93 patents
Utility
RNAi Agents for Inhibiting Expression of DUX4, Compositions Thereof, And Methods of Use
28 Dec 23
Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a double homeobox 4 (DUX4) gene.
Zhi-Ming Ding, Jonathan Van Dyke, Xiaokai Li, Anthony Nicholas, Casi M. Schienebeck, Tao Pei, Zhao Xu, Teng Ai, Susan Phan, Susan Ramos-Hunter
Filed: 9 Mar 23
Utility
Integrin Targeting Ligands and Uses Thereof
21 Dec 23
Xiaokai Li, Tao Pei, Susan Phan, Andrei V. Blokhin
Filed: 9 Mar 23
Utility
RNAi agents for inhibiting expression of DUX4, compositions thereof, and methods of use
19 Dec 23
Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a double homeobox 4 (DUX4) gene.
Zhi-Ming Ding, Jonathan Van Dyke, Xiaokai Li, Anthony Nicholas, Casi M. Schienebeck, Tao Pei, Zhao Xu, Teng Ai, Susan Phan, Susan Ramos-Hunter
Filed: 9 Mar 23
Utility
Compositions and methods for inhibiting gene expression of Hif2alpha
12 Dec 23
RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2α (EPAS1) gene are described.
So Wong, David L. Lewis, David B. Rozema, Darren H. Wakefield, Steven B. Kanner, Weijun Cheng, Lauren J. Almeida, Andrei V. Blokhin, Jeffrey C. Carlson, Anthony L. Nicholas, Aaron Almeida, Jonathan D. Benson, Justin Woods
Filed: 19 Feb 21
Utility
Rnai Agents for Hepatitis B Virus Infection
9 Nov 23
Described are compositions and methods for inhibition of Hepatitis B virus gene expression.
Zhen LI, Rui ZHU, Christine I. WOODDELL, Bruce D. GIVEN, Tao PEI, David L. LEWIS, Lauren J. ALMEIDA, David B. ROZEMA, Darren H. WAKEFIELD
Filed: 2 Dec 22
Utility
Rnai Therapy for Hepatitis B Virus Infection
9 Nov 23
Described are compositions and methods for inhibition of Hepatitis B virus gene expression.
Christine I. WOODDELL, David B. Rozema, David L. Lewis, Darren H. Wakefield, Lauren J. Almeida
Filed: 21 Dec 22
Utility
Methods for the Reduction of Z-aat Protein Levels
2 Nov 23
Described are methods of reducing liver Z-AAT protein levels in a human subject with a PiZZ genotype of alpha-1 antitrypsin (AAT) by using pharmaceutical compositions that include AAT RNAi agents.
Dawn Christianson, James C. Hamilton, Bruce Given
Filed: 14 Sep 21
Utility
RNAi Agents And Compositions for Inhibiting Expression of Apolipoprotein C-III (APOC3)
12 Oct 23
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, capable of inhibiting Apolipoprotein C-III (also called APOC3, apoC-III, APOC-III, and APO C-III) gene expression, and compositions that include APOC3 RNAi agents.
Zhen Li, Rui Zhu, Tao Pei, Steven Kanner, So Wong
Filed: 22 Dec 22
Utility
Lipid Conjugates for the Delivery of Therapeutic Agents
20 Jul 23
Xiaokai Li, Tao Pei, Teng Ai, Susan Phan, Susan Ramos-Hunter
Filed: 3 Mar 23
Utility
RNAi Agents for Inhibiting Expression of Xanthine Dehydrogenase (XDH), Pharmaceutical Compositions Thereof, and Methods of Use
4 May 23
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression.
Anthony NICHOLAS, Tao PEI, Zhao XU, Daniel BRAAS, Zhi-Ming DING
Filed: 12 Oct 22
Utility
RNAi Agents for Inhibiting Expression of Xanthine Dehydrogenase (XDH), Pharmaceutical Compositions Thereof, and Methods of Use
27 Apr 23
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression.
Anthony NICHOLAS, Tao PEI, Zhao XU, Daniel BRAAS, Zhi-Ming DING
Filed: 28 Oct 22
Utility
RNAi agents for inhibiting expression of xanthine dehydrogenase (XDH), pharmaceutical compositions thereof, and methods of use
18 Apr 23
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression.
Anthony Nicholas, Tao Pei, Zhao Xu, Daniel Braas, Zhi-Ming Ding
Filed: 19 May 22
Utility
Integrin ligands and uses thereof
7 Mar 23
Zhen Li, Xiaokai Li, Erik W. Bush, Rui Zhu, Dongxu Shu, Jonathan Benson, Patrick Shao, Matthew Fowler-Watters
Filed: 31 Oct 18
Utility
RNAi agents for hepatitis B virus infection
28 Feb 23
Described are compositions and methods for inhibition of Hepatitis B virus gene expression.
Zhen Li, Rui Zhu, Christine I. Wooddell, Bruce D. Given, Tao Pei, David L. Lewis, Lauren J. Almeida, David B. Rozema, Darren H. Wakefield
Filed: 11 Aug 20
Utility
RNAi Agents for Inhibiting Expression of Beta-ENaC, Compositions Thereof, and Methods of Use
19 Jan 23
Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a beta-ENaC (SCNN1B) gene.
Anthony Nicholas, Casi M. Schienebeck, Erik W. Bush, Tao Pei, Zhao Xu, Zhen Li, Rui Zhu
Filed: 28 Apr 22
Utility
RNAi Agents for Inhibiting Expression of Xanthine Dehydrogenase (XDH), Pharmaceutical Compositions Thereof, and Methods of Use
19 Jan 23
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression.
Anthony NICHOLAS, Tao PEI, Zhao XU, Daniel BRAAS, Zhi-Ming DING
Filed: 19 May 22
Utility
RNAi agents for inhibiting expression of xanthine dehydrogenase (XDH), pharmaceutical compositions thereof, and methods of use
10 Jan 23
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression.
Anthony Nicholas, Tao Pei, Zhao Xu, Daniel Braas, Zhi-Ming Ding
Filed: 19 May 22
Utility
RNAi Agents for Inhibiting Expression of Mucin 5AC (MUC5AC), Compositions Thereof, and Methods of Use
5 Jan 23
Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Mucin 5AC (MUC5AC) gene.
Erik W. Bush, Anthony Nicholas, Casi M. Schienebeck
Filed: 25 May 22
Utility
Compositions and Methods for Inhibiting Gene Expression of ALPHA-1 Antitrypsin
5 Jan 23
The invention relates to a RNA interference triggers for inhibiting the expression of an AAT gene through the mechanism of RNA interference.
Christine I. Wooddell, David L. Lewis, Darren H. Wakefield, Lauren Almeida, Steven B. Kanner
Filed: 8 Jun 22
Utility
RNAi Agents for Inhibiting Expression of Xanthine Dehydrogenase (XDH), Pharmaceutical Compositions Thereof, and Methods of Use
5 Jan 23
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression.
Anthony NICHOLAS, Tao PEI, Zhao XU, Daniel BRAAS, Zhi-Ming DING
Filed: 19 May 22