Thank you, Lisa. Good morning, everyone and thank you for joining us this morning. I'm very excited about the progress we have made this quarter despite the challenges of the global pandemic as we work to develop transformative therapies with the potential to cure blindness diseases.
Our first gene therapy product candidate, OCU400 for retinitis pigmentosa is on track to enter the clinic, it's a two pronged Phase 1-2 trials in the next year.
Our second gene therapy product, OCU410 for dry age-related macular degeneration and our first novel biologic, OCU200 for major retinal diseases are on track to enter the clinic in 2022.
Our business strategy of diversifying our product approaches to ensure portfolio diversification and reduce risk was shown to be prudent. And in June, when we decided to discontinue the Phase 3 trial of OCU300 for ocular graft versus host disease. A pre-planned interim sample site analysis indicated the trial was unlikely to meet its co-primary endpoints upon completion.
As a result, we ceased development of OCU300 and initiated a workforce reduction as a part of our shift in focus towards the modifier gene therapy platform and novel biologics program.
We will add resources where needed in the coming year to further strengthen our R&D and clinical development groups in support of our planned short term and midterm goals of initiating for early stage clinical trials within the next one to two years. We were successful in raising capital through our ATM programs to extend our runway into first quarter of 2021.
We will continue to raise capital to support our short and midterm value creation goals for our patients as well as shareholders. Today, we will provide an update on our progress as we drive our product pipeline forward. Sanjay will then share highlights of our second quarter 2020 financial results before the Q&A.
Our management team and advisors are dedicated to creating long-term value for our shareholders, as evidenced by the appointment of Dr. Mohamed Genead as chair of our Retinal Scientific Advisory Board, we're attracting top talent to drive our product development initiatives forward. Dr. Genead is an ophthalmologist, retinal specialist, and inherited retinal disease expert with over 20 years of experience in ophthalmology and gene and cell therapies. His deep experience in ophthalmology and gene therapy will be instrumental as we advance our breakthrough modifier gene therapy platform into the clinic next year. He's also offering tremendous support to Ocugen as an Acting Chief Medical Officer.
We continue to be really excited about our modified gene therapy platform, which has the potential to treat a variety of inherited retinal diseases with a single gene therapy product.
One of the biggest advantages of our modified gene therapy platform is that it has the potential to eliminate the need for individual gene replacement and gene editing strategies, and may therefore be highly differentiated from traditional gene therapy for eye diseases. Last month, we were granted our third FDA orphan drug designation for OCU400 for the treatment of RHO mutation-associated retinal degenerative diseases. The RHO mutation is part of the retinitis pigmentosa group of rare genetic disorders that involve the breakdown and loss of cells in the retina and can lead to visual impairment and blindness. This is one of the more common mutations within the class, accounting for approximately 12% of retinitis pigmentosa patients in the United States, adding to the orphan drug designations for OCU400 for NR2E3 and CEP290 mutation associated retinal degeneration, the ODD for RHO gene mutation associated retinal degeneration further supports Ocugen's breakthrough modifier gene therapy platform's potential to treat multiple blindness diseases with a single product. This week, we announced receipt of our fourth FDA orphan drug designation for OCU400 and PDE6B, a gene mutation resulting in retinitis pigmentosa and autosomal dominant congenital stationary night blindness, four orphan drug designations for a single gene therapy product. OCU400 is distinct in the ophthalmology space. And we are excited about taking this program into the clinic next year for patients who are in desperate need of rescue from blindness diseases Inherited retinal degenerations such as retinitis pigmentosa affect over 1.5 million people worldwide, over 150 gene mutations have been identified as associated with retinitis pigmentosa and this number represents only 60% of the retinitis pigmentosa patient population. The remaining 40% of these patients cannot be genetically diagnosed, make it difficult to develop individual treatments. We believe our modifier gene therapy has the potential to eliminate the need for developing more than 150 individual products and provide one treatment option for all these patients. This month, our Chief Scientific Officer, Dr. Rasappa Arumugham, will highlight our breakthrough modifier gene therapy platform as a part of the next generation therapy seminar at this year's World Orphan Drug Congress USA Conference on August 24th.
We will also be providing updates at four investor conferences in the U.S. and the gene therapy conference in Europe in September and October.
Our strategic partnership with CanSinoBIO further solidifies our plans to enter the clinic in the next year for the development of OCU400.
Our manufacturing activities are going well and as planned including scaling up to 200 liter batch size for our planned Phase 1-2 trials.
Our applied to scale of manufacturing to commercial levels at this time minimizes the risk of product inconsistency in the future. Product consistency is extremely critical for any gene therapy product.
We are on track with our IND enabling GLP toxicology studies. Overall, we are very happy with the progress on this program and very excited to enter into the clinic next year as planned.
For OCU200, we anticipate a pre-NDA meeting with FDA later this year for this novel biologic for the treatment of major retinal diseases, including diabetic macular edema, diabetic retinopathy, and age related macular degeneration. We're also planning to secure a manufacturing partner soon.
For OCU410, to treat dry age related macular degeneration, we are planning to meet with the FDA during the first half of next year to agree on a roadmap for IND enabling studies and early stage clinical trials.
Before I turn the call over to Sanjay, I just want to mention our continued commitment to our shareholders as we drive the development of our product pipeline and our deep commitment to patients by addressing rare and underserved blindness diseases through gene therapies and novel biologics. I will now turn the call over to Sanjay to provide our second quarter 2020 financial update. Sanjay?