26 patents
Utility
Antiviral Prodrug Compounds
7 Dec 23
Provided herein are nucleotide prodrug compounds, their preparation and their uses, such as treating diseases or conditions of a viral infection.
Lin Zhi
Filed: 19 Oct 21
Utility
Benzyloxy Phosph(on)ate Compounds
25 May 23
Provided herein are 2-substituted benzyloxy phosph(on)ate compounds, their preparation and their uses, such as treating liver diseases or conditions.
Lin Zhi
Filed: 19 Apr 21
Utility
TRIAZOLO[4,5-D] Pyramidine Derivatives and Their Use As Purine Receptor Antagonists
30 Mar 23
Samantha Jane Bamford, Roger John Gillespie, Richard Simon Todd
Filed: 24 Aug 22
Utility
Apparatus and Methods for Laser-based Single Cell Recovery from Microcapillary Arrays
24 Nov 22
Systems and methods for recovering content of a sample from a microcapillary array are provided.
Bob CHEN, Austin BLANCO, Ryan Lewis KELLY, Frances LIU, Derek CROOTE, Samuel Timothy HATCH
Filed: 6 Nov 20
Utility
Nucleotide Prodrug Compounds
22 Sep 22
Provided herein are nucleotide prodrug compounds, their preparation and their uses, such as treating diseases or conditions of a viral infection.
Lin Zhi
Filed: 8 Jun 22
Utility
Bcat Modulation
1 Sep 22
This disclosure relates to, in part, the treatment of an organic acidemia in a subject in need thereof via administration of a therapeutically effective amount of compounds that inhibit BCAT2.
Paul R. August, Margaret Kenney, Jacques Mauger, Mark Drew, Weixi Kong
Filed: 8 Jul 20
Utility
Cyclic Phosphate Compounds
14 Jul 22
Provided herein are cyclic phosphate compounds, their preparation and their uses, such as treating liver diseases or conditions or a disease or condition in which the physiological or pathogenic pathways involve the liver.
Lin Zhi
Filed: 21 Apr 20
Utility
Apj Modulators and Uses Thereof
14 Jul 22
Described herein are protein scaffolds comprising an apelin (APJ) receptor binding domain.
Roy Louis MAUTE, John S. BURG
Filed: 18 Jun 20
Utility
Crystalline Forms and Methods of Producing Crystalline Forms of a Compound
30 Jun 22
Disclosed herein are methods of crystallizing the compound of Formula (I), as well as crystalline forms thereof.
Lin Zhi, Henri Sasmor
Filed: 16 Apr 20
Utility
Methods and Systems for Screening Using Microcapillary Arrays
26 May 22
High-throughput methods for screening large populations of variant proteins are provided.
Vivian Hsieh, Bob Chen, Ryan Lewis Kelly
Filed: 6 Apr 20
Utility
Heterocycle Amines and Uses Thereof
21 Apr 22
Compounds and methods in the fields of chemistry and medicine are disclosed.
Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
Filed: 28 Oct 21
Utility
Multi-stage Sample Recovery System
10 Feb 22
Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided.
Bob Chen
Filed: 20 Oct 21
Utility
Compositions and Methods for Inhibiting Endogenous Immunoglobulin Genes and Producing Transgenic Human Idiotype Antibodies
19 Aug 21
The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same.
Roland BUELOW
Filed: 22 Dec 20
Utility
a Monoclonal Antibody Against Human 4-1BB, Method for Preparing the Same, and Use Thereof
29 Jul 21
Provided are novel fully human monoclonal antibodies that bind to human 4-1BB.
Yong ZHENG, Jingjing LIU, Jing LI
Filed: 10 Apr 19
Utility
Glucagon Receptor Antagonists
29 Apr 21
Provided herein are solid state forms of compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity.
Lin Zhi, Ian Henderson, Joseph Kaloko, Martin Osterhout
Filed: 13 Feb 19
Utility
Methods and Compositions Associated with the Granulocyte Colony-stimulating Factor Receptor
18 Feb 21
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR).
Lin Zhi, Keith Marschke, Virginia H. Grant, Steven L. Roach, Yixing Shen, Jason C. Pickens, Bijan Pedram, Cornelis Arjan van Oeveren, Lino J. Valdez, Andrew R. Hudson
Filed: 10 Jul 20
Utility
Imidazo-fused Heterocycles and Uses Thereof
11 Feb 21
Compounds and methods in the fields of chemistry and medicine are disclosed.
Lin Zhi
Filed: 15 Oct 20
Utility
Selective Androgen Receptor Modulators (Sarms) and Uses Thereof
18 Nov 20
Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors.
Lin Zhi
Filed: 2 Aug 20
Utility
Acetal Compounds and Therapeutic Uses Thereof
28 Oct 20
Disclosed herein are acetal and cyclic acetal compounds, compositions, their preparation, and their uses.
Lin Zhi
Filed: 7 Jan 19
Utility
Sirp Polypeptide Compositions and Methods of Use
26 Aug 20
Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.
Aaron Michael RING, Roy Louis MAUTE, Andrew Curtis KRUSE, Aashish MANGLIK, Kenneth S. LIN
Filed: 3 May 20