502 patents
Page 3 of 26
Utility
Capsid Inhibitors for the Treatment of Hiv
5 Oct 23
The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions.
Chienhung Chou, Darryl Kato, Scott E. Lazerwith, John O. Link, Scott D. Schroeder, Winston C. Tse, Jennifer R. Zhang
Filed: 15 Feb 23
Utility
Antibodies and Fusion Proteins That Bind to CCR8 and Uses Thereof
5 Oct 23
Provided herein are various embodiments relating to antibodies and fusion proteins and uses thereof.
Lara Lewis MCGRATH, Fabien DÉPIS, Changyun HU, Leonard G. PRESTA, Joshua Adam BUGGÉ
Filed: 10 Mar 23
Utility
MCL-1 Inhibitors
5 Oct 23
The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
Hang Chu, Juan A. Guerrero, Anna E. Hurtley, Tae H. Hwang, Lan Jiang, Darryl Kato, Tetsuya Kobayashi, John E. Knox, Scott E. Lazerwith, Xiaofen Li, David W. Lin, Jonathan W. Medley, Michael L. Mitchell, Devan Naduthambi, Zachary Newby, Neil H. Squires, Vickie H. Tsui, Chandrasekar Venkataramani, William J. Watkins, Hong Yang
Filed: 9 Mar 23
Utility
Solid forms of a toll-like receptor modulator
3 Oct 23
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
Krista Marie Diaz, Patricia Andres, Valeriya N. Smolenskaya
Filed: 21 Jun 21
Utility
Phospholipid compounds and uses thereof
3 Oct 23
Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang
Filed: 23 Aug 21
Utility
Darunavir Combination Formulations
28 Sep 23
This invention relates to solid oral dosage forms of the HIV inhibitor Darunavir and/or a pharmaceutically acceptable salt or solvate thereof, and combination formulations thereof.
Urbain Alfons C. DELAET, Philip Erna H. HEYNS, Eugeen Maria Jozef JANS, Roel Jos M. MERTENS, Geert VAN DER AVOORT
Filed: 5 May 23
Utility
Prodrugs of Phosphonamide Nucleotide Analogues and Their Pharmaceutical Use
28 Sep 23
Compounds, compositions, and method useful for treating a viral infection, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, are disclosed.
Daniel H. Byun, Byoung-Kwon Chun, Michael O. Clarke, Petr Jansa, Devan Naduthambi, Neil H. Squires
Filed: 5 Aug 21
Utility
Antiviral compounds
26 Sep 23
The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
Gregory F. Chin, Byoung-Kwon Chun, Michael O. Clarke, Bindu Goyal, Hon C. Hui, Petr Jansa, Richard L. Mackman, Dustin S. Siegel, Hai Yang
Filed: 18 Feb 21
Utility
Compounds and Methods for Treatment of Viral Infections
21 Sep 23
Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
Mark J. Bartlett, Daniel H. Byun, Yifan Deng, Jennifer L. Cosman Ellis, Rao V. Kalla, Richard L. Mackman, Dustin S. Siegel, Xianhuang Zeng
Filed: 1 Mar 23
Utility
Antiviral Compounds
21 Sep 23
The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.
Daniel H. Byun, Gregory F. Chin, Byoung-kwon Chun, Michael O. Clarke, Bindu Goyal, Hon C. Hui, Petr Jansa, Richard L. Mackman, Michael R. Mish, Dustin S. Siegel, David Sperandio, Hai Yang, Lijun Zhang
Filed: 21 Feb 23
Utility
Ikaros Zinc Finger Family Degraders and Uses Thereof
21 Sep 23
The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos).
Gayatri Balan, Peter A. Blomgren, Chen Chen, Julian A. Codelli, Zhimin Du, Musong Kim, Dorothée Saddier Axe, Gregg M. Schwarzwalder, Rhiannon Thomas-Tran, Michael T. Tudesco, Chandrasekar Venkataramani, William J. Watkins, Brian M. Weist, Suet C. Yeung, Helen Yu
Filed: 7 Apr 23
Utility
Methods of Preparing 1`-CYANO Nucleosides
21 Sep 23
The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I).
Pavel R. Badalov, Stacy Bremner, Matthew R. Chin, Detian Gao, Nolan Griggs, Lars V. Heumann, Chiajen Lai, Robert R. Milburn, Sankar Mohan, Sean T. Neville, Bing Shi, Andrew C. Stevens, Nicholas A.J. Uhlig, Tiago Vieira, Todd A. Wenderski
Filed: 10 Feb 23
Utility
Processes and intermediates for preparing MCL1 inhibitors
19 Sep 23
The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
Filed: 22 Mar 22
Utility
Methods and intermediates for preparing therapeutic compounds
19 Sep 23
Sachin Dhar, Alex Goldberg, Lars V. Heumann, Zilin Huang, Vinh Xuan Ngo, Trevor James Rainey, Dietrich P. Steinhuebel, Xianghong Wang, Scott Alan Wolckenhauer
Filed: 16 Jun 21
Utility
Therapeutic compounds
12 Sep 23
Gediminas Brizgys, Eda Canales, Chienhung Chou, Michael Graupe, Jiayao Li, Roland D. Saito, Scott D. Schroeder, Winston C. Tse, Qiaoyin Wu, Jennifer R. Zhang
Filed: 26 Jan 22
Utility
Compounds and Methods for Treatment of Viral Infections
7 Sep 23
Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
Mark J. Bartlett, Daniel H. Byun, Yifan Deng, Jennifer L. Cosman Ellis, Rao V. Kalla, Richard L. Mackman, Dustin S. Siegel, Xianhuang Zeng
Filed: 6 Mar 23
Utility
Compounds and Methods for Treatment of Viral Infections
7 Sep 23
Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
Mark J. Bartlett, Daniel H. Byun, Yifan Deng, Jennifer L. Cosman Ellis, Rao V. Kalla, Richard L. Mackman, Dustin S. Siegel, Xianhuang Zeng
Filed: 6 Mar 23
Utility
Compounds and Methods for Treatment of Viral Infections
7 Sep 23
Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
Mark J. Bartlett, Daniel H. Byun, Yifan Deng, Jennifer L. Cosman Ellis, Rao V. Kalla, Richard L. Mackman, Dustin S. Siegel, Xianhuang Zeng
Filed: 6 Mar 23
Utility
Therapeutic compositions for treatment of human immunodeficiency virus
5 Sep 23
A solid oral dosage form is provided, comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.
Benjamin Micah Collman, Lei Hong, Joanna M. Koziara
Filed: 6 May 22
Utility
Substituted Pyrrolizine Compounds and Uses Thereof
31 Aug 23
This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
Jinfa Du, Joshua A. Kaplan, Thorsten A. Kirschberg, Tetsuya Kobayashi, Scott E. Lazerwith, Rick Andrew Lee, Jonathan William Medley, Michael L. Mitchell, Philip Anthony Morganelli, Hyung-Jung Pyun, Sophia L. Shevick, Neil H. Squires, William J. Watkins
Filed: 29 Nov 22