Inhibikase Therapeutics (IKT)

Alex Lobo Stern Investor Relations
Milton Werner Chief Executive Officer
Joseph Frattaroli Chief Financial Officer
Call transcript
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Greetings, welcome to Inhibikase Therapeutics’ First Quarter 2022 Financial Results Conference Call. At this time, all participants are in listen-only mode. A question-and-answer session will follow the formal presentation. [Operator Instructions] Please note this conference is being recorded. I will now turn the conference over to Alex Lobo, Stern Investor Relations. you. Thank

begin. now may You

Alex Lobo

Executive you, XX-Q release press Sherry. for We company's first audio release XX, to Therapeutics first Inhibikase report Werner, first and With Financial the ended Frattaroli, Officer. Yesterday financial Good XXXX financial results XXXX. morning encourage afternoon Chief report Inhibikase’s everyone on on read with Milton quarterly March quarter Dr. at also are and a which today Form well as welcome and press XXXX, results inhibikase.com. yesterday's the Joseph me as quarter quarterly Chief press filed Inhibikase issued is Inhibikase’s quarter to is available Thank website Officer; release announcing being and conference webcast. the The call SEC. for

Participants turn conference XXXX. In is Harbor call be Please the applicable as relations on required information through or section and of the the the Private you events call provisions date there discussed Dr. the Reform webcast differ that company the from note obligation most for with at investor only being uncertainties revise filings cautioned Werner. to company's will undertakes The are public the date company's to these Litigation would those this Safe this potential and Milton, forward after the or as Information XXXX. risks May forward is update forth contains future and pay are by any information could of covered to associated Act call the webcast, reference. of that under this accurate website, set broadcast, With recent certain may looking archived except due no Milton SEC looking or addition, of of our this statements law. to live with that implied sec.gov. I like by is call proceed. said, of statements Actual over time uncertainties sensitive results now Securities risks XX, conference business. that stated to in reflect be securities materially on circumstances today's

Milton Werner

joining And thank quarter Thanks. call. first everyone earnings XXXX to and Alex, Therapeutics’ you Inhibikase for thank you,

As field year, diligently preclinical This investor disease. month, clinical as an educational development we the example, we leading Parkinson's kicked advance in of extend for off to disorders our worked as thought to together host movement have in we programs the leadership and KOLs brought our well event. past

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non-receptor an Kinase is highly our selective program, lead c-Abl inhibitor. IkT-XXXXXX a with So now let me Tyrosine Abelson start IkT-XXXXXX.

accumulate ability to in was profile the Toxicology and barrier and Animal As including, designs. brain. to predictable a to the have XXXXXX, the remember, Studies, these low-toxicity designed have Studies you blood-brain Chronic may confirm cross

subjects or randomized, IkT-XXXXXX that study. trial cohort data dosing The levels evaluating disease. the Phase currently safety assessing The Parkinson's from this The X:X the of is of cohort a we escalating with Pharmacokinetics aggregates and three nervous X system. the escalation of from the extension healthy study. and suggested in of volunteers similar, and tolerability consistent are motility is non-motor In to mild Parkinson's endpoints. and IkT-XXXXXX trial moderately and penetrates the plans Xb and is Conference, patients to dose our safety, at motor across that placebo-controlled older patient and first further seven-day dose tolerability, pharmacology exploratory We and pharmacokinetics profile of and patients central study closely volunteers advanced IkT-XXXXXX also data a presented also, at IkT-XXXXXX as met in is AD/PD measure Alzheimer's from Diseases function alpha-synuclein gut was that the study of Conference. Phase groups March, the in suggesting evaluating

eight expect in of second six to cohort dosed have complete second and patients the in cohort this We the quarter.

and expect medical of year. the disease later present We meeting additional on the the on this from effects data Parkinson's comment to study measures a at

a is of cannot for seven different While small at potential doses. number the blinded, the still draw we any benefit IkT-XXXXXX based trial the dosing days of on about conclusions of patients

a results Phase seven working believe Phase a are same that not IkT-XXXXXX a does of of the the We we far pharmacology dosed our when outcomes, we patient's for advance dubbed study of is to continue that healthy patients treatment support thus Trial in disease XXX and and the age. of Parkinson's, for in Based to on Phase have the therapeutic Xa IkT-XXXXXX potential The and study. as subjects into diligently with yet these The the trial XXX for similar Phase determined days also X disease and randomized, X:X that trial and to worsen that and up to treatment endpoints, will Parkinson's brain Xa Xb hierarchy IkT-XXXXXX non-motor disease-modifying studies end XX-week outside seen diagnosed clinician the IkT-XXXXXX safety a to Parkinson's and symptomatic exploratory doses IkT-XXXXXX points. whether a of have will in that reduction patient leads measure inside the treatment. patients of safety and not three will of tolerability and pathogenic be dosing IkT-XXXXXX clearance or need as evaluate will reported evaluate double-blind function as secondary using of motor who outcomes aggregate alpha-synuclein of the to with progressed

first activating quarter. We and the the are announcing of forward look second sites currently process the in in dosing in to patients clinical

efforts. Turning our now to preclinical

We are programs in work two our leverage advancing that neurodegeneration.

such Myeloid Leukemia. for have Mesylate The first is stable-phase matinib of designed a better Imatinib-sensitive potentially as formulation Chronic cancers, our we IkT-XXXPro, safer, which as tolerated prodrug treatment

studies conducting submission the the are investigational stability IND application for quarter. for submit expect necessary We to submission this drug IND the package and new

study the later the we proceed discussions intend Following it may XXX(b)(X) FDA, the regulatory and commence bioequivalence to pathway. the with with receipt other accordance studies of in

our the multiple work ph for XXXXXX treatment Finally, preclinical atrophy. we evaluating system are potential continuing of

that Union, inhibition have As we expect systems. one to the studies which essential to and you these model autonomic MSA on is disease. benefit evaluating has study of is Similar could two Parkinson's, into fourth to full are slow of of approximately a affects may and to equivalent the of neurons. may currently quarter by These The clinical we dysfunction people halt this nervous effect. and at in model a FDA MSA the movement in subject a therapeutic characterized pathological Xa a whether in MSA that no or from European results the bodies progression remember, therapeutic Phase in one second XXXX. affects models c-Abl Depending study degeneration animal rare, treatments agreement US there studies beneficial XXXXXX approved of and preclinical lead administration XX,XXX may in both and from least neurodegenerative aggregation, with progressive cell advance in and disorder rapidly to alpha-synuclein the regulatory MSA, of data preliminary XXXX. readouts quarter report animal indicates IkT-XXXXXX are

let over to call the Joe? Frattaroli, Now CFO, turn me Joe financials. to review our the

Joseph Frattaroli

Milton. you, Thank

March – our approximately million, XXXX, compared million offset for a in $X.X XXXX. we expenses $X.X development of Let approximately or -- quarter $X.XX per and months Research $X.X of three loss reported research net approximately loss the increase $X.XX were me decrease related of grant for financials XXXX. non-grant-related a $X.X first net for increase first share of research, million million me, million the for of loss XXXX share first per and loss review in to quarter quarter the in excuse increased XXXX. by and increase fees, expenses $X compensation resulting net the the expenses the with The compensation stock to net million research for $X.X trial. first XXXX million ended by for operating of fees, disease and in investor other a board to fees of by increased or Selling, to compared XXXX XX, primarily in million of a approximately driven quarter headcount expense non-grant-related approximately of and of million, expense expenditures company's and for $X.X million period compared Parkinson's a connection decreased primarily non-cash increase non-cash relations was a decrease was of increased million of $X.X were $X.X normal stock-based offset $X.X same Phase general compensation also quarter legal administrative due to for million. The $X.X the net expense. $X.X clinical $X.X approximately expended The consulting X the first in million was

had third back our the of like we our capital hand March for and to Inhibikase of and closing that XXXX, the Milton XX, expenses be approximately to quarter fund remarks. equivalents cash XXXX. $XX.X to sufficient operating existing As in requirements statements. That into and cash concludes expect equivalents, call over expenditure financial will cash I'd million cash

Milton Werner

about significantly our excited as the from quarter suffering diseases. anticipate lives Thank we you, devastating seek neurodegenerative and our remain improve milestones achieving clinical goals We to and second multiple and patients across of Joe. the progress pre-clinical very for programs

call IND to believe efforts conditions, in these MSA to continue tirelessly challenges we quarter. taken the we together, We position for to from the application study questions. drive for To Xa at an on to continue success will and our Phase work study us preclinical all shareholder current now shareholders, submitting your and for And we long-term. on data XXXPro the of report initiate that patient the will by like to improve appreciate expect would value despite Operator? support, program open I least unwavering in this posed our XXXXXX outcomes. market and to

End of Q&A

at [Operator Thank questions Okay. this There Instructions] today's time. no you. will conclude That are conference.

participation. You may for your this at lines you time, and disconnect thank your