779 patents
Page 11 of 39
Utility
EZH2 inhibitor combination therapies
20 Dec 22
This invention relates to combination therapies comprising an EZH2 inhibitor and a chemotherapeutic agent, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses.
Manfred Kraus, Pei-Pei Kung, Thomas Andrew Paul, Shikhar Sharma, Dominique Verhelle
Filed: 9 Nov 18
Utility
Piperazine azaspiro derivatives
13 Dec 22
Lei Zhang, Erik Alphie LaChapelle, Christopher Ryan Butler, Natasha Mariam Kablaoui, Michael Aaron Brodney, Laura Ann McAllister, Qingyi Yang, Christopher John Helal, Damien Webb
Filed: 25 Mar 19
Utility
Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors
13 Dec 22
James F. Blake, Donghua Dai, Julia Haas, Yutong Jiang, Gabrielle R. Kolakowski, Andrew T. Metcalf, David A. Moreno, Brett Prigaro, Li Ren
Filed: 18 Jan 19
Utility
Antibodies specific for GUCY2c and uses thereof
13 Dec 22
The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer.
Chew Shun Chang, Gurkan Guntas, Madan Katragadda, Divya Mathur, Adam Reid Root, Lidia Mosyak, Edward Roland LaVallie
Filed: 21 May 19
Utility
Combinations Comprising Benzodioxol As GLP-1R Agonists for Use In the Treatment of Nash/nafld and Related Diseases
8 Dec 22
In part, the invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist.
Gary E. Aspnes, Scott W. Bagley, John M. Curto, Matthew Dowling, David James Edmonds, Dilinie Fernando, Mark E. Flanagan, Kentaro Futatsugi, David Andrew Griffith, Kim Huard, Gajendra Ingle, Wenhua Jiao, Shawn M. LaCasse, Yajing Lian, Chris Limberakis, Allyn T. Londregan, Alan M. Mathiowetz, David Walter Piotrowski, Roger B. Ruggeri, Kristin Wiglesworth
Filed: 15 May 20
Utility
Immunogenic Compositions Comprising Conjugated Capsular Saccharide Antigens and Uses Thereof
8 Dec 22
The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.
Annaliesa Sybil Anderson, Caitlyn Gallagher, Jianxin Gu, Isis Kanevsky, Jin-Hwan Kim, Justin Keith Moran, Suddham Singh, Naveen Surendran
Filed: 25 May 22
Utility
Tumor Necrosis Factor-like Ligand 1A Specific Antibodies and Compositions and Uses Thereof
8 Dec 22
The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to tumor necrosis factor (TNF)-like ligand (TL1A).
Robert ARCH, Jun ZHANG, Michelle MADER, Tetsuya ISHINO, Joel BARD, William FINLAY, Orla CUNNINGHAM, Ciara REILLY, Peter BRAMS, Brigitte DEVAUX, Haichun HUANG, Karla HENNING
Filed: 28 Jul 22
Utility
Immunogenic Compositions Comprising Conjugated Capsular Saccharide Antigens and Uses Thereof
8 Dec 22
The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.
Annaliesa Sybil Anderson, Caitlyn Gallagher, Jianxin Gu, Isis Kanevsky, Jin-Hwan Kim, Justin Keith Moran, Suddham Singh, Naveen Surendran
Filed: 25 May 22
Utility
1-(((2S,3S,4S)-3-ETHYL-4-FLUORO-5-OXOPYRROLIDIN-2-YL)METHOXY)-7-METHOXYISOQUINOLINE-6-CARBOXAMIDE Combinations and Oral Dosage Forms
1 Dec 22
The present invention is related to the discovery of new oral dosage formulations and combination therapies for 1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide, or a pharmaceutically acceptable salt thereof, for treating conditions ameliorated by inhibition of IRAK4.
Allan Joseph Hutchins, Bruce Clinton MacDonald, Vikram Rama Rao, Degui Tang, Weili Yu
Filed: 11 Nov 20
Utility
Streptococcus Pneumoniae Capsular Polysaccharides and Conjugates Thereof
1 Dec 22
The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation.
Jianxin Gu, Rajesh Kumar Kainthan, Jin-Hwan Kim, Avvari Krishna Prasad, Yu-Ying Yang
Filed: 22 Jul 22
Utility
Methods and Intermediates for Preparing Hydrochloride Salt of 5-[3-(3-HYDROXYPHENOXY)AZETIDIN-1-YL]-5-METHYL-2,2-DIPHENYLHEXANAMIDE
1 Dec 22
Methods for providing a carboxamide compound and intermediates used in the preparation of the carboxamide compound are provided.
Vadali Lakshmana Rao, Saidugari Swamy, Nagaraju Mittapelly, Dasari Srinivasa Rao, Sarah Haycock Lewandowski, Alan Pettman
Filed: 24 Jun 20
Utility
ANTI-GDF15 Antibodies, Compositions and Methods of Use
1 Dec 22
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
Kevin Charles Beaumont, Danna M. Breen, Matthew Allister Lambert, Jeffrey Raymond Chabot, Tao He, Ksenya Shchors, James R. Apgar
Filed: 1 Aug 22
Utility
GLP-1 receptor agonists and uses thereof
29 Nov 22
Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
Gary Erik Aspnes, Scott W. Bagley, John M. Curto, Matthew S. Dowling, David Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Gajendra Ingle, Wenhua Jiao, Chris Limberakis, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
Filed: 30 Oct 20
Utility
Combination Treatments Of Cancer Comprising A TLR Agonist
24 Nov 22
The present disclosure describes combination therapies and uses thereof for the treatment of cancer.
Shih-Hsun CHEN, Luca MICCI, Cecilia Marianne ODERUP, Shahram SALEK-ARDAKANI, Jie WEI
Filed: 18 Dec 19
Utility
Filling Head for Powered Layering of a Dry Powder Inhaler
24 Nov 22
A filling head (20) for filling a container (22) includes a receptacle (24).
Simon Cooper, Bruce MacMichael, Peter Houzego
Filed: 24 Jun 20
Utility
Treatment of brain cancer
22 Nov 22
Compounds for the treatment of brain cancer are provided herein.
Patrice A. Lee, Shannon L. Winski, Kevin Koch
Filed: 2 May 19
Utility
5-(Thiophen-2-YL)-1 H-Tetrazole Derivative as BCKDK Inhibitors Useful for Treating Various Diseases
17 Nov 22
Samit Kumar Bhattacharya, Christopher Ryan Butler, Kevin James Filipski, Bethany Lyn Kormos, Luis Angel Martinez-Alsina, Russell Alan Miller, Kiyoyuki Omoto, Brian Raymer, Matthew Richard Reese, Rachel Jane Roth Flach, Yuan Zhang
Filed: 24 Jun 20
Utility
Immunogenic Composition Against Influenza
17 Nov 22
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.
Philip Ralph Dormitzer, Advait Vijay Badkar, Christina Van Geen Hoven, Kathrin Ute Jansen, Pirada Suphaphiphat Allen, Ramin Darvari, Mark Duda
Filed: 29 Apr 22
Utility
Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272
10 Nov 22
A combination of temsirolimus and trastuzumab in the treatment of cancer is provided.
Laurence Moore, Charles Michael Zacharchuk, Sridhar Krishna Rabindran
Filed: 10 Dec 21
Utility
Benzisoxazole sulfonamide derivatives
8 Nov 22
Ylva Elisabet Bergman Bozikis, Michelle Ang Camerino, Pei-Pei Kung, Paul Anthony Stupple, Scott Channing Sutton
Filed: 16 Jun 20