117 patents
Page 2 of 6
Utility
Dry Powder Inhalation System
18 May 23
Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed.
Chad C. Smutney, P. Spencer Kinsey, John M. Polidoro, Carl R. Sahi, Benoit Adamo, Scott McLean, Dennis Overfield, Anthony Bryant
Filed: 20 Jan 23
Utility
Use of Ultrarapid Acting Insulin
11 May 23
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
Anders Hasager Boss, Richard Petrucci, Campbell Howard, Alfred Mann
Filed: 8 Dec 22
Utility
Hydraulically actuated pump for fluid administration
9 May 23
A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid.
Robert R. Gonnelli, Devin V. McAllister, Steven F. Levesque
Filed: 18 Nov 19
Utility
Methods and Compositions for Treating Pulmonary Hypertension
27 Apr 23
Inhalable compositions for treating pulmonary hypertension comprising treprostinil, derivative thereof or analogs thereof and a method for treating pulmonary arterial hypertension and/or idiopathic pulmonary fibrosis are disclosed herein.
John J. Freeman, Marshall L. Grant, Jason J. Antunovich, William Elliott Bay
Filed: 27 Oct 22
Utility
Dry powder drug delivery system and methods
11 Apr 23
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation.
Chad C. Smutney, Benoit Adamo, Brendan F. Laurenzi, P. Spencer Kinsey
Filed: 8 Jul 20
Utility
Dry Powder Inhaler
30 Mar 23
A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed.
P. Spencer Kinsey, Brendan Laurenzi, Chad C. Smutney, Benoit Adamo, Joseph Guarneri, John J. Freeman, JR.
Filed: 9 Nov 22
Utility
Diketopiperazine microparticles with defined specific surface areas
21 Mar 23
Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g.
Marshall L. Grant, Grayson W. Stowell, Paul Menkin, John J. Freeman, Jr.
Filed: 14 Aug 20
Utility
Methods for the Synthesis of Activated Ethylfumarates and Their Use As Intermediates
23 Feb 23
Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis.
Kelly Sullivan Kraft, John J. Freeman, Paul Serwinski, Vincent Pavia, Otto Phanstiel, Navneet Kaur
Filed: 24 Oct 22
Utility
Formation of N-Protected 3,6-bis-(4-aminoalkyl)-2,5,diketopiperazine
2 Feb 23
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids.
John J. Freeman, Adrienne Stamper, Melissa Heitmann
Filed: 12 Sep 22
Utility
Use of ultrarapid acting insulin
24 Jan 23
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
Anders Hasager Boss, Richard Petrucci, Campbell Howard, Alfred Mann
Filed: 14 Aug 20
Utility
High Capacity Diketopiperazine Microparticles and Methods
19 Jan 23
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent.
Marshall Grant, Paul Menkin, Grayson W. Stowell
Filed: 26 Jul 22
Utility
Method of Preventing Adverse Effects by GLP-1
8 Dec 22
A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like peptide 1 (GLP-1) therapy is provided.
Peter Richardson, Robert A. Baughman, Donald Costello
Filed: 15 Aug 22
Utility
Compositions of Clofazimine, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them
24 Nov 22
The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of dry powder, and processes for their preparation.
Thomas Hofmann, Stefan Ufer, Kevin Stapleton
Filed: 1 Nov 20
Utility
Delivery of Active Agents
17 Nov 22
A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein.
Peter Richardson, Robert A. Baughman, Andrea Leone-Bay, Donald Costello
Filed: 14 Jul 22
Utility
Methods for the synthesis of activated ethylfumarates and their use as intermediates
25 Oct 22
Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis.
Kelly Sullivan Kraft, John J. Freeman, Paul Serwinski, Vincent Pavia, Otto Phanstiel, Navneet Kaur
Filed: 7 Dec 20
Utility
Apparatus, system and method for detecting and monitoring inhalations
25 Oct 22
Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system.
John J. Pocreva, III, Benoit Adamo, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
Filed: 19 May 17
Utility
Insufflation apparatus and methods
20 Sep 22
An insufflation apparatus and methods for using same are disclosed.
Benoit Adamo, Brendan F. Laurenzi, Chad C. Smutney
Filed: 5 Aug 14
Utility
Formation of N-protected 3,6-BIS-(4-AMINOBUTYL)-2,5-DIKETOPIPERAZINE Through a Cyclic Alpha-n-protected Amino Ester
15 Sep 22
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided.
John J. Freeman, Otto Phanstiel, William Elliot Bay, Kelly Sullivan Kraft
Filed: 27 May 22
Utility
Formation of N-protected 3,6-bis-(4-aminoalkyl)-2,5,diketopiperazine
13 Sep 22
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids.
John J. Freeman, Adrienne Stamper, Melissa Heitmann
Filed: 4 May 20
Utility
High capacity diketopiperazine microparticles and methods
6 Sep 22
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent.
Marshall Grant, Paul Menkin, Grayson W. Stowell
Filed: 10 Jan 20