98 patents
Utility
Alkoxylation methods
5 Dec 23
Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same.
Antoni Kozlowski, Samuel P. McManus, Sachin Tipnis, Greg Lavaty, David Swallow, John R. Handley, Anthony G. Schaefer
Filed: 2 Oct 20
Utility
Multi-arm Polymer Conjugates of TLR Agonist Compounds and Related Immunotherapeutic Treatment Methods
23 Nov 23
Zhongxu Ren, Neel K. Anand, Haiying Cai, Bo-Liang Deng, Bhalchandra V. Joshi, Jonathan Zalevsky, Takahiro Miyazaki, Saul Kivimae
Filed: 12 Jul 23
Utility
Multi-arm polymeric prodrug conjugates of taxane-based compounds
14 Nov 23
Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof.
Antoni Kozlowski, Timothy A. Riley, Samuel P. McManus
Filed: 7 Sep 18
Utility
Multi-arm polymer conjugates of TLR agonist compounds and related immunotherapeutic treatment methods
5 Sep 23
Zhongxu Ren, Neel K. Anand, Haiying Cai, Bo-Liang Deng, Bhalchandra V. Joshi, Jonathan Zalevsky, Takahiro Miyazaki, Saul Kivimae
Filed: 10 Jan 18
Utility
Conjugates of a Factor VIII Moiety Having an Oxime-containing Linkage
3 Aug 23
The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer.
Mary J. Bossard, Dawei Sheng
Filed: 27 Feb 23
Utility
Method for Enhancing Cellular Immunotherapy
25 May 23
Provided are methods and compositions directed to the treatment of an individual having cancer by (i) administering to the individual an adoptive cellular immunotherapy composition comprising CAR T cells and (ii) administering to the individual an interleukin-15 receptor agonist, such as, for example, a long-acting interleukin-15 receptor agonist.
Antonio Mario Querido Marcondes, Peter Benedict Kirk, Takahiro Miyazaki, Cameron J. Turtle, Stanley R. Riddell, Cassie K. Chou, Simon P. Fräßle
Filed: 4 Apr 20
Utility
Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
25 Apr 23
Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction.
Sean M. Culbertson, Xiaoming Shen, Antoni Kozlowski, Samuel P. McManus
Filed: 30 Nov 21
Utility
Conjugates of a factor VIII moiety having an oxime-containing linkage
18 Apr 23
The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer.
Mary J. Bossard, Dawei Sheng
Filed: 21 Jul 17
Utility
Polymer Derivatives Having Particular Atom Arrangements
13 Apr 23
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group.
J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
Filed: 9 Aug 22
Utility
Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds
28 Mar 23
Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of pemetrexed-based compounds.
Lin Cheng, Jennifer Riggs-Sauthier
Filed: 25 Jun 20
Utility
Oligomer-corticosteroid conjugates
11 Oct 22
The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer.
Wen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
Filed: 19 Oct 17
Utility
Polymer derivatives having particular atom arrangements
20 Sep 22
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group.
J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
Filed: 6 Apr 20
Utility
Polymer-sunitinib conjugates
23 Aug 22
The invention relates to (among other things) polymer-sunitinib conjugates and related compounds.
Sean M. Culbertson, Antoni Kozlowski, Tony Drew Vinson
Filed: 7 May 20
Utility
Polymer-des-ethyl sunitinib conjugates
9 Aug 22
The invention relates to (among other things) polymer-des-ethyl sunitinib conjugates and related compounds.
Antoni Kozlowski, Sean M. Culbertson, Xiaoming Shen, Samuel P. McManus, Mark A. Wilson
Filed: 9 Jan 19
Utility
Adenosine 2 Receptor Antagonists
28 Jul 22
The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using.
Neel K. Anand, Natalia Aurrecoechea, Anthony James Brockway, Haiying Cai, Lin Cheng, Bo-Liang Deng, Donogh John Roger O'Mahony, Zhongxu Ren, Wen Zhang
Filed: 1 May 20
Utility
Composition Comprising a Polymeric Reagent
12 May 22
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates.
Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
Filed: 27 Jan 22
Utility
Immunotherapeutic treatment method using an interleukin-2 receptor beta-selective agonist in combination with adoptive cell transfer therapy
3 May 22
Provided are methods and compositions directed towards the treatment of an individual having cancer by providing adoptive cell transfer therapy and administering to the individual a long-acting IL-2Rβ-biased agonist.
Deborah H. Charych, Antoni Ribas, Giulia Parisi
Filed: 1 Mar 18
Utility
Multi-arm Polymer Prodrugs
17 Mar 22
Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same.
Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
Filed: 24 Nov 21
Utility
Polymeric Alpha-hydroxy Aldehyde and Ketone Reagents and Conjugation Method
17 Mar 22
Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction.
Sean M. Culbertson, Xiaoming Shen, Antoni Kozlowski, Samuel P. McManus
Filed: 30 Nov 21
Utility
Oligomer-corticosteroid Conjugates
10 Mar 22
The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer.
Wen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
Filed: 16 Nov 21