9 patents
Utility
Treatment of Cancer Using Inhibitors of Tgf-beta and PD-1
28 Dec 23
The present disclosure relates, in general, to combination therapy using an inhibitor of transforming growth factor beta (TGFβ) and an inhibitor of programmed cell death protein 1 (PD-1) for treating cancer or preventing recurrence of cancer diseases such as lung cancer, prostate cancer, breast cancer, hepatocellular cancer, esophageal cancer, colorectal cancer, pancreatic cancer, bladder cancer, kidney cancer, ovarian cancer, stomach cancer, fibrotic cancer, glioma and melanoma, and metastases thereof.
Amer M Mirza, Rosemary J. Akhurst, Ou Li
Filed: 11 May 23
Utility
Compositions and Methods for Delaying the Incidence of Labor
23 Nov 23
The invention provides compositions and methods for delaying the onset of delivery in a pregnant subject, such as a pregnant human subject, that is undergoing or at risk of undergoing preterm labor at a gestational age of from about 24 weeks to about 34 weeks.
Jean-Pierre GOTTELAND, Oliver POHL
Filed: 16 Dec 22
Utility
Novel Modulators
21 Jul 22
Antibodies that modulate insulin receptor signaling are provided.
John Corbin, Mark Leslie White, Susan R. Watson, Vinay Bhaskar
Filed: 13 Jan 22
Utility
Antibodies Specific for TGF-Beta
18 Nov 21
The present disclosure relates, in general, to materials and methods for antibodies specific for transforming growth factor beta (TGFβ), including TGFβ1, TGFβ2 and TGFβ3, and uses of these antibodies in the treatment of subjects having cancer, an eye disease, condition or disorder, fibrosis, including ophthalmic fibrosis or fibrosis of the eye, and other conditions or disorders related to TGFβ expression.
Daniel H. Bedinger, Shireen S. Khan, Amer M. Mirza, Ajay J. Narasimha, Toshihiko Takeuchi
Filed: 15 Jul 21
Utility
Antibodies That Bind INTERLEUKIN-2 and Uses Thereof
24 Jun 21
The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2 activity and use in the treatment of conditions such as cancer, autoimmune disease, or infection.
Marina Roell, Mark Rubinstein, Hassan Issafras, Llewelyn Lao, Ou Li, Daniel H. Bedinger, Kristin Camfield Lind, Agnes Choppin Holmes, Toshihiko Takeuchi, Lauren Schwimmer, Hoa Giang, Amer M. Mirza, Kirk W. Johnson
Filed: 4 Dec 20
Utility
Methods for the Treatment of Gout
4 Feb 21
Disclosed are methods for the treatment and/or prevention of gout, comprising administering to a subject an effective amount of anti-IL-1β antibody or fragment thereof.
Alan M. Solinger
Filed: 13 Mar 20
Utility
Cardiovascular Related Uses of IL-1BETA Antibodies and Binding Fragments Thereof
14 Jan 21
Disclosed are methods for the reduction, prevention or treatment of cardiovascular events and/or cardiovascular diseases, including acute cardiovascular disease or chronic cardiovascular disease using anti-IL-1β binding molecules (e.g., IL-1β binding antibodies and fragments thereof).
Patrick J. Scannon, Alan M. Solinger, Jeffrey D. Feldstein
Filed: 24 Feb 20
Utility
Parathyroid Hormone Receptor 1 (PTH1R) Antibodies and Uses Thereof
7 Oct 20
The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.
Raphael D. Levy, Hassan Issafras, Agnes Choppin Holmes, Kirk W. Johnson, Amer M. Mirza, Daniel H. Bedinger, Rachel A. Hunt, Toshikiko Takeuchi, Kiranjit Kaur Ahluwalia, Robyn Cotter
Filed: 25 Nov 19
Utility
Treatment of Cancer Using Inhibitors of TGF-Beta and PD-1
30 Sep 20
The present disclosure relates, in general, to combination therapy using an inhibitor of transforming growth factor beta (TGFβ) and an inhibitor of programmed cell death protein 1 (PD-1) for treating cancer or preventing recurrence of cancer diseases such as lung cancer, prostate cancer, breast cancer, hepatocellular cancer, esophageal cancer, colorectal cancer, pancreatic cancer, bladder cancer, kidney cancer, ovarian cancer, stomach cancer, fibrotic cancer, glioma and melanoma, and metastases thereof.
Amer M. Mirza, Rosemary J. Akhurst, Ou Li
Filed: 14 Jun 20
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