27 patents
Utility
Multiplex targeted amplification using flap nuclease
21 Nov 23
Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed.
Jianbiao Zheng, Li Weng, Malek Faham
Filed: 26 Oct 20
Utility
Methods for identifying DNA copy number changes using hidden markov model based estimations
23 May 23
Methods for estimating genomic copy number and loss of heterozygosity using Hidden Markov Model based estimation are disclosed.
Srinka Ghosh
Filed: 10 Jan 19
Utility
Array-based methods for analysing mixed samples using differently labelled allele-specific probes
14 Mar 23
This disclosure provides methods and systems useful in array-based analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies).
Ronald Sapolsky, Michael Shapero, Jeanette Schmidt, Eric Fung, Orna Mizrahi Man, Jiang Li, Monica Chadha, Anju Shukla
Filed: 1 Jun 18
Utility
Viterbi decoder for microarray signal processing
28 Feb 23
A system and method for region-based calling utilizes a probability distribution of a phi-transformed logarithmic ratio to determine a set of possible transition paths through markers and marker states, constructs a local evidence matrix for each of the markers and generates a total per-marker value for each segment in a discrete region.
Benjamin Bolstad, Alan Roter, Radharani Duttagupta
Filed: 17 Oct 18
Utility
Enzymatic methods for genotyping on arrays
7 Feb 23
The invention relates to methods for enzymatic, genotyping of polymorphisms on solid supports.
Glenn K. Fu, Keith W. Jones
Filed: 13 Dec 19
Utility
Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies
27 Dec 22
Provided includes methods and systems useful in array-based analysis of mixed nucleic acid populations, including for genotyping and copy number analysis of the various subpopulations of the mixed nucleic acid population.
Jeanette Schmidt, Orna Mizrahi Man, Jiang Li
Filed: 1 Jun 18
Utility
Array-based methods for analysing mixed samples using differently labelled allele-specific probes
13 Sep 22
This disclosure provides methods and kits useful in analysis of mixed nucleic acid populations, including for multiplex genotyping of a mixed nucleic acid sample and for detecting differences in copy number of a target polynucleotide and/or a target chromosome (e.g., microdeletions, duplications and aneuploidies).
Michael Shapero, Ronald Sapolsky, Eric Fung, Jeanette Schmidt, Monica Chadha, Anju Shukla
Filed: 1 Jun 18
Utility
Locus specific amplification using array probes
9 Aug 22
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets.
Glenn Fu, Michael Shapero, Pei-Hua Wang
Filed: 3 May 19
Utility
Methods of determining the presence or absence of a plurality of target polynucleotides in a sample
3 May 22
A method for detecting the presence or absence of a target polynucleotide in a sample is described.
John D. Curry, Heather Koshinsky, Amanda K. Lindholm-Perry, Richard M. Thallman
Filed: 26 Feb 20
Utility
Methods for genotyping
19 Apr 22
The present invention provides for methods for discriminating between alleles at polymorphic positions in a genome.
Michael H. Shapero
Filed: 9 Oct 18
Utility
Methods for synthesizing pools of probes
15 Mar 22
Compositions, methods and kits are disclosed for synthesizing and amplifying pools of probes using precursor oligonucleotides.
Yuker Wang, Keith W. Jones, Ronald J. Sapolsky
Filed: 17 Oct 19
Utility
Multiplex amplification methods
1 Mar 22
Compositions and methods for amplifying selected polynucleotides, including DNA and RNA, particularly in multiplex amplification reactions using common primers amplification.
Eugeni A. Namsaraev
Filed: 17 Oct 17
Utility
Nucleic acid analysis by joining barcoded polynucleotide probes
14 Sep 21
Disclosed are compositions, methods and kits for determining the presence, absence, amount, copy number, or other characteristics of one or more polynucleotide sequences in two or more samples and use thereof in genotyping, evaluation of copy number variation, expression analysis, determination of splice variants and fusion genes, and other genetic analyses.
Heather Koshinsky, John D. Curry, Robert O'Callahan, Adam McCoy, Daniel Fitzpatrick, Philip H. Dickinson, Anthony C. Schweitzer
Filed: 8 Nov 16
Utility
Methods, systems and apparatuses for testing and calibrating fluorescent scanners
18 May 21
Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them.
Bei-Shen Sywe, Mark Borodkin, Chuan Gao, Liana Ilkova, Devin Nguyen
Filed: 13 Aug 19
Utility
Methods and devices for reading microarrays
13 Apr 21
In one embodiment of the invention, a method to image a probe array is described that includes focusing on a plurality of fiducials on a surface of an array.
David Stern, Chuan Gao, Melvin Yamamoto, Devin Nguyen
Filed: 21 Jan 20
Utility
Amplification and analysis of selected targets on solid supports
16 Feb 21
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets.
Glenn K. Fu, Glenn H. Mcgall, Robert G. Kuimelis, Jing Hu, Pei-Hua Wang
Filed: 23 Apr 18
Utility
Differential filtering of genetic data
21 Dec 20
Computer software products, methods, and systems are described which provide functionality to a user conducting experiments designed to detect and/or identify genetic sequences and other characteristics of a genetic sample, such as, for instance, gene copy number and aberrations thereof.
Carl A. Dowds, Jody C. McIntyre, Edgar E. Erwin, Garret D. Wilson, Pragna B. Parmar, Breck S. Ohlson, Richard D. Shippy, Francisco J. Cifuentes
Filed: 21 Sep 17
Utility
System, method, and computer software product for genotype determination using probe array data
9 Nov 20
An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate.
Earl A. Hubbell, Simon Cawley
Filed: 16 Aug 17
Utility
Methods of analysis of methylation
2 Nov 20
Methods for determining the methylation status of a plurality of cytosines are disclosed.
Shivani Nautiyal, Malek Faham
Filed: 30 Jul 19
Utility
Multiplex targeted amplification using flap nuclease
2 Nov 20
Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed.
Jianbiao Zheng, Li Weng, Malek Faham
Filed: 1 Oct 18