56 patents
Page 2 of 3
Utility
Nucleic acid analysis by joining barcoded polynucleotide probes
14 Sep 21
Disclosed are compositions, methods and kits for determining the presence, absence, amount, copy number, or other characteristics of one or more polynucleotide sequences in two or more samples and use thereof in genotyping, evaluation of copy number variation, expression analysis, determination of splice variants and fusion genes, and other genetic analyses.
Heather Koshinsky, John D. Curry, Robert O'Callahan, Adam McCoy, Daniel Fitzpatrick, Philip H. Dickinson, Anthony C. Schweitzer
Filed: 8 Nov 16
Utility
Array Based Method and Kit for Determining Copy Number and Genotype In Pseudogenes
26 Aug 21
Provided herein are methods and associated compositions, kits, systems, devices and instruments useful for genetic analysis where there is/are a sequence(s) similar to the gene of interest in a sample.
Alan ROTER, Jeanette SCHMIDT, Longyang WU, Rama Rajaraja VARMA, Zheng CAI, Thao-Nhi LE, Srividya MOHAN, Kay AULL
Filed: 23 Jul 19
Utility
Detection Device and Method
24 Jun 21
A system and method utilizes multi-sample batch controls for high throughput copy number calling in a small number of fixed regions where copy number changes are expected.
Olga KAMNEVA, Jeremy GOLLUB, Rama VARMA
Filed: 17 Oct 18
Utility
System, Method, and Computer Software Product for Genotype Determination Using Probe Array Data
10 Jun 21
An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate.
Earl A. Hubbell, Simon Cawley
Filed: 9 Nov 20
Utility
Methods of Analysis of Methylation
20 May 21
Methods for determining the methylation status of a plurality of cytosines are disclosed.
Shivani Nautiyal, Malek Faham
Filed: 26 Oct 20
Utility
Array-based Methods for Analysing Mixed Samples Using Different Allele-specific Labels, In Particular for Detection of Fetal Aneuploidies
20 May 21
Provided includes methods and systems useful in array-based analysis of mixed nucleic acid populations, including for genotyping and copy number analysis of the various subpopulations of the mixed nucleic acid population.
Jeanette SCHMIDT, Orna MIZRAHI MAN, Jiang LI
Filed: 1 Jun 18
Utility
Array-based Methods for Analysing Mixed Samples Using Differently Labelled Allele-specific Probes
20 May 21
This disclosure provides methods and systems useful in array-based analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies).
Ronald SAPOLSKY, Michael SHAPERO, Jeanette SCHMIDT, Eric FUNG, Orna MIZRAHI MAN, Jiang LI, Monica CHADHA, Anju SHUKLA
Filed: 1 Jun 18
Utility
Array-based Methods for Analysing Mixed Samples Using Differently Labelled Allele-specific Probes
20 May 21
This disclosure provides methods and kits useful in analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies).
Michael SHAPERO, Ronald SAPOLSKY, Eric FUNG, Jeanette SCHMIDT, Monica CHADHA, Anju SHUKLA
Filed: 1 Jun 18
Utility
Methods, systems and apparatuses for testing and calibrating fluorescent scanners
18 May 21
Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them.
Bei-Shen Sywe, Mark Borodkin, Chuan Gao, Liana Ilkova, Devin Nguyen
Filed: 13 Aug 19
Utility
Multiplex Targeted Amplification Using Flap Nuclease
29 Apr 21
Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed.
Jianbiao Zheng, Li Weng, Malek Faham
Filed: 26 Oct 20
Utility
Methods and devices for reading microarrays
13 Apr 21
In one embodiment of the invention, a method to image a probe array is described that includes focusing on a plurality of fiducials on a surface of an array.
David Stern, Chuan Gao, Melvin Yamamoto, Devin Nguyen
Filed: 21 Jan 20
Utility
Amplification and analysis of selected targets on solid supports
16 Feb 21
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets.
Glenn K. Fu, Glenn H. Mcgall, Robert G. Kuimelis, Jing Hu, Pei-Hua Wang
Filed: 23 Apr 18
Utility
Differential filtering of genetic data
21 Dec 20
Computer software products, methods, and systems are described which provide functionality to a user conducting experiments designed to detect and/or identify genetic sequences and other characteristics of a genetic sample, such as, for instance, gene copy number and aberrations thereof.
Carl A. Dowds, Jody C. McIntyre, Edgar E. Erwin, Garret D. Wilson, Pragna B. Parmar, Breck S. Ohlson, Richard D. Shippy, Francisco J. Cifuentes
Filed: 21 Sep 17
Utility
System, method, and computer software product for genotype determination using probe array data
9 Nov 20
An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate.
Earl A. Hubbell, Simon Cawley
Filed: 16 Aug 17
Utility
Methods of analysis of methylation
2 Nov 20
Methods for determining the methylation status of a plurality of cytosines are disclosed.
Shivani Nautiyal, Malek Faham
Filed: 30 Jul 19
Utility
Multiplex targeted amplification using flap nuclease
2 Nov 20
Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed.
Jianbiao Zheng, Li Weng, Malek Faham
Filed: 1 Oct 18
Utility
Analysis of methylation using nucleic acid arrays
2 Nov 20
Arrays for genome-wide analysis of methylation are disclosed.
Yanxiang Cao, Shivani Nautiyal, Charles G. Miyada, Christopher Davies, Gangwu Mei, Alan J. Williams, Eric B. Schell, John E. Blume
Filed: 23 Oct 17
Utility
Dna Ligation on Rna Template
14 Oct 20
Disclosed are methods and compositions for detection and amplification of nucleic acids, wherein two DNA strands hybridized to an RNA strand are ligated.
Eugeni A. NAMSARAEV, Xin MIAO, John E. BLUME
Filed: 2 Apr 20
Utility
Viterbi Decoder for Microarray Signal Processing
16 Sep 20
A system and method for region-based calling utilizes a probability distribution of a phi-transformed logarithmic ratio to determine a set of possible transition paths through markers and marker states, constructs a local evidence matrix for each of the markers and generates a total per-marker value for each segment in a discrete region.
Benjamin BOLSTAD, Alan ROTER, Radharani DUTTAGUPTA
Filed: 16 Oct 18
Utility
Methods and Devices for Reading Microarrays
19 Aug 20
In one embodiment of the invention, a method to image a probe array is described that includes focusing on a plurality of fiducials on a surface of an array.
David Stern, Chuan Gao, Melvin Yamamoto, Devin Nguyen
Filed: 20 Jan 20