451 patents
Page 6 of 23
Utility
Antibodies to IL-34
16 May 23
The present invention relates to IL-34 antibodies, compositions comprising the same, and methods of using the antibodies and or compositions thereof for treating immune-mediated diseases such as neurodegenerative diseases, for example Alzheimer's Disease or a tauopathy disease.
Marcio Chedid, Victor H. Obungu, Andrew Dixon Skora, Ming Ye
Filed: 23 Apr 21
Utility
Combination Therapy with a Mutant Idh Inhibitor
11 May 23
Nathan Arthur BROOKS, Raymond GILMOUR
Filed: 22 Mar 21
Utility
Drive assembly for moving piston within container
9 May 23
A drive assembly includes a drive ribbon that can be retracted and extended.
Jared Alden Judson, Timothy L. Moulton
Filed: 17 Dec 20
Utility
Conjugates for Selective Responsiveness to Vicinal Diols
4 May 23
Embodiments of the present disclosure relate to sensors that can selectively bind to specific vicinal diols in the presence of other diols.
Alborz MAHDAVI, Ryan Kelly SPENCER, Jack Joseph STEELE, JingXin LIANG, Mirna Ekram Anwar SHAKER, Diao CHEN, Sachitanand MALI
Filed: 31 Mar 21
Utility
Combination Therapy with a Mutant Idh Inhibitor and a BCL-2 Inhibitor
4 May 23
Nathan Arthur BROOKS, Courtney DINARDO, Raymond GILMOUR, Marina KONOPLEVA, Vivian SALAMA
Filed: 22 Mar 21
Utility
Substituted 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE Derivatives
4 May 23
Thomas John BLEISCH, Douglas Linn GERNERT, Freddie Craig STEVENS
Filed: 5 Feb 21
Utility
Processes and Intermediate for the Large-scale Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Hemisuccinate, and Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Acetate
4 May 23
The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-tri-fluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes.
Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
Filed: 6 Jul 20
Utility
Crystallization of Antibodies or Antigen-Binding Fragments
4 May 23
Provided herein are methods and compositions for improving the crystallization of antibodies, antigen-binding fragments, e.g., Fab or Fab′, or fusion proteins, and Fab/Fab′/mAb:Antigen complexes.
Shane Krummen Atwell, Ricky Long Lieu
Filed: 9 Feb 21
Utility
Medication delivery device with sensing system
2 May 23
Medication delivery devices are provided having a dose delivery sensing capability.
Roy Howard Byerly, Daniel Joseph Nelsen, Russell Wayne Perkins, Robert Charles Uschold
Filed: 3 Jun 22
Utility
Ahr Agonists
27 Apr 23
The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.
Cheryl Ann CARSON, Christian Alexander CLARKE, Douglas Linn GERNERT, Steven James GREEN, William Glen HOLLOWAY
Filed: 13 Sep 22
Utility
Substituted pyrazolo[1,5-a]pyrimidines as inhibitors of interferon signaling
25 Apr 23
Thomas John Bleisch, Zhaogen Chen, Theodore Curtis Jessop
Filed: 5 Feb 21
Utility
Selective estrogen receptor degraders
25 Apr 23
Jolie Anne Bastian, Jeffrey Daniel Cohen, Almudena Rubio, Daniel Jon Sall, Jennifer Anne McMahon
Filed: 2 Sep 21
Utility
Therapeutic antibody formulation
25 Apr 23
Stable aqueous pharmaceutical formulations for therapeutic antibodies and methods of using such stable aqueous pharmaceutical formulations.
Vincent John Corvari, Karthik Pisupati
Filed: 11 Feb 20
Utility
Dose Detection and Drug Identification for a Medication Delivery Device
20 Apr 23
The present disclosure relates to a dose detection system for use in combination with a medication delivery device.
Roy Howard BYERLY, Russell Wayne PERKINS, Rossano Claudio MASSARI, Patrick Kevin MURPHY, Davide PACCIORETTI, Sean Matthew PSZENNY, Oliver Brian REGELE
Filed: 20 Dec 22
Utility
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
18 Apr 23
Renato Alejandro Bauer, Serge Louis Boulet, Timothy Paul Burkholder, Raymond Gilmour, Patric James Hahn, Zoran Rankovic
Filed: 16 Mar 21
Utility
Dose Detection Module for a Medication Delivery Device
13 Apr 23
The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery.
Matthew Thomas ANTONELLI, William Churchill Taliaferro BURKE, Roy Howard BYERLY, Christopher Robert MCCASLIN, Ethan Edward PEASE, Kenneth Alan RITSHER
Filed: 13 Dec 22
Design
Display screen with a graphical user interface
11 Apr 23
Alec Michael Cerminaro, James Joseph Costigan, V, Faith Ilene Kaufman, Monika Paulaviciute
Filed: 21 Apr 21
Utility
Anti-human CD19 antibodies
11 Apr 23
The present disclosure relates to antibodies that bind human CD19 (“anti-human CD19 antibodies” or “anti-human CD19 antibodies”), compositions comprising such anti-human CD19 antibodies, and methods of using such anti-human CD19 antibodies.
Barrett Allan, Jeffrey Streetman Boyles, Alison Lee Sim Budelsky, Kira Vladimirovna Rubtsova, Guifeng Zhang, Songqing Na
Filed: 22 Feb 21
Utility
Carboxy substituted glucocorticoid receptor agonists
4 Apr 23
Ryan Edward Stites, Jacqueline Mary Wurst
Filed: 22 Mar 22
Utility
FGFR3 Inhibitor Compounds
30 Mar 23
Adedoyin David ABRAHAM, Desta Doro BUME, Kevin Ronald CONDROSKI, Robert Alan HAZLITT, Timothy Scott KERCHER, Andrew Terrance METCALF, Kaveri Balan URKALAN, Shane Michael WALLS, Andrew Karl DILGER
Filed: 3 Mar 22