34 patents
Utility
Anti-severe Acute Respiratory Syndrome Coronavirus Antibodies
21 Dec 23
Anti-SARS-CoV-specific monoclonal antibodies, methods of making and characterizing those antibodies, and methods of using those antibodies are described herein.
Christine Andrea Goetz, Jody Bonnevier, Christopher David Hammerbeck, Ernesto Rubin Resnik, Cyrus B. Munshi, Enqing Tan
Filed: 24 Nov 21
Utility
Compounds that modulate the interaction of VISTA and VSIG3 and methods of making and using
17 Oct 23
Described herein are polyclonal and monoclonal antibodies that binds to VSIG3, compounds that modulate the interaction of VISTA and VSIG3, and methods of making and using the polyclonal and monoclonal antibodies and compounds.
Christine Goetz, Christopher Hammerbeck, Christopher Valley, Jody Bonnevier, Birte Aggeler, Jinghua Wang, Guoping Wu, Vassilios Kalabokis, Jose Fernando Bazan
Filed: 1 Feb 19
Utility
Methods to further enhance signal amplification for the in situ detection of nucleic acids
17 Oct 23
The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.
Yuling Luo, Xiao-Jun Ma, Steve Chen, Nan Su, Emerald Doolittle, Bingqing Zhang, Xiaoming Wang, Xingyong Wu, Xiao Yan Pimentel, Helen Jarnagin
Filed: 8 Apr 19
Utility
Methods and Compositions for Removal of Rna
5 Oct 23
The present disclosure provides compositions and methods related to the removal of RNA from a sample, and the preparation of samples for detection of DNA.
Farzaneh Tondnevis, Li-Chong Wang, Bingqing Zhang, Xiao-Jun Ma
Filed: 17 Sep 21
Utility
Compositions and Methods for Determining T Cell Clonality
21 Sep 23
The present disclosure provides compositions and methods related to the detection of mRNA variants.
Xiao-Jun Ma, Wei Wei, Brenda Nguyen, Niyati Jhaveri, Alisa Baker, Robert Monroe, Bingqing Zhang
Filed: 19 Aug 21
Utility
Methods of Detecting Nucleic Acids In Individual Cells and of Identifying Rare Cells from Large Heterogeneous Cell Populations
18 May 23
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to nucleic acid are provided.
Yuling Luo, Shiping Chen
Filed: 14 Oct 22
Utility
Methods for Detecting Target Nucleic Acids by In Situ Hybridization and a Kit Thereof
18 May 23
A method of detecting target nucleic acids, including small non-coding RNAs (sncRNAs), microRNAs (miRNAs), small interfering RNAs (siRNAs), PIWI-interacting RNA (piRNA), or antisense oligonucleotides (ASO) molecules, in a cell, comprising a post-fixation step using an aldehyde-containing fixative after the initial fixation step prior to in situ hybridization.
Miguel Angel Mata, Aparna Sahajan, Xiao-Jun Ma, Bingqing Zhang, Li Wang, Li-Chong Wang
Filed: 5 Apr 21
Utility
Identification of VSIG3/VISTA as a novel immune checkpoint and use thereof for immunotherapy
16 May 23
The ligand for VISTA is identified (VSIG3) as well as the use of this ligand and receptor interaction in the identification or synthesis of a VSIG3 agonist or antagonist compounds, preferably antibodies, polypeptides and fusion proteins which agonize or antagonize the effects of VSIG3 and/or VISTA and/or the VSIG3/VISTA interaction.
Vassilios Kalabokis, Jinghua Wang, Guoping Wu, Jose Fernando Bazan, Christopher Carlin Valley
Filed: 3 Aug 17
Utility
METHODS OF USING A TGF-beta KNOCKOUT CELL LINE AND COMPOSITIONS RESULTING THEREFROM
11 May 23
This disclosure describes protein compositions including minimal TGFβ1 contamination, methods for making those protein compositions, and methods for using those protein compositions.
Anthony D. Person, John E. Humphrey
Filed: 23 Mar 21
Utility
Apparatus and System for Nucleic Acid Detection
11 May 23
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided.
Shiping Chen, Yuling Luo
Filed: 14 Oct 22
Utility
Methods for Detecting NTRK Gene Fusion Using Rna In Situ Hybridization
23 Mar 23
A method of detecting a neurotrophic tyrosine receptor kinase (NTRK) fusion gene, comprising obtaining a sample and detecting a NTRK fusion gene in the sample by RNA in situ hybridization using a probe comprising a nucleic acid sequence complementary to a region of mRNA encoding a kinase domain of NTRK1, NTRK2, or NTRK3.
Xiao-Jun Ma, Robert J. Monroe, David T. Ting, Miguel N. Rivera, Vikram Deshpande, Azfar Neyaz, Baris Boyraz
Filed: 24 Feb 21
Utility
Methods for Sequential Detection of Nucleic Acids
5 Jan 23
The invention relates to methods of multiplex detection of a plurality of target nucleic acids by contacting a sample with an acid reagent to remove bound nucleic acid detection systems, thereby allowing the same detection systems to be used again to detect different target nucleic acids and to provide for higher levels of multiplexing.
Li-chong Wang, Han Lu, Bingqing Zhang, Li Wang, Hailing Zong, Xiao-Jun Ma
Filed: 20 Nov 20
Utility
IL-37 fusion protein and methods of making and using same
13 Dec 22
The disclosure provides interleukin 37 (IL-37) fusion proteins, methods of making IL-37 fusion proteins including constructs used to express IL-37 fusion proteins, and methods of using IL-37 fusion proteins.
Vassilios Kalabokis, Charles A. Dinarello
Filed: 20 Mar 18
Utility
Methods and Compositions for Delivering Compact Lyophilized Agents for Dissolving In a Closed System
3 Nov 22
The invention relates to packaged lyophilized agents.
Timothy John Manning, JR., Joy Lynn Aho, Todd Geders, Sean Henry Kevlahan, Garrett Michael Morris, Charles D. Brawley
Filed: 9 Sep 20
Utility
Detection of Double Stranded Nucleic Acids In Situ and Methods Related Thereto
9 Jun 22
The invention provides methods for detecting target double stranded nucleic acids, including for in situ hybridization assays.
Xiao-Jun MA, Farzaneh TONDNEVIS, Courtney TODOROV, Bingqing ZHANG
Filed: 11 Mar 20
Utility
Surface Plasmon Resonance Sensor Chip Having Sensor Surface Capable of Capturing Multiple Species of Antibodies and Method of Making
2 Jun 22
A surface plasmon resonance chip includes a sensor surface having a substrate, an inert metal layer directly on the substrate, a surface layer directly on the inert metal layer, and fusion proteins immobilized on the surface layer.
Robyn Ann Stoller
Filed: 17 Feb 22
Utility
Methods for Digital Multiplexing of Nucleic Acids In Situ
21 Apr 22
The invention relates to methods of multiplex detection of a plurality of target nucleic acids using combinations of labels by contacting a sample comprising a cell comprising a plurality of target nucleic acids with a set of probes, wherein the set of probes comprises subsets of probes comprising a plurality detectable labels that provide unique labeling of each target nucleic acid, wherein each probe subset comprises one or more distinct labels, wherein the number and/or combination of distinct labels is unique for each target nucleic acid; and detecting the detectable labels bound to the respective target nucleic acids.
Xiao-Jun MA, Emily PARK, Shiping CHEN
Filed: 31 Oct 19
Utility
In Situ Detection of Nucleotide Variants In High Noise Samples, and Compositions and Methods Related Thereto
23 Dec 21
The invention relates to methods of in situ detection of a nucleic acid variation of a target nucleic acid in a sample, including single nucleotide variations, multi-nucleotide variations or splice sites.
Yuling Luo, Xingyong Wu, Liuliu Pan, Xiaoming Wang, Xiao-Jun Ma, Nan Su, Steve Chen
Filed: 29 Jun 21
Utility
WNT/SFRP Complexes, Wnt-containing Compositions, Wnt-expressing Cells, and Methods of Making, Purifying, and Using Same
9 Dec 21
This disclosure describes isolated protein complexes including a Wnt and a sFRP; compositions including a Wnt; a cell overexpressing a Wnt and a sFRP; compositions including a cell overexpressing a Wnt and a cell overexpressing a sFRP; methods of making the protein complexes, compositions, and cells; and methods of using the isolated protein complexes, compositions, and cells.
Anthony Person, Liwen Xiong, Ming Bi, Camrin Tracy
Filed: 18 Jun 21
Utility
Methods for non-invasive profiling of stem cell differentiation
31 Aug 21
A method for characterizing stem cell differentiation includes harvesting differentiation media supernatant containing secreted analytes from key time points during a stem cell differentiation, performing at least one of a qualitative and a quantitative analysis of the differentiation media supernatant with respect to at least one secreted analyte, and identifying trends in analyte expression based on at least one of the qualitative and quantitative analysis of the differentiation media supernatant.
Richard Karl Fuerstenberg, Joy Lynn Aho, Fabrizio Rinaldi
Filed: 14 Jun 17