56 patents
Utility
Multiplex targeted amplification using flap nuclease
21 Nov 23
Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed.
Jianbiao Zheng, Li Weng, Malek Faham
Filed: 26 Oct 20
Utility
Array-based Methods for Analysing Mixed Samples Using Differently Labelled Allele-specific Probes
26 Oct 23
This disclosure provides methods and systems useful in array-based analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies).
Ronald SAPOLSKY, Michael SHAPERO, Jeanette SCHMIDT, Eric FUNG, Orna MIZRAHI MAN, Jiang LI, Monica CHADHA, Anju SHUKLA
Filed: 20 Dec 22
Utility
Viterbi Decoder for Microarray Signal Processing
5 Oct 23
A system and method for region-based calling utilizes a probability distribution of a phi-transformed logarithmic ratio to determine a set of possible transition paths through markers and marker states, constructs a local evidence matrix for each of the markers and generates a total per-marker value for each segment in a discrete region.
Benjamin BOLSTAD, Alan ROTER, Radharani DUTTAGUPTA
Filed: 20 Feb 23
Utility
Methods for identifying DNA copy number changes using hidden markov model based estimations
23 May 23
Methods for estimating genomic copy number and loss of heterozygosity using Hidden Markov Model based estimation are disclosed.
Srinka Ghosh
Filed: 10 Jan 19
Utility
UV Excitable Polyfluorene Based Conjugates and Their Use in Methods of Analyte Detection
27 Apr 23
The invention provides for UV excitable polyfluorene based conjugates and their use in methods of analyte detection.
Zhenjun Diwu, Haitao Guo, Ruogu Peng, Travis Jennings
Filed: 28 Jan 21
Utility
Array-based methods for analysing mixed samples using differently labelled allele-specific probes
14 Mar 23
This disclosure provides methods and systems useful in array-based analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies).
Ronald Sapolsky, Michael Shapero, Jeanette Schmidt, Eric Fung, Orna Mizrahi Man, Jiang Li, Monica Chadha, Anju Shukla
Filed: 1 Jun 18
Utility
Viterbi decoder for microarray signal processing
28 Feb 23
A system and method for region-based calling utilizes a probability distribution of a phi-transformed logarithmic ratio to determine a set of possible transition paths through markers and marker states, constructs a local evidence matrix for each of the markers and generates a total per-marker value for each segment in a discrete region.
Benjamin Bolstad, Alan Roter, Radharani Duttagupta
Filed: 17 Oct 18
Utility
Enzymatic methods for genotyping on arrays
7 Feb 23
The invention relates to methods for enzymatic, genotyping of polymorphisms on solid supports.
Glenn K. Fu, Keith W. Jones
Filed: 13 Dec 19
Utility
Array-based Methods for Analysing Mixed Samples Using Differently Labelled Allele-specific Probes
5 Jan 23
This disclosure provides methods and kits useful in analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications, and aneuploidies).
Michael SHAPERO, Ronald SAPOLSKY, Eric FUNG, Jeanette SCHMIDT, Monica CHADHA, Anju SHUKLA
Filed: 12 Sep 22
Utility
Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies
27 Dec 22
Provided includes methods and systems useful in array-based analysis of mixed nucleic acid populations, including for genotyping and copy number analysis of the various subpopulations of the mixed nucleic acid population.
Jeanette Schmidt, Orna Mizrahi Man, Jiang Li
Filed: 1 Jun 18
Utility
Locus Specific Amplification Using Array Probes
24 Nov 22
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets.
Glenn FU, Michael SHAPERO, Pei-Hua WANG
Filed: 5 Aug 22
Utility
Array-based methods for analysing mixed samples using differently labelled allele-specific probes
13 Sep 22
This disclosure provides methods and kits useful in analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies).
Michael Shapero, Ronald Sapolsky, Eric Fung, Jeanette Schmidt, Monica Chadha, Anju Shukla
Filed: 1 Jun 18
Utility
Locus specific amplification using array probes
9 Aug 22
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets.
Glenn Fu, Michael Shapero, Pei-Hua Wang
Filed: 3 May 19
Utility
Array-based Translocation and Rearrangement Assays
30 Jun 22
Methods for detecting genomic rearrangements are provided.
Andrew Sparks, Michael H. Shapero, Glenn K. Fu, Keith W. Jones
Filed: 8 Sep 20
Utility
Methods of determining the presence or absence of a plurality of target polynucleotides in a sample
3 May 22
A method for detecting the presence or absence of a target polynucleotide in a sample is described.
John D. Curry, Heather Koshinsky, Amanda K. Lindholm-Perry, Richard M. Thallman
Filed: 26 Feb 20
Utility
Methods for genotyping
19 Apr 22
The present invention provides for methods for discriminating between alleles at polymorphic positions in a genome.
Michael H. Shapero
Filed: 9 Oct 18
Utility
Methods for synthesizing pools of probes
15 Mar 22
Compositions, methods and kits are disclosed for synthesizing and amplifying pools of probes using precursor oligonucleotides.
Yuker Wang, Keith W. Jones, Ronald J. Sapolsky
Filed: 17 Oct 19
Utility
Multiplex amplification methods
1 Mar 22
Compositions and methods for amplifying selected polynucleotides, including DNA and RNA, particularly in multiplex amplification reactions using common primers amplification.
Eugeni A. Namsaraev
Filed: 17 Oct 17
Utility
Nucleic Acid Analysis by Joining Barcoded Polynucleotide Probes
17 Feb 22
Disclosed are compositions, methods and kits for determining the presence, absence, amount, copy number, or other characteristics of one or more polynucleotide sequences in two or more samples and use thereof in genotyping, evaluation of copy number variation, expression analysis, determination of splice variants and fusion genes, and other genetic analyses.
Heather KOSHINSKY, John D. CURRY, Robert O'CALLAHAN, Adam MCCOY, Daniel FITZPATRICK, Philip H. DICKINSON, Anthony C. SCHWEITZER
Filed: 27 Aug 21
Utility
Amplification and Analysis of Selected Targets on Solid Supports
10 Feb 22
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets.
Glenn K. Fu, Glenn H. Mcgall, Robert G. Kuimelis, Jing Hu, Pei-Hua Wang
Filed: 19 Jan 21