117 patents
Page 5 of 6
Utility
Microcrystalline Diketopiperazine Compositions and Methods
28 Oct 20
Disclosed herein are DKP microcrystals made by an improved method where they do not irreversibly self-assemble into microparticles.
Bryan R. Wilson, Joseph J. Guarneri, Marshall L. Grant
Filed: 8 Jul 20
Utility
Diketopiperazine microparticles with defined specific surface areas
14 Sep 20
Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g.
Marshall L. Grant, Grayson W. Stowell, Paul Menkin, John J. Freeman, Jr.
Filed: 16 Mar 17
Utility
Use of ultrarapid acting insulin
14 Sep 20
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
Anders Hasager Boss, Richard Petrucci, Campbell Howard, Alfred Mann
Filed: 28 Jun 18
Utility
Dry powder inhaler and system for drug delivery
24 Aug 20
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided.
Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro
Filed: 12 Apr 16
Utility
Formation of N-Protected 3,6-bis-(4-aminoalkyl)-2,5,diketopiperazine
19 Aug 20
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids.
John J. Freeman, Adrienne Stamper, Melissa Heitmann
Filed: 3 May 20
Utility
Dry powder drug delivery system and methods
17 Aug 20
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation.
Chad C. Smutney, Benoit Adamo, Brendan F. Laurenzi, P. Spencer Kinsey
Filed: 14 Sep 17
Utility
Microcrystalline diketopiperazine compositions and methods
17 Aug 20
Disclosed herein are DKP microcrystals made by an improved method where they do not irreversibly self-assemble into microparticles.
Bryan R. Wilson, Joseph J. Guarneri, Marshall L. Grant
Filed: 5 Aug 19
Utility
Interactive Apparatus and Method for Real-time Profiling of Inhalation Efforts
5 Aug 20
Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system.
Dennis Overfield, Carl R. Sahi, Benoit Adamo, P. Kinsey, Scott Mclean, John M. Polidoro, Chad C. Smutney
Filed: 20 Apr 20
Utility
Blister Package for Pharmaceutical Cartridges
29 Jul 20
A blister packaging for a pharmaceutical cartridge or capsule and methods of forming same are disclosed.
Michael S. Bergey
Filed: 12 Apr 20
Utility
Formation of N-protected 3,6-BIS-(4-AMINOBUTYL)-2,5-DIKETOPIPERAZINE Through a Cyclic Alpha-n-protected Amino Ester
24 Jun 20
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided.
John J. Freeman, Otto Phanstiel, William Elliot Bay, Kelly Sullivan Kraft
Filed: 1 Mar 20
Utility
Catalysis of Diketopiperazine Synthesis
17 Jun 20
Provided is a method for the synthesis of N-protected 3,6-bis-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ε-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
John J. Stevenson, Destardi Moye-Sherman
Filed: 23 Feb 20
Utility
Interactive apparatus and method for real-time profiling of inhalation efforts
8 Jun 20
Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system.
Dennis Overfield, Carl R. Sahi, Benoit Adamo, P. Spencer Kinsey, Scott McLean, John M. Polidoro, Chad C. Smutney
Filed: 11 May 16
Utility
Diketopiperazine Salts for Drug Delivery and Related Methods
27 May 20
Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same.
Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
Filed: 26 Jan 20
Utility
High Capacity Diketopiperazine Microparticles and Methods
13 May 20
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent.
Marshall Grant, Paul Menkin, Grayson W. Stowell
Filed: 9 Jan 20
Utility
Delivery of Active Agents
13 May 20
A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein.
Peter Richardson, Robert A. Baughman, Andrea Leone-Bay, Donald Costello
Filed: 12 Jan 20
Utility
Method for Treating Hyperglycemia with GLP-1
13 May 20
A method for treating hyperglycemia and/or diabetes in a subject is provided.
Donald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
Filed: 18 Dec 19
Utility
Method of Preventing Adverse Effects by GLP-1
13 May 20
A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like peptide 1 (GLP-1) therapy is provided.
Peter Richardson, Robert A. Baughman, Donald Costello
Filed: 13 Jan 20
Utility
Superior Control of Blood Glucose In Diabetes Treatment
6 May 20
Methods related to the treatment of diabetes and improving the control of blood glucose levels are provided.
Wayman Wendell Cheatham, Anders Hasager Boss
Filed: 6 Jan 20
Utility
Formation of N-protected 3,6-bis-(4-aminoalkyl)-2,5,diketopiperazine
4 May 20
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids.
John J. Freeman, Adrienne Stamper, Melissa Heitmann
Filed: 3 Feb 19
Utility
Dry Powder Inhalation System
22 Apr 20
Dry powder inhaler systems for pulmonary delivery of pharmaceuticals are disclosed.
Chad C. Smutney, P. Spencer Kinsey, John M. Polidoro, Carl R. Sahi, Benoit Adamo, Scott McLean, Dennis Overfield, Anthony Bryant
Filed: 17 Dec 19