo LOPEZ, William Thomas MCMILLEN, Ryan Edward STITES, Takako WILSON, Jacqueline Mary WURST
Filed: 8 Sep 23
Utility
Rapid-acting insulin compositions
16 Jan 24
The invention is a composition of human insulin or insulin analog that includes specific concentrations of citrate, chloride, in some cases including the addition of sodium chloride, zinc and, optionally, magnesium chloride and/or surfactant, and that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products.
Michael Patrick Akers, Chi A. Nguyen, Chad D. Paavola, Virender Kumar Sarin, Nanette Elizabeth Schulte, Ranajoy Majumdar
Filed: 17 Sep 21
Utility
Anti-CD11D antibodies and uses thereof
16 Jan 24
Antibodies to human CD11d, compositions comprising such CD11d antibodies, and methods of using such CD11d antibodies for the treatment of central nervous system trauma including spinal cord injury and traumatic brain injury, as well as systemic inflammatory response following central nervous system trauma.
Gregory Dekaban, Arthur Brown, Lynne Weaver, Allan Barrett, Kristine Kikly
Filed: 24 Feb 17
Utility
Devices and Processes for Delivery of Therapeutic Fluids
11 Jan 24
A therapeutic agent delivery system includes a therapeutic agent delivery assembly carried by a housing.
William Godwin ATTERBURY, Corrie Jo BENNISON, Yelena N. DAVIS, David Arthur HOLLEY, John Paul TALLARICO, Jessica Diane YOUNG
Filed: 1 Sep 21
Utility
ANTI-N3pGlu AMYLOID BETA ANTIBODIES AND USES THEREOF
11 Jan 24
The invention is directed to treatment or prevention of a disease characterized by deposition of Aβ in the brain using anti-N3pGlu Aβ antibodies.
Adam S. FLEISHER, Mark MINTUN, John Randall SIMS, II, JonDavid SPARKS
Filed: 11 Jan 22
Utility
Medication delivery device including disposable and reusable portions
9 Jan 24
A medication delivery device includes a disposable portion and a reusable portion.
Matthew David Backfish, Murat Günay
Filed: 22 Oct 21
Utility
Hub for Reusable Drug-delivery Device
4 Jan 24
A recharging and medication storage hub for a re-usable drug-delivery device is provided.
Alexander Joseph BAKER, Kevin Harrison DUFFY, Kaitlyn Mary EDDY, Dae Il KWON, Labi SHRESTHA, Rhea SIRKAR
Filed: 5 Jan 22
Utility
Medication delivery device with a sensed element
2 Jan 24
A medication delivery device including a device body and a dose setting component coupled to the device body.
Roy Howard Byerly, Timothy Mark Blum
Filed: 20 Feb 19
Utility
GITR antagonists and methods of using the same
2 Jan 24
The present disclosure relates to compounds that bind to human GITR, pharmaceutical compositions comprising such compounds, and methods of using such compounds.
Petra Verdino, Paul Francis Cain, Melinda Ann Lacerte, Stacey Lynn Lee, Mark Andrew Wortinger
Filed: 1 Feb 22
Utility
Methods for Reducing Host Cell Protein Content In Antibody Purification Processes and Antibody Compositions Having Reduced Host Cell Protein Content
21 Dec 23
The present disclosure relates to methods for reducing host cell protein content in antibody preparation recombinantly produced in a host cell in the manufacturing process of antibodies intended for administration to a patient.
Brian David BOWES, Lara Ellen KREBS, Lihua HUANG, Steven A. PLICHTA, Sarah M. RICHER
Filed: 4 Oct 21
Utility
Devices and Processes for Delivery of Therapeutic Fluids
14 Dec 23
A therapeutic agent delivery system includes a therapeutic agent delivery assembly carried by a housing.
William Godwin ATTERBURY, Timothy Mark BLUM, Yelena N. DAVIS, David Arthur HOLLEY, John Paul TALLARICO, Jessica Diane YOUNG
Filed: 1 Sep 21
Utility
Combination therapy
12 Dec 23
The present invention provides a method of treating a tau-mediated cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of an anti-Tau antibody and an effective amount of an OGA inhibitor.
Mansuo Lu Hayashi, Michael Carl Irizarry, Hugh Nuthall
Filed: 5 Jan 21
Utility
KCNQ potentiators
12 Dec 23
Small molecule potentiatiors to potassium channels (such as Kv7 potentiators—which are also called KCNQ potentiators), compositions including such compounds, and methods of using such compounds for the treatment of Amyotrophic Lateral Sclerosis and other neurological diseases caused by changes in motor neuron excitability, including, but not limited to, primary lateral sclerosis, pseudobulbar palsy, progressive bulbar palsy, progressive muscular atrophy and epilepsy.
Helen Jane Szekeres, Maria Ann Whatton, Andrew Caerwyn Williams
Filed: 19 Nov 21
Utility
Medication Delivery Device with Moisture Sensing System
7 Dec 23
Medication delivery devices are provided having a housing comprising a reservoir sized sufficiently to hold medication, a dose button being rotatable relative to the housing to select a dose size of the medication for an injection, a printed circuit board, a conductive trace, and a microcontroller.
Matthew James ASH, Emil PREDA, Andrew Eric BOWYER, Robert Eugene TRZYBINSKI
Filed: 19 Oct 21
Utility
cGAS INHIBITORS
7 Dec 23
The present invention relates to novel cGAS inhibitor compounds, to pharmaceutical compositions comprising the compounds, and to methods of using the compounds and compositions to treat certain pathological conditions.
Adel AHMED, Christina MARTINEZ BROKAW, Cheryl Ann CARSON, Scott E. CONNER, Kevin Charles FORTNER, Jeffry B. FRANCISKOVICH, Douglas L. GERNERT, Steven J. GREEN, Charles W. LUGAR, III, Jothirajah MARIMUTHU, Shanthi NAGARAJAN, Christodoulos NICOLAOU, Emmanuel ONOBUN, Stephanie Lange STOUT, Eric G. TROMICZAK, Thibault VARIN
Filed: 1 Jun 23
Utility
SSTR4 agonist salts
5 Dec 23
The present invention relates to specific salts of (1S,5R)-(1α,5α,6α)-N-[1,1-dimethyl-2-[(3-methyl-2-pyridyl)oxy]ethyl]-3-azabicyclo[3.1.0]hexane-6-carboxamide, to pharmaceutical compositions comprising said salts, to methods of using said salts to treat physiological disorders, and to intermediates useful in the synthesis of the salts.
David Andrew Coates, David Michael Remick
Filed: 14 Sep 22
Utility
Incretin analogs and uses thereof
5 Dec 23
Incretin analogs are provided that have activity at each of the GIP, GLP-1 and glucagon receptors.
Jorge Alsina-Fernandez, Tamer Coskun, Lili Guo, Hongchang Qu
Filed: 14 Dec 18
Utility
Oral Drug Delivery Device with Expanding Arms
30 Nov 23
The present disclosure provides a drug delivery device.
Maria Fernandez-Martos BALSON, Matthew Keith FORDHAM, Jack Alexander HORNSBY, Nikolaos Sotirios VASILAKIS, Sarah Louise CLARK
Filed: 15 Sep 21
Utility
Lasofoxifene Combination Treatment of Er+ Breast Cancer That Has Progressed on a CDK4/6 Inhibitor
30 Nov 23
Methods for reducing the progression of ER+ breast cancer in a patient are provided, the methods comprising administering to the patient an effective amount of lasofoxifene or a pharmaceutically acceptable salt thereof and an effective amount of a CDK4/6 inhibitor (CDK4/6i), wherein the breast cancer: (i) is estrogen receptor positive (ER+); (ii) has at least one gain of function missense mutation within the ligand binding domain (LBD) of the Estrogen Receptor 1 (ESR1) gene; and (iii) has progressed during prior CDK4/6 inhibitor therapy and/or has an oncogenic mutation in a gene other than ESR1.
David J. PORTMAN, Paul PLOURDE, Simon JENKINS
Filed: 25 May 23
Utility
Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators
30 Nov 23
Junliang HAO, Richard D. JOHNSTON, Gregory Lawrence LACKNER, Erik J. HEMBRE, Kjell A. SVENSSON
Filed: 5 Oct 21