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Mannkind (MNKD)

Utility
Formation of N-protected 3,6-bis-(4-aminobutyl)-2,5-diketopiperazine through a cyclic α-N-protected amino ester
31 May 22
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided.
John J. Freeman, Otto Phanstiel, William Elliot Bay, Kelly Sullivan Kraft
Filed: 22 Dec 20
Utility
Inhalable dry powder pharmaceutical composition
19 Apr 22
A method for treating hyperglycemia and/or diabetes in a subject is provided.
Donald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
Filed: 19 Dec 19
Utility
Catalysis of diketopiperazine synthesis
5 Apr 22
Provided is a method for the synthesis of N-protected 3,6-bis-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ε-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
John J. Stevenson, Destardi Moye-Sherman
Filed: 24 Feb 20
Utility
Dry Powder Inhaler and System for Drug Delivery
17 Feb 22
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.
Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro
Filed: 27 Oct 21
Utility
Microcrystalline Diketopiperazine Compositions and Methods
17 Feb 22
Disclosed herein are DKP microcrystals made by an improved method where they do not irreversibly self-assemble into microparticles.
Bryan R. Wilson, Joseph J. Guarneri, Marshall L. Grant
Filed: 9 Sep 21
Utility
Dry powder inhaler and system for drug delivery
8 Feb 22
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.
Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro, Scott McLean, Dennis Overfield, Anthony Bryant
Filed: 8 Feb 19
Utility
Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them
27 Jan 22
The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of bedaquiline wherein the bedaquiline is provided in the form of a suspension, or in which the bedaquiline is provided in the form of a dry powder, and processes for their preparation.
Thomas Hofmann, Stefan Ufer, Kevin Stapleton
Filed: 9 Dec 19
Utility
Prodrugs of Treprostinil
9 Dec 21
Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
Hitesh BATRA, Liang GUO, Patrick POISSON, Sri Harsha TUMMALA, Elizabeth Ann HARRIS
Filed: 8 Jun 21
Utility
Microcrystalline diketopiperazine compositions and methods
7 Dec 21
Disclosed herein are DKP microcrystals made by an improved method where they do not irreversibly self-assemble into microparticles.
Bryan R. Wilson, Joseph J. Guarneri, Marshall L. Grant
Filed: 9 Jul 20
Utility
Dry powder inhaler and system for drug delivery
30 Nov 21
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.
Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro
Filed: 16 Apr 18
Utility
Composition and Method for Reducing Hypoglycemia Events In Diabetes Treatment
25 Nov 21
An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose.
Marshall Grant, Simon R. Bruce, Robert A. Baughman
Filed: 3 Aug 21
Utility
Apparatus, System and Method for Detecting and Monitoring Inhalations
25 Nov 21
Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system.
John J. Pocreva, III, Benoit Adamo, Brendan Laurenzi, Chad C Smutney, P. Spencer Kinsey
Filed: 24 Apr 19
Utility
Reactor for Producing Pharmaceutical Particles In a Precipitation Process
25 Nov 21
Reactors, reactor systems and methods for producing particles in a precipitation process are provided.
Sanket Gandhi, Karen Moraleda, Jadwiga Jachowicz, Michael Zupon
Filed: 3 Aug 21
Utility
Method of Drug Formulation Based on Increasing the Affinity of Active Agents for Crystalline Microparticle Surfaces
18 Nov 21
Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.
Mark Hokenson, Keith A. Oberg
Filed: 26 Jul 21
Utility
Apparatus and Method for Cryogranulating a Pharmaceutical Composition
21 Oct 21
Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium.
Edwin Amoro, Karel Vanackere, Michael A. White
Filed: 30 Jun 21
Utility
Composition and method for reducing hypoglycemia events in diabetes treatment
7 Sep 21
An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose.
Marshall Grant, Simon R. Bruce, Robert A. Baughman
Filed: 21 Jun 19
Utility
Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
31 Aug 21
Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.
Mark Hokenson, Keith A. Oberg
Filed: 4 Oct 18
Utility
Reactor for producing pharmaceutical particles in a precipitation process
31 Aug 21
Reactors, reactor systems and methods for producing particles in a precipitation process are provided.
Sanket Gandhi, Karen Moraleda, Jadwiga Jachowicz, Michael Zupon
Filed: 7 Mar 18
Utility
Method and Composition for Treating Obesity
26 Aug 21
A method for treating obesity associated to Prader Willi Syndrome and/or binge eating is disclosed.
Michael CASTAGNA, David KENDALL, Kelly KRAFT, Chad C. SMUTNEY, Marshall GRANT
Filed: 25 Apr 19
Utility
Heat-stable Dry Powder Pharmaceutical Compositions and Methods
12 Aug 21
Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition.
Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay
Filed: 27 Apr 21
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