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RGEN Repligen

GRANT
Utility
Slope spectroscopy standards
12 Oct 21
The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements.
Mark Salerno, I-Tsung Shih, Craig Harrison
Filed: 9 Nov 20
APP
Utility
Methods, Devices and Systems for 3-STAGE Filtration
16 Sep 21
The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.
Michael Bransby
Filed: 27 May 21
GRANT
Utility
Flexible tubing management system for pharmaceutical, bioprocess applications, and food/dairy applications
7 Sep 21
A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks.
Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
Filed: 18 Feb 20
APP
Utility
Encapsulated Valve System and Method of Use
19 Aug 21
An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface.
Michael C. Gagne, Steven V. Cates
Filed: 3 May 21
APP
Utility
Fluid Monitoring Assembly with Sensor Functionality
29 Jul 21
A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid.
Michael C. Gagne, Steven V. Cates, Dean C. Richards, Scott Bendon
Filed: 13 Apr 21
APP
Utility
Tangential Flow Depth Filtration Systems and Methods of Filtration Using Same
15 Jul 21
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 31 Mar 21
APP
Utility
Alkaline Stable Fc-binding Proteins for Affinity Chromatography
8 Jul 21
The present invention relates to Fc binding proteins comprising one or more Fc binding domains wherein at least one domain comprises of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-6 or 21.
Paul Knick, Erik Fiedler, Ulrich Haupts, Maren Meysing
Filed: 23 Mar 21
APP
Utility
Filtration Cassette Residing In Bag and Methods of Using Same
1 Jul 21
Tangential flow filtration systems utilizing flexible bags for permeate collection are provided.
Mark A. PERREAULT
Filed: 24 Nov 20
GRANT
Utility
Methods, devices and systems for 3-stage filtration
8 Jun 21
The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.
Michael Bransby
Filed: 7 May 18
GRANT
Utility
Tangential flow depth filtration systems and methods of filtration using same
1 Jun 21
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 5 Aug 20
GRANT
Utility
Encapsulated valve system and method of use
1 Jun 21
An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface.
Michael C. Gagne, Steven V. Cates
Filed: 5 Feb 19
GRANT
Utility
Alkaline stable Fc-binding proteins for affinity chromatography
25 May 21
The present invention relates to Fc binding proteins comprising one or more Fc binding domains wherein at least one domain comprises of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-6 or 21.
Paul Knick, Erik Fiedler, Ulrich Haupts, Maren Meysing
Filed: 7 Aug 17
GRANT
Utility
Fluid monitoring assembly with replaceable sensor functionality
25 May 21
A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid.
Michael C. Gagne, Steven V. Cates, Dean Richards, Scott Bendon
Filed: 13 Sep 19
APP
Utility
Fluid Plug for Sterile Processes and Methods of Using the Same
6 May 21
A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed.
Michael C. Gagne
Filed: 13 Jan 21
APP
Utility
Determination of Protein Concentration In a Fluid
1 Apr 21
The present disclosure provides systems and methods that allow users to quickly determine titer and remove hold steps by determining a first concentration using slope spectroscopy, depleting the fluid of the expressed protein by selective adsorption, and determining a second concentration using slope spectroscopy.
James Ronald Peyser, Ramsey Shanbaky
Filed: 1 Oct 20
APP
Utility
Scale-down Tangential Flow Depth Filtration Systems and Methods of Filtration Using Same
11 Mar 21
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 3 Sep 20
APP
Utility
FC Binding Proteins with Cysteine In the C-terminal Helical Region
25 Feb 21
The present invention relates to Fc binding proteins comprising one or more domains with Cysteine in the C-terminal helical region.
Erik Fiedler, Ulrich Haupts
Filed: 28 Jan 19
APP
Utility
Slope Spectroscopy Standards
25 Feb 21
The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements.
Mark Salerno, I-Tsung Shih, Craig Harrison
Filed: 9 Nov 20
APP
Utility
Control systems and methods for automated clarification of cell culture with high solids content
18 Feb 21
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing applications, systems employing such filters, and methods of filtration using the same.
Derek Carroll, Michael Bransby, Philip Yuen
Filed: 13 Aug 20
APP
Utility
Devices, Systems, and Methods for Continuous Processing with Alternating Tangential Flow
11 Feb 21
The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Mark A. Perreault
Filed: 28 Jul 20
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