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RGEN Repligen

GRANT
Utility
Disposable alternating tangential flow filtration units
26 Oct 21
Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.
Travis R. Ward, Steven R. Pearl, Adam Malone, Tim Erlandson
Filed: 26 Aug 16
GRANT
Utility
Slope spectroscopy standards
12 Oct 21
The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements.
Mark Salerno, I-Tsung Shih, Craig Harrison
Filed: 9 Nov 20
GRANT
Utility
Flexible tubing management system for pharmaceutical, bioprocess applications, and food/dairy applications
7 Sep 21
A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks.
Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
Filed: 18 Feb 20
GRANT
Utility
Methods, devices and systems for 3-stage filtration
8 Jun 21
The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.
Michael Bransby
Filed: 7 May 18
GRANT
Utility
Tangential flow depth filtration systems and methods of filtration using same
1 Jun 21
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 5 Aug 20
GRANT
Utility
Encapsulated valve system and method of use
1 Jun 21
An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface.
Michael C. Gagne, Steven V. Cates
Filed: 5 Feb 19
GRANT
Utility
Alkaline stable Fc-binding proteins for affinity chromatography
25 May 21
The present invention relates to Fc binding proteins comprising one or more Fc binding domains wherein at least one domain comprises of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-6 or 21.
Paul Knick, Erik Fiedler, Ulrich Haupts, Maren Meysing
Filed: 7 Aug 17
GRANT
Utility
Fluid monitoring assembly with replaceable sensor functionality
25 May 21
A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid.
Michael C. Gagne, Steven V. Cates, Dean Richards, Scott Bendon
Filed: 13 Sep 19
GRANT
Utility
Fluid plug for sterile processes and methods of using the same
9 Feb 21
A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed.
Michael C. Gagne
Filed: 3 Aug 16
GRANT
Utility
Slope spectroscopy standards
9 Nov 20
The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements.
Mark Salerno, I-Tsung Shih, Craig Harrison
Filed: 18 Jun 19
GRANT
Utility
Plunger pumping arrangement for a hollow fiber filter
12 Oct 20
A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel.
Rudolf Pavlik
Filed: 27 Dec 17
GRANT
Utility
Dual pumping arrangement for a hollow fiber filter
5 Oct 20
A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel.
Rudolf Pavlik
Filed: 27 Dec 17
GRANT
Utility
Method of actuation of an alternating tangential flow diaphragm pump
14 Sep 20
A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply.
Rudolf Pavlik
Filed: 7 Feb 18
GRANT
Utility
Tangential flow depth filtration systems and methods of filtration using same
7 Sep 20
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 18 Nov 19
GRANT
Utility
Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly
13 Jul 20
A method for promoting biological activity uses a filter system to increase cell production of a fed batch bioreactor.
David Serway
Filed: 10 Apr 16
GRANT
Utility
Sterilizing chromatography columns
6 Apr 20
If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.
James Ronald Peyser, Dana Cristina Pentia
Filed: 15 Jan 15
GRANT
Utility
Tangential flow depth filtration systems and methods of filtration using same
20 Jan 20
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 7 Mar 19
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