1391 patents
Utility
Non-human Animals Comprising a Humanized Coagulation Factor 12 Locus
18 Jan 24
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized coagulation factor XII (F12) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided.
Yajun Tang, Dan Chalothorn, Lyndon Mitnaul, Lori Morton, Daria Zamolodchikov, Nicole Alessandri-Haber, Lynn MACDONALD
Filed: 5 Jul 23
Utility
Cho Integration Sites and Uses Thereof
18 Jan 24
Expression-enhancing nucleotide sequences for eukaryotic expressions systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells.
Ying Shen, Darya Burakov, Gang Chen, James P. Fandl
Filed: 6 Sep 23
Utility
Taurine Supplemented Cell Culture Medium and Methods of Use
18 Jan 24
The specification describes a composition comprising an improved eukaryotic cell culture medium, which can be used for the production of a protein of interest.
Amy S. Johnson, Meghan E. Casey, Shadia Oshodi, Shawn Lawrence
Filed: 22 Sep 23
Utility
Methods for Characterizing Protein Complexes
18 Jan 24
Methods for characterizing protein complexes formed between protein drug products and soluble ligands are provided herein.
Nina Liu, Michael Rosconi, Erica Pyles
Filed: 6 Jul 23
Utility
Support for Test Device
11 Jan 24
A support holder for a test device is disclosed, wherein the holder may include a base having a first plurality of sidewalls having a first length and a second plurality of sidewalls having a second length, wherein the second length is greater than the first length, wherein the plurality of sidewalls define a cavity in the base, the cavity including a surface for receiving a portion of the test device; and a plurality of projections extending away from the base, wherein each projection of the plurality of projections is configured to be associated with a leg portion, and wherein a first sidewall of the first plurality of sidewalls includes a center notch positioned between a first corner portion and a second corner portion, and wherein a second sidewall of the first plurality of sidewalls includes a removable portion configured to cover an opening into an interior of the base.
Christopher HUNTER, Steven DAVIS, Melissa SHER, David VANHOUTE
Filed: 22 Sep 23
Utility
Manufacturing Process for High Titer Antibody
11 Jan 24
The present invention pertains to methods for manufacturing high titer antibody products.
John Mattila, Xiaolin Tang, Hanne Bak, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Michelle LaFond, Andrew Tustian, Philip Mellors, John Hourihan, John Crowley, Laura Callinan, Shadia Abike Oshodi, Ashley Witmer, Daniel Corbett, James Reilly, Ankit Vartak, Mark Chiboroski, Alessandra Starling, Robert Stairs, Hai-Yuan Goh, Liam Nicholl, Aishling Conlon
Filed: 28 Feb 23
Utility
Rotatable surgical table
9 Jan 24
Provided is a rotatable surgical apparatus and accompanying method for processing a specimen via the rotatable surgical apparatus.
John Strein, Sam Cichon
Filed: 23 Jul 20
Utility
Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (ANGPTL7) inhibitors
9 Jan 24
The present disclosure provides methods of treating subjects having inflammation with an Angiopoietin-Like 7 (ANGPTL7) inhibitor and a glucocorticoid, methods of decreasing glucocorticoid-induced ophthalmic conditions in subjects, and methods of identifying subjects having an increased risk of developing glucocorticoid-induced ophthalmic conditions.
Gaurang Patel, Ying Hu, Kavita Praveen, Giovanni Coppola, Goncalo Abecasis, Aris Baras, Carmelo Romano
Filed: 23 Feb 22
Utility
Anti-FGFR2 antibodies and methods of use thereof
9 Jan 24
Provided herein are monoclonal antibodies, and antigen-binding fragments thereof, that bind fibroblast growth factor receptor 2 (FGFR2), and methods of use thereof and methods of use thereof.
Christopher Daly, Frank Delfino, Amy Han, Thomas Nittoli, Li Zhang
Filed: 21 Oct 21
Utility
Methods for treating inflammatory conditions of the airway or lungs by administering antagonist monoclonal antibodies to interleukin-33 and interleukin-4 receptor
9 Jan 24
The present invention provides methods for treating inflammatory diseases, or conditions associated with, or resulting in part from, elevated levels of IL-33 and IL-4, in particular inflammatory lung disorders.
Jamie M. Orengo, Jeanne Allinne, Andrew J. Murphy, George D. Yancopoulos
Filed: 22 Sep 20
Utility
Cas-ready mouse embryonic stem cells and mice and uses thereof
9 Jan 24
Methods and compositions are provided herein for assessing CRISPR/Cas-mediated non-homologous end joining (NHEJ) activity and/or CRISPR/Cas-induced recombination of a target genomic locus with an exogenous donor nucleic acid in vivo and ex vivo.
Guochun Gong, Charleen Hunt, Daisuke Kajimura, Suzanne Hartford, Brian Zambrowicz
Filed: 24 Aug 21
Utility
Methods for Selecting Patients for Treatment with an NGF Antagonist
4 Jan 24
Methods and compositions for treating pain associated with osteoarthritis of the knee and/or hip are disclosed.
Stephen DIMARTINO
Filed: 26 Apr 23
Utility
Medical Device Packaging and Related Methods
28 Dec 23
According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe.
Andrew COOK, Victor BRADFORD
Filed: 13 Sep 23
Utility
Non-human Animals Having a Humanized CLEC9A Gene
28 Dec 23
Disclosed herein is a genetically modified rodent animal comprising a humanized Clec9a gene in its genome.
Sokol Haxhinasto, Roberto Donnianni
Filed: 26 Jun 23
Utility
Methods for Quantitating Individual Antibodies from a Mixture
28 Dec 23
The present disclosure relates to, inter alia, a method of quantitating an amount of an antibody molecule from a mixture comprising two or more antibody molecules, comprising separating each of the two or more antibody molecules from the mixture by hydrophobic interaction chromatography high performance liquid chromatography (HIC-HPLC) and quantitating an amount of each antibody molecule, wherein the molecular weight of each antibody molecule is within 15 kDa of any other antibody molecule in the mixture and either each antibody molecule is different from another antibody molecule in the mixture by more than about 0.25 unit on the Kyte & Doolittle hydropathy scale or each of the antibody molecules when nm alone on HIC-HPLC elutes at distinct run time with little overlap from the other antibody molecules in the mixture, or both.
Dingjiang LIU, Lin LUO, Long XU
Filed: 30 Aug 23
Utility
Sustained Release Formulations Using Non-aqueous Emulsions
28 Dec 23
Non-aqueous emulsion methods for producing polymeric or polymer-coated microparticles are provided.
Yiming Zhao, Hunter Chen
Filed: 28 Jun 23
Utility
Crispr/cas Dropout Screening Platform to Reveal Genetic Vulnerabilities Associated with Tau Aggregation
28 Dec 23
Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic vulnerability associated with tau aggregation are provided.
Marine Prissette, Matthew Koss, Yu Bai, Brian Zambrowicz
Filed: 31 Aug 23
Utility
Tubulysins and Protein-tubulysin Conjugates
28 Dec 23
Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.
Amy HAN
Filed: 23 Dec 22
Utility
Methods Of Identifying And Evaluating Cat Allergy Gene Signatures In A Subject By Determining A Stratified Score Based On Gene Expression
28 Dec 23
The present disclosure provides methods of identifying a subject as suitable for the treatment or prevention of asthma exacerbation induced by a cat allergen with at least one antibody to the cat allergen.
Matthew F. Wipperman, Kaitlyn Gayvert, Wei Keat Lim, Jennifer D. Hamilton, Sara C. Hamon, Meagan O'Brien
Filed: 22 Jun 23
Utility
Anti-met Antibodies, Bispecific Antigen Binding Molecules That Bind Met, and Methods of Use Thereof
28 Dec 23
Provided herein are antibodies and bispecific antigen-binding molecules that bind MET and methods of use thereof.
Robert Babb, Gang Chen, Christopher Daly, John DaSilva, Douglas MacDonald, Thomas Nittoli
Filed: 25 May 23