779 patents
Page 3 of 39
Utility
Solid State Forms of (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE and Uses Thereof
30 Nov 23
The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.
Elaine GREER, Stephen ANDERSON, Mark MALONEY, Shu YU, Ekaterina ALBERT, Emily RIGSBEE
Filed: 28 Jul 23
Utility
Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes)
30 Nov 23
Martin James WYTHES, Indrawan James MCALPINE, Ryan PATMAN, Eugene Yuanjin RUI, Andrew FENSOME, Andreas MADERNA, Mehran JALAIE, Ketan S. GAJIWALA
Filed: 24 Jul 23
Utility
Methods for purifying bacterial polysaccharides
30 Nov 23
The present invention relates to methods for purifying bacterial polysaccharides, in particular for removing impurities from cellular lysates of bacteria producing polysaccharides.
Elizabeth BARANYI, Wei CHEN, Zecheng CHEN, Justin Keith MORAN, Yonghui YUAN
Filed: 19 Oct 21
Utility
Kras G12C Inhibitors
23 Nov 23
The present invention relates to compounds that inhibit KRas G12C.
Matthew Arnold MARX, James Gail CHRISTENSEN, Christopher Ronald SMITH, James F. BLAKE, Laurence E. BURGESS, Mark Joseph CHICARELLI, Adam COOK, Jay Bradford FELL, John P. FISCHER, Macedonio J. MEJIA, Martha E. RODRIGUEZ, Pavel SAVECHENKOV, Tony P. TANG, Guy P.A. VIGERS
Filed: 21 Oct 22
Utility
Solid state forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide and uses thereof
21 Nov 23
The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.
Elaine Greer, Stephen Anderson, Mark Maloney, Shu Yu, Ekaterina Albert, Emily Rigsbee
Filed: 27 Jan 23
Utility
Use Of Perfusion To Enhance Production Of Fed-batch Cell Culture In Bioreactors
16 Nov 23
The invention relates to methods of improving protein production, e.g., large-scale commercial protein production, e.g., antibody production, utilizing a modified fed-batch cell culture method comprising a cell growth phase and a polypeptide production phase.
Gregory Walter HILLER
Filed: 26 Jul 23
Utility
Anti-lymphotoxin Beta Receptor Antibodies and Methods of Use Thereof
16 Nov 23
Antibodies that specifically bind to LTBR are provided.
James Reasoner APGAR, Bas Joannes Gertrudis BAATEN, Aruna BITRA, Javier Fernando CHAPARRO RIGGERS, Giuseppe DI CARO, Pawel Kamil DOMINIK, Zachary John MABEN, Lidia MOSYAK, Andrew Ross NAGER, Cecilia Marianne ODERUP, Edward Derrick PASCUA, Shahram SALEK-ARDAKANI, Dirk Michael ZAJONC
Filed: 10 May 23
Utility
Benzodiazepine Derivatives Useful In Treating a Respiratory Syncytial Virus Infection
16 Nov 23
Matthew BARRETT, George Stuart COCKERILL, James GOOD, Craig Alex AVERY, Edward James COCHRANE, Stuart Thomas ONIONS, Andrew Joseph WARNER
Filed: 7 Jul 21
Utility
Therapeutic antibodies and their uses
14 Nov 23
The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3).
Tracy Chia-Chien Kuo, Javier Fernando Chaparro Riggers, Wei Chen, Amy Shaw-Ru Chen, Edward Derrick Pascua, Thomas John Van Blarcom, Leila Marie Boustany, Weihsien Ho, Yik Andy Yeung, Pavel Strop, Arvind Rajpal
Filed: 27 Aug 20
Utility
Glycoconjugation Processes and Compositions
9 Nov 23
The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
Jianxin Gu, Jin-hwan Kim, Avvari Krishna Prasad, Yu-ying Yang
Filed: 21 Jun 23
Utility
Solid Forms of a CDK4 Inhibitor
9 Nov 23
This invention relates to crystalline and amorphous forms of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-D-threo-pentitol, to pharmaceutical compositions comprising such solid forms, and to use of such solid forms and pharmaceutical compositions for the treatment of cancer.
Wesley Dewitt CLARK, Judith Gail DEAL, Brian Matthew SAMAS
Filed: 13 Sep 21
Utility
Kras G12D Inhibitors
9 Nov 23
The present invention relates to compounds that inhibit KRas G12D.
Xiaolun Wang, Matthew Arnold Marx, Shelley Allen, Mark Joseph Chicarelli, Joshua Ryan Dahlke, Donghua Dai, Jay Bradford Fell, John Peter Fischer, Michael Christopher Hilton, Dean Russell Kahn, Macedonio Junior Mejia, Phong Nguyen, Spencer Pajk, Martha E. Rodriguez, Pavel Yu Savechenkov, Tony Pisal Tang
Filed: 21 Sep 21
Utility
Antibodies and Antibody-drug Conjugates Specific for CD123 and Uses Thereof
9 Nov 23
The present invention provides antibodies that specifically bind to CD123.
Manoj Baburao CHARATI, Yoon-Chi HAN, Madan KATRAGADDA, Nicole Melissa PICHÉ-NICHOLAS, Lawrence Nathan TUMEY
Filed: 8 Mar 23
Utility
Process for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
7 Nov 23
Charles Todd Eary, Stacey Spencer, Zack Crane, Katelyn Chando, Sylvie Asselin, Weidong Liu, Mike Welch, Adam Cook, Gabrielle R. Kolakowski, Andrew T. Metcalf, David A. Moreno, Tony P. Tang
Filed: 13 Aug 21
Utility
Group B Streptococcus Polysaccharide-protein Conjugates, Methods for Producing Conjugates, Immunogenic Compositions Comprising Conjugates, and Uses Thereof
2 Nov 23
The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%.
Annaliesa Sybil Anderson, Amardeep Singh Bhupender Bhalla, Robert G.K. Donald, Jianxin Gu, Kathrin Ute Jansen, Rajesh Kumar Kainthan, Lakshmi Khandke, Jin-Hwan Kim, Paul Liberator, Avvari Krishna Prasad, Mark Edward Ruppen, Ingrid Lea Scully, Suddham Singh, Cindy Xudong Yang
Filed: 1 Dec 22
Utility
GLP-1 receptor agonists and uses thereof
31 Oct 23
Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
Gary Erik Aspnes, Scott W. Bagley, John M. Curto, Matthew S. Dowling, David Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Gajendra Ingle, Wenhua Jiao, Chris Limberakis, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
Filed: 24 Oct 22
Utility
Antibodies to MAdCAM
31 Oct 23
The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM.
Karin Anderson
Filed: 4 Jun 21
Utility
3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-diones as MEK inhibitors
31 Oct 23
Shelley Allen, Patrick Michael Doerner Barbour, James Francis Blake, Mark Laurence Boys, Joshua Ryan Dahlke, Alex Andrew Kellum, David Austin Moreno, Jacob Matthew O'Leary, Li Ren
Filed: 30 Mar 22
Utility
Stable Immediate Release Tablet and Capsule Formulations of 1-((2S,5R)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino)-2-Methylpiperidin-1-YL)Prop-2-EN-1-One
26 Oct 23
Andrew Richard Barrett, Ian Leonard Smales, Rand Dhiyaa Turki, Suet Mei Wong
Filed: 29 Dec 20
Utility
ANTI-IL-2 Antibodies and Compositions and Uses Thereof
26 Oct 23
The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ.
Isaac J. Rondon, Natasha Crellin, Paul Bessette, Eleonora Trotta, Jeffrey A. Bluestone, Lauren K. Ely, Kenan C. Garcia
Filed: 16 Sep 22