67 patents
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Utility
Human Anti-tau Antibodies
19 Aug 20
Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto.
Paul H. Weinreb, Feng Chen, Ellen A. Garber Stark, Jan Grimm, Fabio Montrasio
Filed: 23 Sep 19
Utility
Novel Salts
12 Aug 20
The invention relates to novel salts of 7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one, to compositions containing said salts and to the use of said salts in treating diseases and conditions mediated by modulation of voltage-gated sodium channels.
Gerard M. Giblin, David T. MacPherson, Michael Williams, David R. Witty, Julian Northen, Kalyan Vasudevan
Filed: 27 Sep 18
Utility
Human anti-alpha-synuclein antibodies
6 Jul 20
Provided are novel human α-synuclein-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto.
Andreas Weihofen, Jan Grimm, Roger Nitsch, Christoph Hock
Filed: 8 Jan 18
Utility
Liquid formulations of compounds active at sulfonylurea receptors
22 Jun 20
The invention provides liquid formulations of compounds that act at sulfonylurea receptors that are suitable for intravenous and intra-arterial infusion.
Sven Jacobson, Gillian Clarke, Rajinder Matharu
Filed: 7 Apr 16
Utility
Method for treating joint damage
18 May 20
Methods of treating joint damage in a subject eligible for treatment are provided involving administering an antagonist that binds to a B-cell surface marker, such as CD20 antibody, to the subject in an amount effective to slow progression of the joint damage as measured by radiography.
Mark Totoritis, Timothy Mark Shaw, Sunil Agarwal, David Yocum, Ariella Kelman
Filed: 29 Jul 19
Utility
Nuclear transport modulators and uses thereof
13 Apr 20
Vincent P. Sandanayaka, Sharon Shechter, Sharon Shacham, Dilara McCauley, Erkan Baloglu
Filed: 16 Jul 18
Utility
Pyrimidinyl tyrosine kinase inhibitors
13 Apr 20
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
Brian T. Hopkins, Timothy R. Chan, Tracy J. Jenkins, Patrick Conlon, Xiongwei Cai, Michael Humora, Xianglin Shi, Ross A. Miller, Andrew Thompson
Filed: 4 Mar 18
Utility
Tricyclic Compounds As Glycogen Synthase Kinase 3 (GSK3) Inhibitors and Uses Thereof
8 Apr 20
Florence Fevrier Wagner, Michel Weiwer, Arthur J. Campbell, Joshua R. Sacher, Edward Holson, Brian Stuart Lucas, TeYu Chen
Filed: 4 Apr 18
Utility
Anti-gpiib/iiia Antibodies or Uses Thereof
1 Apr 20
The present invention provides antibodies and antigen-binding molecules thereof which specifically bind the α and/or β subunits of the non-active form of the GPIIb/IIIIa receptor.
Joe Salas, Siyuan Tan, Robert Peters
Filed: 11 Jun 19
Utility
Formulations and Methods for Lyophilization and Lyophilates Provided Thereby
25 Mar 20
The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds.
Sven Martin Jacobson
Filed: 26 Sep 19
Utility
Composition Containing Glibenclamide
25 Mar 20
NSC antagonists are disclosed as useful in the treatment of dementia, in delaying the onset of dementia, and in the prevention of dementia.
Sven Martin JACOBSON, Robert ANG
Filed: 10 Oct 19
Utility
Methods of Modulating Immune Responses Using Bcma Polypeptide
25 Mar 20
A novel receptor in the TNF family is provided: BAFF-R.
Jeffrey Browning, Christine Ambrose, Fabienne MacKay, Jurg Tschopp, Pascal Schneider, Jeffrey Thompson
Filed: 15 Oct 19
Utility
ANTI-VLA-4 Related Assays
18 Mar 20
Methods and apparatus for assaying the level of analytes in a sample, related to VLA-4, are disclosed.
Tatiana Plavina, Paula S. Hochman, Michaela Lerner
Filed: 23 May 19
Utility
FC receptor (FcRn) binding peptides and uses thereof
16 Mar 20
The invention provided herein includes isolated polypeptides that specifically block the interaction between neonatal Fc receptor (FcRn) and albumin.
Richard S. Blumberg, Timo Rath, Kristi Baker, Adam Mezo, Zachary Taylor, Kevin McDonnell, Rosa Maria Silva Garcia Grenha
Filed: 5 Mar 19
Utility
Methods of preventing and removing trisulfide bonds
16 Mar 20
The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies.
Rashmi Rohit Kshirsagar, Alan Gilbert
Filed: 15 Oct 17
Utility
IRAK4 inhibiting agents
2 Mar 20
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
Timothy Chan, Kevin Guckian, Tracy Jenkins, Jermaine Thomas, Jeffery Vessels, Gnanasambandam Kumaravel, Robert Meissner, Joseph Lyssikatos, Brian Lucas, Irina Leaf, Jeremy Duffield
Filed: 7 Feb 19
Utility
Bruton's tyrosine kinase inhibitors
2 Mar 20
The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Minna Bui, Patrick Conlon, Julio H. Cuervo, Daniel A. Erlanson, Junfa Fan, Bing Guan, Brian T. Hopkins, Tracy J. Jenkins, Gnanasambandam Kumaravel, Alexey A. Lugovskoy, Doug Marcotte, Noel Powell, Daniel Scott, Laura Silvian, Art Taveras, Deping Wang, Min Zhong
Filed: 6 Sep 17
Utility
Anti-tnf-alpha Polypeptide Composition and Use Thereof
26 Feb 20
The invention provides a composition comprising an anti-tumor necrosis factor (TNF)-alpha polypeptide, wherein the composition produces a reduced level of immunogenicity when administered to a subject, as well as a treatment method involving the administration of the composition.
Jeehoon GHIL, Yoonseok LEE, Songyoung KIM, Orlando A. JAQUEZ, Robert S. GRONKE
Filed: 30 Oct 19
Utility
Novel Crystalline Forms
26 Feb 20
The present invention is directed to novel crystalline forms of 5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.
Nishanth Gopinathan, Erwin Irdam, William Kiesman, Daw-long A. Kwok, Yiqing Lin, Frederick Osei-Yeboah, Matthew Peterson, Kenny Tran, Kalyan Vasudevan
Filed: 17 May 18
Utility
Apparatus and Related Method to Facilitate Test Via a Computing Device
26 Feb 20
This disclosure relates to a device to mechanically and electrically connect with a touch screen computing device, such as a tablet computer.
Jay L. Alberts, David D. Schindler, Jane Rhodes, Wendy Gabel, Jim Best
Filed: 22 Sep 19