57 patents
Utility
Methods of preparing cell-binding agent-drug conjugates
5 Dec 23
The present invention provides methods of preparing a cell-binding agent-cytotoxic agent conjugate comprising a cell-binding agent (CysCBA) having one or more unpaired cysteine residues covalently linked to a cytotoxic agent.
Scott A Hilderbrand, Daniel F. Milano
Filed: 20 Mar 20
Utility
Biparatopic FR-alpha antibodies and immunoconjugates
5 Dec 23
The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies.
Olga Ab, Neeraj Kohli, Thomas Chittenden, Julianto Setiady
Filed: 10 Jun 22
Utility
Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders
24 Oct 23
Michael Louis Miller, Manami Shizuka, Ravi V. J. Chari
Filed: 27 Dec 18
Utility
Process for preparing substituted indolines
19 Sep 23
Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
Filed: 26 Feb 21
Utility
Preparation of maytansinoid antibody conjugates by a one-step process
5 Sep 23
The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products.
Xinfang Li, Jared M. Worful
Filed: 9 Jul 21
Utility
Conjugates comprising cell-binding agents and cytotoxic agents
22 Aug 23
The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA.
Nathan Elliott Fishkin, Daniel J. Tavares, Lingyun Rui, Luke B. Harris, Manami Shizuka, Michael Louis Miller, Ravi V. J. Chari
Filed: 12 Feb 21
Utility
Therapeutic combinations comprising anti-CD123 immunoconjugates
18 Jul 23
Therapeutic combinations of immunoconjugates that bind to CD123 (e.g., IMGN632) with BCL-2 inhibitors (e.g., venetoclax), and/or a hypomethylating agent (e.g., azacitidine or decitabine) are provided.
Sharlene Adams, Callum M. Sloss, Patrick Zweidler-McKay
Filed: 29 Apr 20
Utility
Methods of preparing cytotoxic benzodiazepine derivatives
28 Feb 23
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Michael Reardon, Richard A. Silva
Filed: 7 Jan 21
Utility
Selective sulfonation of benzodiazepine derivatives
7 Feb 23
The invention relates to novel methods of preparing cell-binding agent-cytotoxic agent conjugates, wherein the cytotoxic agent is an imine-containing cytotoxic agent bearing a maleimide group.
Scott A. Hilderbrand, Benjamin M. Hutchins
Filed: 17 Sep 20
Utility
Benzodiazepine derivatives
22 Nov 22
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic.
Wei Li, Nathan Elliott Fishkin, Robert Yongxin Zhao, Michael Louis Miller, Ravi V. J. Chari
Filed: 7 Jan 21
Utility
Methods for preparing a purified maytansinoid conjugate in a solution
15 Nov 22
This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent.
Brenda A. Kellogg, Rajeeva Singh, Ravi V. Chari
Filed: 24 Sep 20
Utility
Process for preparing purified drug conjugates
18 Oct 22
The invention provides a process for preparing a cell-binding agent chemically coupled to a drug.
Yong Dai, Yong Wang, Shengjin Jin, Deborah H. Meshulam, Godfrey W. Amphlett
Filed: 27 Apr 18
Utility
Methods of preparing cytotoxic benzodiazepine derivatives
23 Aug 22
The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
Filed: 12 Aug 20
Utility
Methods of preparing cytotoxic benzodiazepine derivatives
26 Jul 22
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Michael Reardon, Richard A. Silva
Filed: 1 Oct 20
Utility
Biparatopic FR-α antibodies and immunoconjugates
26 Jul 22
The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies.
Olga Ab, Neeraj Kohli, Thomas Chittenden, Julianto Setiady
Filed: 28 Apr 20
Utility
Methods of preparing cytotoxic benzodiazepine derivatives
19 Jul 22
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
Filed: 22 Oct 20
Utility
Anti-CD123 antibodies and conjugates and derivatives thereof
17 May 22
The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα).
Yelena Kovtun, Daniel J. Tavares, Lingyun Rui, Thomas Chittenden
Filed: 22 Oct 20
Utility
Pharmaceutical formulations and methods of use thereof
22 Mar 22
This disclosure is directed to antibody-drug conjugates.
Elizabeth Bartlett
Filed: 12 Nov 19
Utility
Methods for antibody drug conjugation, purification, and formulation
15 Mar 22
Methods of producing, purifying, and formulating antibody drug conjugates (ADCs) are provided herein.
Daniel F. Milano, Michael R. Reardon, Richard A. Silva, Benjamin M. Hutchins, Robert W. Herbst
Filed: 11 Jan 19
Utility
Camptothecin derivatives
25 Jan 22
Disclosed herein are novel cytotoxic compounds, and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents.
Ravi V. J. Chari, Wayne C. Widdison, Wei Li, David P. Pleynet
Filed: 25 Sep 20