196 patents
Page 3 of 10
Utility
System and method for monitoring phase-separation and mutual miscibility of fluid mixtures
14 Mar 23
Exemplary embodiments are directed to methods and systems for controlling fluid parameters within a detector.
Abhijit Tarafder, Sebastien Besner, Mark Basile, Martin Gilar
Filed: 15 Nov 19
Utility
Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
7 Mar 23
The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans.
Matthew A. Lauber, Stephan M. Koza, Pamela C. Iraneta, KEvin D. Wyndham
Filed: 19 Oct 18
Utility
Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography
14 Feb 23
The present invention provides methods for performing supercritical fluid chromatography comprising loading a sample to be separated by supercritical fluid chromatography onto a stationary phase comprising a spherical, monodisperse, core-shell particulate material comprising a nonporous core and one or more layers of a porous shell material surrounding the core, wherein the particles are sized less than 2 microns; and performing supercritical fluid chromatography to separate the sample.
Kevin D. Wyndham, Jacob N. Fairchild, Pamela C. Iraneta, Stephen J. Shiner, Darryl W. Brousmiche, Daniel P. Walsh
Filed: 10 Jun 14
Utility
Aptamer based affinity capture methods for the selective enrichment of human immunoglobulin Fc domains
7 Feb 23
A method of capturing human immunoglobulin Fc domains in a biofluid sample is provided.
Xiaoxiao Liu, Matthew A. Lauber
Filed: 26 Jun 20
Utility
Dual mode sample manager
7 Feb 23
Described is a dual mode sample manager for a liquid chromatography system.
Sylvain Gilles Cormier, Joseph D. Michienzi
Filed: 23 Mar 20
Utility
Sample automation manager
7 Feb 23
A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column.
Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, Jr.
Filed: 23 Mar 21
Utility
Methodology for scaling methods between supercritical fluid chromatography systems
31 Jan 23
A methodology scales supercritical fluid chromatography (SFC) and/or carbon dioxide based chromatography methods between different system and/or column configurations.
Christopher J. Hudalla, Abhijit Tarafder
Filed: 12 Jun 14
Utility
Apparatus for multi-specimen test instrument
24 Jan 23
Described are a test device, a multi-specimen test fixture star and a multi-specimen test fixture.
Jason L. Chinavare
Filed: 13 Dec 19
Utility
Haptic feedback for configuring materials testing systems
17 Jan 23
Disclosed is a material testing system that includes an output shaft configured to be moved by operation of a motor, the output shaft coupleable to a test specimen such that movement of the output shaft imparts a mechanical force on the test specimen.
David L. Dingmann
Filed: 24 Jun 21
Utility
Liquid chromatography thermal system with thermal status detection
17 Jan 23
A liquid chromatography system including a solvent delivery system, a sample delivery system in fluidic communication with solvent delivery system, a liquid chromatography column located downstream from the solvent delivery system and the sample delivery system, a detector located downstream from the liquid chromatography column, a thermal chamber housing at least one of the solvent delivery system, the sample delivery system, the liquid chromatography column and the detector, an engine configured to control the temperature in the thermal chamber, a heatsink operably connected to the engine, a first temperature sensor in the thermal chamber, a second temperature sensor, and a computer system configured to receive temperature information from each of the first and second temperature sensors, and implement a method for controlling temperature in the thermal chamber.
David A. Simpson, Cameron Chaput, Miguel M. Soares
Filed: 19 Jul 19
Utility
Mixer for chromatography system
17 Jan 23
Described is a mixer for a chromatography system.
Peyton C. Beals, Sylvain Gilles Cormier, Richard Wayne Andrews
Filed: 10 Aug 20
Utility
Method and apparatus for minimizing the chromatographic band distortion of a back pressure regulator
17 Jan 23
The technology generally relates to tailoring a back pressure regulator in a chromatographic system to reduce unswept volume within the back pressure regulator to achieve better sample detection and a reduction in chromatographic band distortion effects.
Michael O. Fogwill, Joseph D. Michienzi, Joshua A. Shreve, Scott Kelley, Emily J. Berg
Filed: 13 May 20
Utility
Heat flow rate determination for a single sample differential scanning calorimeter
3 Jan 23
A method and a calorimeter system for reducing error in a measured sample heat flow rate due to interpan heat exchange are described.
Robert L. Danley
Filed: 24 Nov 20
Utility
Methods to increase sensitivity of LC/MS analysis
20 Dec 22
The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy.
Paul Rainville, Kerri Smith
Filed: 15 Jan 21
Utility
Nickel-cobalt alloy material devices and components
29 Nov 22
Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors.
Jonathan L. Belanger, Hua Yang, Edouard S. P. Bouvier, Mathew DeLano, Raymond P. Fisk, Hillary B. Hewitson, Wade P. Leveille, Kevin Daniel Wyndham
Filed: 12 Aug 16
Utility
Rotary valve having bypass state
22 Nov 22
A rotary valve that includes a stator, a rotor and a plurality of sample channels.
Sylvain Gilles Cormier, Charles T. Murphy, Joseph D. Michienzi
Filed: 25 Jan 22
Utility
Variable thickness diaphragm pressure transducer and method
15 Nov 22
A diaphragm pressure transducer includes a body having an outer surface and a diaphragm, a strain gauge including a resistive element located on the outer surface, a fluidic inlet, and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet, the fluidic cavity having an upper surface.
Zongren Shang
Filed: 2 Apr 19
Utility
Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules and small molecules
25 Oct 22
The present disclosure relates to the determination of analytes in a sample using chromatography.
Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion, Melvin Blaze Muttikal Thomas, Thomas Walter
Filed: 14 Apr 20
Utility
Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution
25 Oct 22
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof.
Kevin D. Wyndham, Beatrice W. Muriithi
Filed: 13 Aug 18
Utility
System and method for detecting high pressure seal leaks in chromatographic pumps
18 Oct 22
The present disclosure relates to techniques for detecting leaks in a pump.
Michael O. Fogwill, Jason F. Hill
Filed: 18 Dec 19