1904 patents
Utility
Systems and Methods for Identifying Sequence Variation
18 Jan 24
Systems and method for determining variants can receive mapped reads, and call variants.
Fiona HYLAND, Eric TSUNG, Vasisht TADIGOTLA, Zheng ZHANG, Dumitru BRINZA, Onur SAKARYA, Xing XU
Filed: 7 Jun 23
Utility
System and Method for Preparation and Delivery of Biological Samples for Charged Particle Analysis
18 Jan 24
Systems and method for the preparation and delivery of biological samples for charged particle analysis are disclosed herein.
Marcus STRAW, Dmitry GRINFELD, Alexander MAKAROV, Alan BAHM, Aaron TOROK, Kun LIU, Joseph CHRISTIAN, Josh GILBERT, Tom NICHOLS, Jeff KOSMOSKI
Filed: 18 Jul 23
Utility
Inert Non-adsorbing Crimpable Capillaries and Devices for Adjusting Gas Flow In Isotope Ratio Analysis
18 Jan 24
A gas transfer system for transferring gas into an analytical instrument for isotope ratio analysis comprises a capillary for delivering sample and/or reference gas from a gas source, a first connector for connecting the capillary to the gas source, a second connector for connecting the capillary to the analytical instrument, a crimping device, wherein the internal surface of the capillary comprises a coating material to prevent or minimize adsorption of water to the surface.
Michael KRUMMEN, Jens RADKE, Johannes SCHWIETERS, Nils STÖEBENER, Ronald SEEDORF
Filed: 25 Sep 23
Utility
Removable Ion Source Capable Of Axial Or Cross Beam Ionization
18 Jan 24
An ion source including an ionization assembly, first and second electron sources, and a magnet assembly.
Edward B. McCauley, Dustin Donald Holden
Filed: 19 Nov 21
Utility
Sequencing methods using improved nucleotide reagent solutions
16 Jan 24
A reagent solution includes water, a nucleotide, and tris(2-carboxyethyl)phosphine in a range of 0.5 μM to 1000 μM.
Jamsheed Ghadiri, Karta Atehortua-Khalsa
Filed: 7 Jan 22
Utility
Umbrella check valve assembly having retention plate
16 Jan 24
A check valve assembly includes a first port fitting and a second port fitting with a base secured therebetween.
Charles R. Rhodes, Jonathan O. Schultz
Filed: 30 Jan 23
Utility
Integrated sensor arrays for biological and chemical analysis
16 Jan 24
Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions.
Jonathan M. Rothberg, Wolfgang Hinz, John F. Davidson, Antoine M. van Oijen, John Leamon, Martin Huber, Mark James Milgrew, James Bustillo
Filed: 31 Aug 22
Utility
Compositions and methods for efficient delivery of molecules to cells
16 Jan 24
The present invention provides lipid aggregate compositions having at least two cationic lipids in combination with one or optionally more than one non-cationic lipids for the in vitro and/or in vivo delivery of biologically active molecules including nucleic acids, specifically DNA and RNA, and proteins into cells and tissues.
Xavier de Mollerat du Jeu, Nektaria Andronikou
Filed: 5 Oct 20
Utility
Liquisoft capsules
16 Jan 24
Described herein are oral pharmaceutical compositions suitable for chewing, sucking, or buccal dissolution comprising soft gel capsules and liquid fills, methods for making the same, and methods for treating subjects in need thereof with such capsules.
YinYan Zhao, Yunhua Hu, Mervin Williams, Jr., Tatyana Dyakonov, Saujanya Gosangari, Chue Yang, Henricus Marinus Gerardus Maria Van Duijnhoven, Martin Piest, Aqeel A. Fatmi
Filed: 25 Mar 22
Utility
Reagent container and methods of use
16 Jan 24
A reagent container includes a base defining a plurality of wells having openings exposed at an upper surface of the base and a tube receptacle.
Earl Zergiebel
Filed: 19 Jun 20
Utility
Methods and apparatus for high speed mass spectrometry
16 Jan 24
A method of operating a mass spectrometer that allows for high-speed operation is disclosed.
Michael W. Senko, Philip M. Remes
Filed: 30 Jun 22
Utility
Retaining Ring for a Centrifuge
11 Jan 24
A retaining ring arrangement for a centrifuge rotor of a centrifuge, comprising a base, having a planar portion with an aperture centrally therethrough, the base further having a perimeter wall extending upwardly from the planar portion to define a cavity bounded by the planar portion and the perimeter wall.
Benoit Jean LIMON
Filed: 6 Jul 23
Utility
Processing Ion Peak Areas In Mass Spectrometry
11 Jan 24
A method of analysing a signal generated by a mass analyser comprises receiving a signal generated by the mass analyser, determining the area of a first ion peak of one or more ion peaks in the signal, and estimating the number of ions that contributed to the first ion peak.
Bernd Hagedorn, Daniel Mourad, Toby Shanley, Hamish Stewart, Ankit Dwivedi
Filed: 6 Jul 23
Utility
Biotin Derivatives
11 Jan 24
Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.
Lai-Qiang YING, Stephen YUE, Bruce BRANCHAUD, Yu-Zhong ZHANG
Filed: 10 Jul 23
Utility
Cycle Timer for Improved Purity of Reagent Gas Systems
11 Jan 24
A system including a gas source coupled to a mass spectrometer with a supply line to provide reagent gas for chemical ionization; a bypass line connecting the supply line to a foreline of a vacuum pump, the bypass line including a valve and a bypass restrictor; and a cycle timer operable to open the valve for a first period of time and close the valve for a second period of time.
Edward B. McCAULEY
Filed: 15 Jun 23
Design
Saliva collection device
9 Jan 24
Syrus Jaffe, Angie Cheng, Scott Michelhaugh
Filed: 9 Feb 21
Utility
Compositions and methods for enhanced fluorescence
9 Jan 24
This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.
Surbhi Desai, Marie Christine Nlend, Kyle Gee, Matthew Baker, Robert Aggeler, Scott Sweeney, Aleksey Rukavishnikov, Shih-Jung Huang
Filed: 22 May 20
Utility
Acoustically settled liquid-liquid sample purification system and method of use
9 Jan 24
A sample purification system includes a mixing zone; a settling zone in fluid communication with the mixing zone; a mixer element disposed in the mixing zone, the mixer element being configured to mix immiscible liquids to form a mixture; and a first acoustic wave settler configured to emit an acoustic wave into the mixture.
Scott P. Collins, Christopher D. Brau, Nephi D. Jones
Filed: 8 Nov 21
Utility
Polymerase compositions and kits, and methods of using and making the same
9 Jan 24
The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization.
Daniel Mazur, Peter B. Vander Horn, Eileen Tozer, Sihong Chen, Guobin Luo, Joshua Shirley, Kevin Heinemann
Filed: 7 May 21
Utility
Methods and systems for evaluating microsatellite instability status
9 Jan 24
Methods for evaluating microsatellite instability (MSI) analyze nucleic acid sequence reads corresponding to a plurality of marker regions for MSI.
Sameh El-Difrawy
Filed: 11 Jan 23