394 patents
Page 2 of 20
Utility
Quinone methide analog signal amplification
10 Oct 23
Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample.
Christopher Bieniarz, Julia Ashworth-Sharpe, Brian D. Kelly, Nathan Polaske
Filed: 7 Nov 18
Utility
Automatic Assay Assessment and Normalization for Image Processing
5 Oct 23
Disclosed herein are systems and methods for of assessing stain titer levels.
Yao Nie, Maria V. Sainz De Cea
Filed: 31 May 23
Utility
Hybrid and Accelerated Ground-truth Generation for Duplex Arrays
28 Sep 23
Methods and systems can include: accessing a digital pathology image; generating, using a first machine-learning model, a segmented image that identifies at least: a predicted diseased region and a background region in the digital pathology image; detecting depictions of a set of cells in the digital pathology image; generating, using a second machine-learning model, a cell classification for each cell of the set of cells, wherein the cell classification is selected from a set of potential classifications that indicate which, if any, of a set of biomarkers are expressed in the cell; detecting that a subset of the set of cells are within the background region; and updating the cell classification for each cell of at least some cells in the subset to be a background classification that was not included in the set of potential classifications.
Qinle Ba, Jim F. Martin, Satarupa Mukherjee, Yao Nie, Xiangxue Wang, Mohammadhassan Izady Yazdanabadi
Filed: 22 Mar 23
Utility
Opposables Incorporating Onboard Reagents and Automated Specimen Processing Systems
28 Sep 23
The present disclosure is directed to opposables including a body having a plurality of cavities disposed therein.
Christopher Lawrence Donat, Timothy James Keller
Filed: 18 May 23
Utility
Size-based separation of dissociated fixed tissues
26 Sep 23
The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.
Nelson Alexander, Aoune Barhoumi, Lisa Gallegos, Stacey Stanislaw
Filed: 16 Sep 19
Utility
Local tile-based registration and global placement for stitching
26 Sep 23
Techniques are provided for stitching tile images.
Jim Martin, Anindya Sarkar
Filed: 11 Oct 19
Utility
Convolutional neural networks for locating objects of interest in images of biological samples
12 Sep 23
Convolutional neural networks for detecting objects of interest within images of biological specimens are disclosed.
Srinivas Chukka, Jianxu Chen
Filed: 3 Feb 23
Utility
Prediction of Response to Epidermal Growth Factor Receptor-directed Therapies Using Epiregulin and Amphiregulin
7 Sep 23
Methods allowing prediction of a response to anti-EGFR therapies are provided, which include histochemical or cytochemical staining methods for staining amphiregulin (AREG) or epiregulin (EREG).
ISAAC YUYU BAI, JENNIFER HELEN BARRETT, FAYE ELLIOTT, WEN-WEI LIU, PHILIP QUIRKE, SUSAN DIANE RICHMAN, JENNIFER FRANCES SELIGMANN, MATTHEW THOMAS SEYMOUR, KANDAVEL SHANMUGAM, SHALINI SINGH, NICHOLAS PAUL WEST, CHRISTOPHER JAMES MICHAEL WILLIAMS, LIPING ZHANG
Filed: 20 Mar 23
Utility
System level calibration
5 Sep 23
Disclosed herein are systems and methods of calibrating a microscope or an imaging system prior to acquiring image data of a sample.
Karl Eric Garsha, Dustin Karl Harshman
Filed: 11 Nov 19
Utility
Materials and methods for performing histochemical assays for human pro-epiregulin and amphiregulin
5 Sep 23
The invention provides anti-human pro-epiregulin and anti-human amphiregulin antibodies and methods of using the same.
Fernando Jose Rebelo do Couto, Zhiming Liao, Andrea Muranyi, Kandavel Shanmugam, Shalini Singh, Yifei Zhu
Filed: 21 Oct 20
Utility
Systems and Methods for Staining of Biological Samples
17 Aug 23
A system and method for treatment of biological samples is disclosed.
Andreas Drechsler, Oliver Gutmann, Melis Hazar, Reto Huesser, Raymond T. Kozikowski, III, Daniel Mueller, Chris Steinert
Filed: 20 Apr 23
Utility
Methods, Systems, and Apparatuses for Quantitative Analysis of Heterogeneous Biomarker Distribution
17 Aug 23
Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein.
Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tothu Tania Vu, Brian J. Druker, Thomas Jacob
Filed: 26 Apr 23
Utility
Identifying Auto-fluorescent Artifacts In a Multiplexed Immunofluorescent Image
10 Aug 23
Embodiments disclosed herein generally relate to identifying auto-fluorescent artifacts in a multiplexed immunofluorescent image.
Auranuch LORSAKUL, Trung Kien NGUYEN, Yao NIE, Smadar SHIFFMAN, Xingwei WANG, Zuo ZHAO
Filed: 12 Apr 23
Utility
Deep Sequencing Profiling of Tumors
10 Aug 23
In one aspect of the present disclosure is a targeted sequencing workflow where an input sample comprising a sufficient quantity of genomic material is provided such minimal or no amplification cycles are utilized prior to sequencing.
Nelson R. Alexander, Daniel Burgess, Heidi J. Rosenbaum, Stacey Stanislaw
Filed: 6 Apr 23
Utility
Antibodies, compositions, and immunohistochemistry methods for detecting C4.4a
8 Aug 23
Antibodies, compositions, systems, and methods for detecting C4.4a, for example immunohistochemistry methods for detecting C4.4a using a C4.4a antibody.
Fernando Jose Rebelo do Couto, Zhiming Liao, Yifei Zhu
Filed: 5 Feb 21
Utility
Computational pathology approach for retrospective analysis of tissue-based companion diagnostic driven clinical trial studies
8 Aug 23
Automated systems and methods are presented for retrospectively analyzing clinical trial data.
Michael Barnes, Christophe Chefd'Hotel, Srinivas Chukka
Filed: 22 Jun 20
Utility
Diffusion Monitoring Protocol for Optimized Tissue Fixation
3 Aug 23
The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject.
Daniel Bauer, David Chafin, Michael Otter
Filed: 18 Mar 23
Utility
Automatic assay assessment and normalization for image processing
1 Aug 23
Disclosed herein are systems and methods for of assessing stain titer levels.
Yao Nie, Maria V. Sainz de Cea
Filed: 27 May 22
Utility
Correcting Differences In Multi-scanners for Digital Pathology Images Using Deep Learning
20 Jul 23
The present disclosure relates to techniques for transforming digital pathology images obtained by different slide scanners into a common format for image analysis.
Auranuch Lorsakul, Zuo Zhao, Yao Nie, Xingwei Wang, Kien Nguyen
Filed: 17 Feb 23
Utility
System and Method for Sample Preservation
6 Jul 23
A method is disclosed that permits calculation of reagent concentrations (in SI units) over time and space within a tissue sample as the sample is immersed in the reagent and the reagent diffuses into the tissue sample.
Daniel BAUER, David CHAFIN, Michael OTTER
Filed: 13 Mar 23