48 patents
Utility
Alkoxylation methods
5 Dec 23
Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same.
Antoni Kozlowski, Samuel P. McManus, Sachin Tipnis, Greg Lavaty, David Swallow, John R. Handley, Anthony G. Schaefer
Filed: 2 Oct 20
Utility
Multi-arm polymeric prodrug conjugates of taxane-based compounds
14 Nov 23
Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof.
Antoni Kozlowski, Timothy A. Riley, Samuel P. McManus
Filed: 7 Sep 18
Utility
Multi-arm polymer conjugates of TLR agonist compounds and related immunotherapeutic treatment methods
5 Sep 23
Zhongxu Ren, Neel K. Anand, Haiying Cai, Bo-Liang Deng, Bhalchandra V. Joshi, Jonathan Zalevsky, Takahiro Miyazaki, Saul Kivimae
Filed: 10 Jan 18
Utility
Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
25 Apr 23
Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction.
Sean M. Culbertson, Xiaoming Shen, Antoni Kozlowski, Samuel P. McManus
Filed: 30 Nov 21
Utility
Conjugates of a factor VIII moiety having an oxime-containing linkage
18 Apr 23
The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer.
Mary J. Bossard, Dawei Sheng
Filed: 21 Jul 17
Utility
Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds
28 Mar 23
Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of pemetrexed-based compounds.
Lin Cheng, Jennifer Riggs-Sauthier
Filed: 25 Jun 20
Utility
Oligomer-corticosteroid conjugates
11 Oct 22
The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer.
Wen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
Filed: 19 Oct 17
Utility
Polymer derivatives having particular atom arrangements
20 Sep 22
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group.
J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
Filed: 6 Apr 20
Utility
Polymer-sunitinib conjugates
23 Aug 22
The invention relates to (among other things) polymer-sunitinib conjugates and related compounds.
Sean M. Culbertson, Antoni Kozlowski, Tony Drew Vinson
Filed: 7 May 20
Utility
Polymer-des-ethyl sunitinib conjugates
9 Aug 22
The invention relates to (among other things) polymer-des-ethyl sunitinib conjugates and related compounds.
Antoni Kozlowski, Sean M. Culbertson, Xiaoming Shen, Samuel P. McManus, Mark A. Wilson
Filed: 9 Jan 19
Utility
Immunotherapeutic treatment method using an interleukin-2 receptor beta-selective agonist in combination with adoptive cell transfer therapy
3 May 22
Provided are methods and compositions directed towards the treatment of an individual having cancer by providing adoptive cell transfer therapy and administering to the individual a long-acting IL-2Rβ-biased agonist.
Deborah H. Charych, Antoni Ribas, Giulia Parisi
Filed: 1 Mar 18
Utility
Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
8 Mar 22
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates.
Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
Filed: 19 May 20
Utility
N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the κ opioid receptor
8 Feb 22
Compounds and pharmaceutically acceptable salts and solvates thereof are described.
Franco J. Duarte, Neel K. Anand, Wen Zhang, Pankaj Sharma, Devendrapratap Singh
Filed: 14 May 19
Utility
Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
11 Jan 22
Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction.
Sean M. Culbertson, Xiaoming Shen, Antoni Kozlowski, Samuel P. McManus
Filed: 23 Jul 20
Utility
Method of making a water-soluble polymer-factor VIII moiety conjugate
12 Oct 21
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided.
Mary J. Bossard, Michael D. Bentley, Ping Zhang
Filed: 17 May 18
Utility
Chemically modified small molecules
28 Sep 21
Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchioalveolar lavage followed by assaying residual lung material.
C. Simone Jude-Fishburn, David Lechuga-Ballesteros, Tacey X. Viegas, Mei-Chang Kuo, Hema Gursahani, Chester Leach, Yuan Song
Filed: 27 Jun 18
Utility
Method of preparing carboxylic acid functionalized polymers
7 Sep 21
Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods.
J. Milton Harris, Antoni Kozlowski, Lihong Guo
Filed: 5 Jun 18
Utility
Kappa opioid agonists and uses thereof
7 Sep 21
Neel K. Anand, Franco J. Duarte, Wen Zhang, Zhongxu Ren
Filed: 1 Aug 19
Utility
Method of refolding an interleukin-2 (IL-2) protein
17 Aug 21
Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided.
Jicai Huang, Yujun Wang
Filed: 24 Sep 18
Utility
Methods of treating CYP2D6 alternative metabolizers
15 Jun 21
The invention provides various methods comprising the administration of a CYP2D6 bioactive drug covalently bound to a water-soluble oligomer.
Michael A. Eldon, C. Simone Jude-Fishburn, Hema Gursahani, Myong Gyong Lee
Filed: 9 Jun 09