55 patents
Page 2 of 3
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Modified Beta-lactamases and Methods and Uses Related Thereto
24 Mar 22
Pertti KOSKI, Ulla AIRAKSINEN, Katja VALIMAKI
Filed: 23 Nov 21
Utility
Safe and effective beta-lactamase dosing for microbiome protection
22 Feb 22
The present invention relates to, inter alia, safe and effective doses of a beta-lactamase for, e.g. microbiome protection.
Joseph Sliman
Filed: 4 Jun 20
Utility
Beta-lactamases with improved properties for therapy
1 Feb 22
This invention relates to, in part, compositions of beta-lactamases and methods of using these enzymes in, for example, gastrointestinal tract (GI tract) disorders such as C. difficile infection (CDI).
Michael Kaleko, Sheila Connelly
Filed: 24 Jul 20
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Carbapenemases for Use with Antibiotics for the Protection of the Intestinal Microbiome
6 Jan 22
This invention relates, in part, to various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
Michael KALEKO, Sheila CONNELLY
Filed: 19 Aug 21
Utility
E. Coli-based Production of Beta-lactamase
28 Oct 21
The invention relates to, in part, improved methods for the production of beta-lactamase using Escherichia coli (E. coli) cells.
Andrew BRISTOL, Michael KALEKO, Steven HUBERT
Filed: 7 May 21
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Stabilized Pertussis Antibodies with Extended Half-life
28 Oct 21
The present invention relates, in part, to modified humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents.
Jennifer MAYNARD, Annalee NGUYEN, Michael KALEKO
Filed: 15 Aug 17
Utility
Alkaline Phosphatase Formulations
22 Jul 21
The present invention provides, in part, formulations comprising an alkaline phosphatase (AP)-based agent.
Vincent WACHER, J. Blair WEST, Michael KALEKO, Christian FURLAN FREGUIA
Filed: 29 Mar 21
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Microbiome Protection from Oral Antibiotics
22 Jul 21
This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption from orally administered antibiotics.
Michael KALEKO, Sheila CONNELLY
Filed: 28 Jun 17
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Methods of Making Alkaline Phosphatase Agents
24 Jun 21
The present invention relates to, inter alia, compositions and methods, including therapeutic alkaline phosphatases that find use in the treatment of disease, such as microbiome-related diseases.
Maria RODRIGUES, Veronique DE VAUX, Michael KALEKO
Filed: 17 Jun 19
Utility
Unknown
15 Jun 21
The invention relates to, in part, improved methods for the production of beta-lactamase using Escherichia coli (E. coli) cells.
Andrew Bristol, Michael Kaleko, Steven Hubert
Filed: 27 Aug 15
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Alkaline phosphatase formulations
27 Apr 21
The present invention provides, in part, formulations comprising an alkaline phosphatase (AP)-based agent.
Vincent Wacher, J. Blair West, Michael Kaleko, Christian Furlan Freguia
Filed: 17 Jul 18
Utility
Alkaline Phosphatase Agents for Treatment of Neurodevelopmental Disorders
4 Mar 21
The present invention relates, inter alia, to compositions and methods, including therapeutic alkaline phosphatases that find use in the treatment or prevention of various neurodevelopmental diseases or disorders.
Michael KALEKO, Christian FURLAN FREGUIA, Sheila CONNELLY
Filed: 8 Jan 19
Utility
Intestinal Alkaline Phosphatase Formulations
4 Feb 21
The present invention provides for a formulation comprising an active alkaline phosphatase (AP)-based agent and an enteric agent, wherein the formulation is suitable for releasing a substantial amount of the active AP-based agent in the intestines.
Andrew BRISTOL, Ray STAPLETON, Michael KALEKO, Christian FURLAN FREGUIA, Steven HUBERT, Cristina FREIRE, James GUBBINS
Filed: 20 Mar 19
Utility
Alkaline Phosphatase Agents for Treatment of Radiation Disorders
28 Jan 21
The present invention relates to, inter alia, compositions and methods, including therapeutic alkaline phosphatases that find use in the treatment or prevention of the effects of radiation exposure and/or chemotherapy.
Michael KALEKO, Christian FURLAN FREGUIA, Sheila CONNELLY
Filed: 20 Mar 19
Utility
Anti-methanogenic Lovastatin Analogs or Derivatives and Uses Thereof
21 Jan 21
The present invention relates to, in part, methods for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS) using at least one anti-methanogenic lovastatin analog or derivative.
Mark Pimentel, Vince Wacher
Filed: 29 Jun 20
Utility
Beta-lactamase Formulations and Uses Thereof
14 Jan 21
The present invention provides, in part, formulations comprising a beta-lactamase.
Andrew BRISTOL, Michael KALEKO, Sheila CONNELLY
Filed: 28 Sep 20
Utility
Clinically Efficacious Anti-methanogenic Compositions and Uses
16 Dec 20
The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS).
Vincent John Wacher, Mark Pimentel
Filed: 20 Jun 17
Utility
Method and Compositions for Inhibiting or Preventing Adverse Effects of Oral Antibiotics
9 Dec 20
This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
Michael KALEKO, Sheila CONNELLY, Vincent John WACHER
Filed: 19 Aug 20
Utility
Beta-lactamase formulations and uses thereof
9 Nov 20
The present invention provides, in part, formulations comprising a beta-lactamase.
Andrew Bristol, Michael Kaleko, Sheila Connelly
Filed: 23 Aug 18
Utility
Beta-lactamases with Improved Properties for Therapy
4 Nov 20
This invention relates to, in part, compositions of beta-lactamases and methods of using these enzymes in, for example, gastrointestinal tract (GI tract) disorders such as C. difficile infection (CDI).
Michael KALEKO, Sheila CONNELLY
Filed: 23 Jul 20