394 patents
Utility
Quinone Methide Analog Signal Amplification
18 Jan 24
Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample.
Christopher Bieniarz, Julia Ashworth-Sharpe, Brian D. Kelly, Nathan Polaske
Filed: 11 Aug 23
Utility
Line-based Image Registration and Cross-image Annotation Devices, Systems and Methods
11 Jan 24
The disclosure relates to devices, systems and methods for image registration and annotation.
Srinivas Chukka, Anindya Sarkar, Quan Yuan
Filed: 15 Sep 23
Utility
Stained Biological Specimens Including One or More Biomarkers Labeled with One or More Detectable Moieties
11 Jan 24
The present disclosure is directed to a method of staining a biological specimen (e.g. a single serial tissue section derived from a biological sample) with one or more routine and/or special statins while concomitantly labeling the same biological specimen with one or more detectable moieties without the need for stripping any stain or evaluating different images of stained serial tissue sections of a biological specimen.
Daniel R. Bauer, Mark Lefever, Larry Morrison
Filed: 20 Jul 23
Utility
Storage Stable Caged Haptens
4 Jan 24
Disclosed herein are caged haptens and caged hapten-antibody conjugates useful for facilitating the detection of targets located proximally to each other in a sample.
Yuri Belosludtsev, Brian D. Kelly, Nathan W. Polaske
Filed: 10 Jul 23
Utility
Gas Knife Using Parallelogram Flow
4 Jan 24
In one aspect of the present disclosure is a method of contactlessly urging, directly, or moving a substance on the surface of a substrate, the method employing a gas knife configured to produce a gas curtain having parallelogram flow.
Charles Hassen
Filed: 18 Sep 23
Utility
Application of click chemistry for signal amplification in IHC and ISH assays
2 Jan 24
Applicants have developed an amplification system and methodology for IHC and ISH staining that utilizes “click chemistry” to covalently bind reporter molecules to tissue.
Brian D. Kelly, Nathan W. Polaske
Filed: 28 Jan 22
Utility
Methods and Systems for Evaluation of Immune Cell Infiltrate In Tumor Samples
28 Dec 23
Immune context scores are calculated for tumor tissue samples using continuous scoring functions.
Michael Barnes, Joerg Bredno, Rebecca C. Bowermaster, Srinivas Chukka, Wen-Wei Liu, Kandavel Shanmugam, Junming Zhu
Filed: 29 Aug 23
Utility
Systems for cell shape estimation
12 Dec 23
According to various embodiments, a system and method for processing an image of a biological specimen stained for a presence of at least one lymphocyte biomarker is disclosed.
Joerg Bredno, Konstanty Korski, Oliver Grimm
Filed: 9 Oct 20
Utility
Quality metrics for automatic evaluation of dual ISH images
5 Dec 23
The present disclosure is directed to a computer system designed to (i) receive a series of images as input; (ii) compute a number of metrics derived from focus features and color separation features within the images; and (iii) evaluate the metrics to return (a) an identification of the most suitable z-layer in a z-stack, given a series of z-layer images in a z-stack; and/or (b) an identification of those image tiles that are more suitable for cellular based scoring by a medical professional, given a series of image tiles from an area of interest of a whole slide scan.
Jeffrey Atchison, Jim Martin, Anindya Sarkar
Filed: 22 Feb 21
Utility
Contextually Adaptive Digital Pathology Interface
30 Nov 23
A method, system, and computer program product for an image visualization system (120) that includes a contextually adaptive digital pathology interface.
Joao Ferreira, Alexander Kalogrides, Olivier Troy, Eduardo Ferroao Ulrich
Filed: 14 Aug 23
Utility
System Level Calibration
23 Nov 23
Disclosed herein are systems and methods of calibrating a microscope or an imaging system prior to acquiring image data of a sample.
Karl Garsha, Dustin Harshman
Filed: 4 Aug 23
Utility
Line-based image registration and cross-image annotation devices, systems and methods
21 Nov 23
The disclosure relates to devices, systems and methods for image registration and annotation.
Srinivas Chukka, Anindya Sarkar, Quan Yuan
Filed: 5 Mar 21
Utility
Automated high volume slide processing system
14 Nov 23
An automated system is provided for performing slide processing operations on slides bearing biological samples.
Kurt Reinhardt, Charles D. Lemme, Glen Ward, William L. Richards, Wayne Showalter, Brandon Ambler, Austin Micheil Ashby, Chris Borchert, Devon C. Campbell, Kimberly Christensen, Matthew Freeman, Andrew Ghusson, Rick Griebel, Kendall B. Hendrick, Miroslav Holubec, Parula Mehta, Vince Rizzo
Filed: 6 Jul 21
Utility
Foreground segmentation and nucleus ranking for scoring dual ISH images
7 Nov 23
The present disclosure describes a method of foreground segmentation and nucleus ranking for scoring dual ISH images.
Anindya Sarkar, Jim Martin
Filed: 21 Jul 22
Utility
Proximity assays using chemical ligation and hapten transfer
7 Nov 23
Methods for in situ detecting proximity of two targets of interest featuring an antibody conjugated with a cleavable bridge component having a detectable moiety and an antibody conjugated with a non-cleavable bridge component.
Christopher Bieniarz, Rui Hong
Filed: 4 Mar 20
Utility
Computational Pathology Approach for Retrospective Analysis of Tissue-based Companion Diagnostic Driven Clinical Trial Studies
2 Nov 23
Automated systems and methods are presented for retrospectively analyzing clinical trial data.
Michael BARNES, Christophe Chefd'hotel, Srinivas Chukka
Filed: 16 Jun 23
Utility
Contextually adaptive digital pathology interface
31 Oct 23
A method, system, and computer program product for an image visualization system (120) that includes a contextually adaptive digital pathology interface.
Joao Ferreira, Alexander Kalogrides, Olivier Troy, Eduardo Ferroao Ulrich
Filed: 14 Dec 22
Utility
Gas knife using parallelogram flow
24 Oct 23
In one aspect of the present disclosure is a method of contactlessly urging, directly, or moving a substance on the surface of a substrate, the method employing a gas knife (300) configured to produce a gas curtain having parallelogram flow.
Charles Hassen
Filed: 17 Oct 19
Utility
Single-stranded oligonucleotide probes for chromosome or gene copy enumeration
17 Oct 23
Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics.
Michael Farrell, Antony Hubbard, Donald Johnson, Brian Kelly, Taylor Shingler, Lei Tang, Wenjun Zhang
Filed: 20 May 20
Utility
Methods and systems for evaluation of immune cell infiltrate in tumor samples
10 Oct 23
Immune context scores are calculated for tumor tissue samples using continuous scoring functions.
Michael Barnes, Joerg Bredno, Rebecca C. Bowermaster, Srinivas Chukka, Wen-Wei Liu, Kandavel Shanmugam, Junming Zhu
Filed: 5 Jan 22