79 patents
Utility
Method and system for self-regulating a suppressor
2 Jan 24
A system for self-regulating a suppressor includes an ion chromatography suppressor, a power supply for applying an electric potential to the suppressor, and a control unit configured to provide an offset voltage VOS and an applied voltage VA to the suppressor, measure a current of the suppressor responsive to the offset and applied voltages VOS and VA, determine a suppressor state of the suppressor based upon the measured current, and adjust the offset voltage VOS based upon the suppressor state.
Akinde F. Kadjo
Filed: 21 Dec 21
Utility
Anion exchange stationary phases based on a polyalkylpolyamine polymer layer
19 Dec 23
An anion exchange for separating a plurality of carbohydrates includes a negatively charged substrate particle.
Christopher A. Pohl, Jinhua Chen
Filed: 15 Feb 21
Utility
Method of separating viral vectors
21 Nov 23
A method of separating a liquid sample containing viral vectors includes flowing the liquid sample into an anion exchange column.
Kenneth George Cook, Alexander Boris Schwahn, Jung Un Baek, Shanhua Lin Liehr
Filed: 10 Nov 20
Utility
Chromatographic material having improved pH stability, method for preparation thereof and uses thereof
14 Nov 23
A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group.
Xiaodong Liu, Xiao Cui, Xuefei Sun
Filed: 11 Jan 21
Utility
Monitoring and preventing suppressor failures
31 Oct 23
The eluent used in IC separation contains non-volatile salt which is not compatible with electrospray ionization-mass spectrometry (ESI-MS).
Yongjing Chen
Filed: 8 Dec 21
Utility
System for Electrospray Ionization with Integrated LC Column and Electrospray Emitter
26 Oct 23
An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis.
Brandon Howard Robson, Xuefei Sun, Carla Marie Medlin, Shane Bechler
Filed: 26 Jun 23
Utility
Monitoring and Mitigating Suppressor Failure
26 Oct 23
A suppressor comprising one or more channels, a flow path for each of the channels, and one or more measurement probes positioned in the flow path is described.
Yongjing Chen, Yan Liu
Filed: 20 Mar 23
Utility
Bioinert sampling needle
3 Oct 23
A sampling needle is provided for piercing a septum of a vial containing a sample and aspirating the sample from the vial.
Daniel Hoffmeyer, Licheng Tseng
Filed: 29 Dec 20
Utility
Replaceable emitter assembly for interfacing a separation column to a mass spectrometer
3 Oct 23
An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed.
Brandon Howard Robson, Xuefei Sun, Xiaodong Liu
Filed: 24 May 21
Utility
Extraction Cell Cap Assembly with Toolless Disassembly
31 Aug 23
An extraction cell cap assembly allows for toolless disassembly.
Weichiat Chen, Kannan Srinivasan
Filed: 10 May 23
Utility
Automated valve switching setup for ion chromatography (IC) that facilitates equilibration of consumables or allows for normal IC operation
22 Aug 23
A chromatography system includes an electrolytic eluent generator; a first valve configured to switch between an operating position which directs an output of the electrolytic eluent generator to a continuously generated trap column and a waste position which directs the output of the electrolytic eluent generator to waste; the continuously regenerated trap column; a degasser; a sample injector including a sample injector valve assembly, the sample injector valve assembly configured to switch between an operation mode which directs an output of the degasser to a separation column, a load mode which loads a sample onto the separation column, and a regenerant mode which directs the output of the degasser to a regenerant line; the separation column; a suppressor; and a detector.
Kannan Srinivasan
Filed: 8 Sep 21
Utility
Configuration for Ultra High Pressure Electrolytic Eluent Generators
6 Jul 23
An electrolytic eluent generator includes an electrolyte reservoir and at least one eluent generation cartridge.
Zhongqing Lu, Yan Liu, Angelo Rubero, Rong Lin
Filed: 30 Dec 21
Utility
Identification of Sample Cells In a Chromatography Autosampler
29 Jun 23
Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler.
Daniel Hoffmeyer, Husam Al-Esawi, Tobias Metz, Til Richardsen, Christoph Hollnagel
Filed: 28 Dec 21
Utility
Identification of Sample Cells In a Chromatography Autosampler
29 Jun 23
Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler.
Daniel Hoffmeyer, Husam Al-Esawi, Tobias Metz, Til Richardsen, Christoph Hollnagel
Filed: 24 Feb 22
Utility
Extraction cell cap assembly with toolless disassembly
27 Jun 23
An extraction cell cap assembly allows for toolless disassembly.
Weichiat Chen, Kannan Srinivasan
Filed: 30 Sep 20
Utility
Electrolytic Buffer Generator
4 May 23
Buffer generators are described based on electrodialytic devices.
Purnendu K. Dasgupta, Yongjing Chen, Kannan Srinivasan
Filed: 6 Sep 22
Utility
Electrolytic Eluent Generators with Stabilized Operating Voltages
30 Mar 23
An electrolytic eluent generator includes an electrolyte reservoir, an eluent generation chamber, and an ion exchange membrane stack.
Zhongqing LU, Yan LIU, Christopher A. POHL, Jinhua CHEN, Jun CHENG
Filed: 4 Nov 22
Utility
Self-directed Computer System Validation
16 Mar 23
A system for self-directed computer system validation includes first logic to provide a graphical user interface to enable a user to select a set of selected requirements from a plurality of available requirements; second logic to select a set of procedures to satisfy the need to test against each of the requirements and document evidence of the outcomes and generate a set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system; and third logic to provide the set of documents for installing and configuring the system and test protocols including all methods and objects needed to validate the system.
Shaun Anders QUINN, Matthew A. GRULKE, Patrick Michael KENNY
Filed: 13 Sep 21
Utility
Novel Automated Valve Switching Setup for Ion Chromatography (IC) that Facilitates Equilibration of Consumables or Allows for Normal IC Operation
9 Mar 23
A chromatography system includes an electrolytic eluent generator; a first valve configured to switch between an operating position which directs an output of the electrolytic eluent generator to a continuously generated trap column and a waste position which directs the output of the electrolytic eluent generator to waste; the continuously regenerated trap column; a degasser; a sample injector including a sample injector valve assembly, the sample injector valve assembly configured to switch between an operation mode which directs an output of the degasser to a separation column, a load mode which loads a sample onto the separation column, and a regenerant mode which directs the output of the degasser to a regenerant line; the separation column; a suppressor; and a detector.
Kannan SRINIVASAN
Filed: 8 Sep 21
Utility
Check Standard Recycle Setup for Ion Chromatography
9 Mar 23
An ion chromatography system includes a separation column configured to separate components of a solution; a non-destructive detector; and a concentrator configured to capture components of a check standard after they leave the conductivity non-destructive detector; and release the components of the check standard to the separation column.
Kannan SRINIVASAN
Filed: 9 Sep 21