10 patents
Utility
Molecules with Altered Neonate FC Receptor Binding Having Enhanced Therapeutic and Diagnostic Properties
4 Mar 20
The present invention provides molecules, including proteins, more particularly, immunoglobulins whose in vivo half-lives are altered (increased or decreased) by the presence of an IgG constant domain, or FcRn binding fragment thereof (e.g., an Fc region or hinge-Fc region) (e.g., from a human IgG, e.g., human IgG1), that have modifications of one or more of amino acid residues in at least the CH3 domain.
PING TSUI, MARTIN BORROK, WILLIAM DALL'ACQUA, YANLI WU, NURTEN BEYAZ-KAVUNCU
Filed: 9 Sep 19
Utility
Combination of an ANTI-VEGFR-2 Antibody and an ANTI-PD-L1 Antibody for the Treatment of Cancer
26 Feb 20
The present disclosure relates to a combination of anti-human VEGFR-2 antibodies (Ramucirumab) and anti-human PD-L1 (durvalumab) antibodies for treating certain disorders, including advanced gastric or gastroesophageal junction adenocarcinomas, non-small cell lung cancer, and hepatocellular carcinomas.
Richard Brian GAYNOR, Maria KARASARIDES
Filed: 26 Oct 17
Utility
ANTIBODY DIRECTED AGAINST S. AUREUS CLUMPING FACTOR A (ClfA)
12 Feb 20
The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody.
CHRISTINE TKACZYK, BRET SELLMAN, MARTIN BORROK, III, DAVIDE CORTI, ANDREA MINOLA
Filed: 23 Jul 19
Utility
Compositions Comprising Coformulation of ANTI-PD-L1 and ANTI-CTLA-4 Antibodies
18 Dec 19
Provided herein are compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making and using such compositions.
JIALI DU, AMBARISH SHAH
Filed: 27 Aug 19
Utility
Immune Repertoire Mining
4 Dec 19
The present invention provides a method for producing encapsulated natively-paired scFv amplicons, by encapsulating single cells in droplets, wherein the droplets further contain reagents for amplifying and sinking native pairings of heavy and light chain variable domain amplicons from single encapsulated cells; lysing the single encapsulated cells; and generating the encapsulated natively-paired scFv amplicons, wherein each scFv amplicon comprises a native pairing of heavy and light chain variable domain amplicons.
PARTHA S. CHOWDHURY, SARAVANAN RAJAN, MICHAEL ROBERT KIERNY
Filed: 11 Apr 17
Utility
Binding Molecules Specific For ASCT2 And Uses Thereof
4 Dec 19
This disclosure provides ASCT2-binding molecules, e.g., anti-ASCT2 antibodies, and antigen-binding fragments thereof, used in methods related to cancer stem cells, e.g., binding to a cancer stem cell.
Nabendu Pore, Martin J. Borrok III, Partha S. Chowdhury, Emil F. Michelotti, David A. Tice, Robert E. Hollingsworth, Chien-Ying Chang, Elaine M. Hunt, Nai Shun Yao
Filed: 7 Nov 17
Utility
ANTI-PD-L1 Antibody Treatment of Bladder Cancer
27 Nov 19
Provided are methods of treating bladder cancer (e.g., urothelial carcinoma, UC) in a subject having bladder cancer, e.g., UC, with an effective dose regimen of an anti-PD-L1 antibody, e.g., durvalumab, or an antigen binding fragment thereof.
JOHN KURLAND, JOHN ANDREW BLAKE-HASKINS, MAGDALENA ZAJAC, MARLON REBELATTO, ASHOK GUPTA, TONY HO, JILL WALKER, XIAOPING JIN, SHANNON MORRIS, ROBERT IANNONE, LI SHI, MOHAMMED DAR, YONG BEN
Filed: 15 Feb 18
Utility
Relaxin Fusion Polypeptides and Uses Thereof
20 Nov 19
The present invention relates to Relaxin fusion polypeptides, in particular to Relaxin 2 fusion polypeptides and uses thereof.
Weidong HAO, Andrew GARCIA, Changshou GAO, Isabelle SERMADIRAS
Filed: 23 Jan 18
Utility
Assay to Detect Human DPP-4
20 Nov 19
This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of DPP-4 levels in samples obtained from human patients.
Chien-Ying CHANG, Xiaodong XIAO, Partha CHOWDHURY
Filed: 5 Jun 19
Utility
Embedded Multiple-part Sensor Within a Plunger Rod to Capture and Transit Injection Information
13 Nov 19
A smart plunger rod adapted to push a medication out of a syringe is disclosed.
JARARDHANAN ANAND SUBRAMONY, MICHAEL C. SONG
Filed: 12 Dec 17
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