49 patents
Utility
Diketopiperazine salts for drug delivery and related methods
16 Jan 24
Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same.
Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
Filed: 5 Jan 21
Utility
Apparatus and method for cryogranulating a pharmaceutical composition
12 Dec 23
Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium.
Edwin Amoro, Karel Vanackere, Michael A. White
Filed: 30 Jun 21
Utility
Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
24 Oct 23
The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of a suspension, and processes for their preparation.
Thomas Hofmann, Stefan Ufer, Kevin Stapleton
Filed: 22 Feb 21
Utility
Prodrugs of treprosiinil
24 Oct 23
Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
Hitesh Batra, Liang Guo, Patrick Poisson, Sri Harsha Tummala, Elizabeth Ann Harris
Filed: 8 Jun 21
Utility
Interactive apparatus and method for real-time profiling of inhalation efforts
24 Oct 23
Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system.
Dennis Overfield, Carl R. Sahi, Benoit Adamo, P. Kinsey, Scott McLean, John M. Polidoro, Chad C. Smutney
Filed: 21 Apr 20
Utility
Time delay mechanism for a hydraulic drug delivery device
22 Aug 23
A medicament delivery device may comprise a medicament chamber configured to hold a medicament, a plunger configured to move relative to the medicament chamber to expel the medicament from the medicament chamber, a pin configured to move from a first pin position wherein the pin prevents movement of the plunger to a second pin position wherein the pin allows movement of the plunger, an actuation assembly configured to move the pin from the first pin position to the second pin position, and a needle coupled to the medicament chamber.
Christopher Gregory, Geoffrey Jenkins
Filed: 11 Feb 22
Utility
Communication accessory for a drug delivery device
8 Aug 23
A medicament delivery assembly comprises a delivery device configured to deliver medicament to a user, a communication accessory releasably coupled to the delivery device, and one or more sensors configured to sense a condition of the delivery device.
Christopher Gregory, Geoffrey Jenkins, Matthew Johnson
Filed: 13 Jul 18
Utility
Fluid delivery device having an insertable prefilled cartridge
30 May 23
A fluid delivery device includes a housing having a bottom surface configured to be coupled to the skin surface.
Christopher C. Gregory, Matthew P. Johnson, Robert L. Standley
Filed: 6 Feb 20
Utility
Hydraulically actuated pump for fluid administration
9 May 23
A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid.
Robert R. Gonnelli, Devin V. McAllister, Steven F. Levesque
Filed: 18 Nov 19
Utility
Dry powder drug delivery system and methods
11 Apr 23
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation.
Chad C. Smutney, Benoit Adamo, Brendan F. Laurenzi, P. Spencer Kinsey
Filed: 8 Jul 20
Utility
Diketopiperazine microparticles with defined specific surface areas
21 Mar 23
Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g.
Marshall L. Grant, Grayson W. Stowell, Paul Menkin, John J. Freeman, Jr.
Filed: 14 Aug 20
Utility
Use of ultrarapid acting insulin
24 Jan 23
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
Anders Hasager Boss, Richard Petrucci, Campbell Howard, Alfred Mann
Filed: 14 Aug 20
Utility
Methods for the synthesis of activated ethylfumarates and their use as intermediates
25 Oct 22
Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis.
Kelly Sullivan Kraft, John J. Freeman, Paul Serwinski, Vincent Pavia, Otto Phanstiel, Navneet Kaur
Filed: 7 Dec 20
Utility
Apparatus, system and method for detecting and monitoring inhalations
25 Oct 22
Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system.
John J. Pocreva, III, Benoit Adamo, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
Filed: 19 May 17
Utility
Insufflation apparatus and methods
20 Sep 22
An insufflation apparatus and methods for using same are disclosed.
Benoit Adamo, Brendan F. Laurenzi, Chad C. Smutney
Filed: 5 Aug 14
Utility
Formation of N-protected 3,6-bis-(4-aminoalkyl)-2,5,diketopiperazine
13 Sep 22
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids.
John J. Freeman, Adrienne Stamper, Melissa Heitmann
Filed: 4 May 20
Utility
High capacity diketopiperazine microparticles and methods
6 Sep 22
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent.
Marshall Grant, Paul Menkin, Grayson W. Stowell
Filed: 10 Jan 20
Utility
Formation of N-protected 3,6-bis-(4-aminobutyl)-2,5-diketopiperazine through a cyclic α-N-protected amino ester
31 May 22
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided.
John J. Freeman, Otto Phanstiel, William Elliot Bay, Kelly Sullivan Kraft
Filed: 22 Dec 20
Utility
Inhalable dry powder pharmaceutical composition
19 Apr 22
A method for treating hyperglycemia and/or diabetes in a subject is provided.
Donald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
Filed: 19 Dec 19
Utility
Catalysis of diketopiperazine synthesis
5 Apr 22
Provided is a method for the synthesis of N-protected 3,6-bis-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ε-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
John J. Stevenson, Destardi Moye-Sherman
Filed: 24 Feb 20