AnaptysBio (ANAB)

Imsidolimab, previously known as ANB019, is an antibody that inhibits the function of the interleukin-36-receptor, or IL-36R, which AnaptysBio plans to initially develop as a potential first-in-class therapy for patients suffering from generalized pustular psoriasis, or GPP, EGFR-mediated skin toxicity, ichthyosis, hidradenitis suppurativa and acne.

Company profile

Hamza Suria
Fiscal year end
Former names
AnaptysBio Pty Ltd ...

ANAB stock data

Investment data

Data from SEC filings
Securities sold
Number of investors


8 Aug 22
12 Aug 22
31 Dec 22
Quarter (USD) Jun 22 Mar 22 Dec 21 Sep 21
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Annual (USD) Dec 21 Dec 20 Dec 19 Dec 18
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Cash burn rate (est.) Burn method: Change in cash Burn method: Operating income Burn method: FCF (opex + capex)
Last Q Avg 4Q Last Q Avg 4Q Last Q Avg 4Q
Cash on hand (at last report) 71.7M 71.7M 71.7M 71.7M 71.7M 71.7M
Cash burn (monthly) 31.57M 21.72M 9.27M 8.12M 8.05M 6.46M
Cash used (since last report) 45.81M 31.51M 13.45M 11.79M 11.68M 9.37M
Cash remaining 25.89M 40.19M 58.26M 59.92M 60.02M 62.33M
Runway (months of cash) 0.8 1.9 6.3 7.4 7.5 9.7

Beta Read what these cash burn values mean

Date Owner Security Transaction Code Indirect 10b5-1 $Price #Shares $Value #Remaining
8 Aug 22 Loumeau Eric J Common Stock Sell Dispose S No Yes 25 523 13.08K 0
23 Jun 22 Lizzul Paul F. Stock Option Common Stock Grant Acquire A No No 29.7 10,000 297K 10,000
23 Jun 22 Loumeau Eric J Stock Option Common Stock Grant Acquire A No No 29.7 10,000 297K 10,000
23 Jun 22 Mulroy Dennis Stock Option Common Stock Grant Acquire A No No 29.7 10,000 297K 10,000
8 Jun 22 Loumeau Eric J Common Stock Sell Dispose S No Yes 24 2,500 60K 523
8 Jun 22 Loumeau Eric J Common Stock Option exercise Acquire M No No 14.02 2,500 35.05K 3,023
8 Jun 22 Loumeau Eric J Employee Stock Option Common Stock Option exercise Dispose M No No 14.02 2,500 35.05K 83,000
13F holders Current Prev Q Change
Total holders 135 141 -4.3%
Opened positions 18 26 -30.8%
Closed positions 24 15 +60.0%
Increased positions 33 38 -13.2%
Reduced positions 52 42 +23.8%
13F shares Current Prev Q Change
Total value 957.09M 1.48B -35.2%
Total shares 40.42M 38.43M +5.2%
Total puts 0 0
Total calls 9.6K 24.1K -60.2%
Total put/call ratio
Largest owners Shares Value Change
EcoR1 Capital 7.52M $186.07M 0.0%
EcoR1 Capital Fund 7.15M $139.53M 0.0%
Tang Capital Partners 2.63M $56.52M 0.0%
Tang Capital Management 2.63M $65.03M 0.0%
Vanguard 1.83M $45.21M -0.8%
BLK Blackrock 1.82M $45.11M -2.2%
FHI Federated Hermes 1.6M $39.66M -0.1%
Point72 Asset Management 1.32M $32.6M +412.4%
Boxer Capital 1.3M $32.16M 0.0%
STT State Street 958.1K $23.7M +9.8%
Largest transactions Shares Bought/sold Change
Point72 Asset Management 1.32M +1.06M +412.4%
Frazier Life Sciences Management 899.7K +899.7K NEW
Frazier Management 0 -899.7K EXIT
Deep Track Capital 558.78K +558.78K NEW
Logos Global Management 300K +300K NEW
Woodline Partners 833.93K +223.95K +36.7%
FMR 178.92K +156.96K +714.7%
Natixis 16.3K -142.7K -89.7%
Great Point Partners 700K +107.75K +18.2%
Dimensional Fund Advisors 891.85K +88.46K +11.0%

Financial report summary

PfizerAMGENXOMAIncyteAstrazenecaRocheNovartisSanofiLyra TherapeuticsAbbvie
  • Risks Related to Discovery and Development of Our Product Candidates
  • Our product candidates are in early stages of development and may fail in development or suffer delays that adversely affect their commercial viability. Results from our initial clinical trials may not be representative of the results we will experience in later clinical trials. If we or our collaborators are unable to complete development of or commercialize our product candidates or experience significant delays in doing so, our business will be materially harmed.
  • We have only limited data regarding the safety profile of our wholly-owned product candidates when dosed in humans. Our ongoing and planned clinical trials or those of our collaborators may reveal significant adverse events, toxicities or other side effects and may result in a safety profile that could inhibit regulatory approval or market acceptance of any of our product candidates.
  • We and/or our collaborators may be unable to obtain, or may be delayed in obtaining, required regulatory approvals in the United States or in foreign jurisdictions, which would materially impair our ability to commercialize and generate revenue from our product candidates.
  • We may not be successful in our efforts to use our technology platform to expand our pipeline of product candidates and develop marketable products.
  • We have recently commenced clinical development of imsidolimab, rosnilimab and ANB032 and no history of commercializing biotechnology products, which may make it difficult to evaluate the prospects for our future viability.
  • We face significant competition, and if our competitors develop and market products that are more effective, safer or less expensive than our product candidates, our commercial opportunities will be negatively impacted.
  • Our product candidates may not achieve adequate market acceptance among physicians, patients, health care payors and others in the medical community necessary for commercial success.
  • If companion diagnostics for our product candidates, for which such diagnostics are required, are not successfully, and in a timely manner, validated, developed or approved, we may not achieve marketing approval or realize the full commercial potential of our product candidates.
  • The manufacture of biologics is complex, and our third-party manufacturers may encounter difficulties in production. If any of our third-party manufacturers encounter such difficulties, our ability to provide supply of our product candidates for clinical trials, our ability to obtain marketing approval, or our ability to provide supply of our products for patients, if approved, could be delayed or stopped.
  • Risks Related to Our Financial Position and Capital Needs
  • We have limited operating revenue and a history of operational losses and may not achieve or sustain profitability. We have no products approved for commercial sale, and to date we have not generated any revenue or profit from sales of our product candidates.
  • We will require additional capital to finance our operations, which may not be available to us on acceptable terms, or at all. As a result, we may not complete the development and commercialization of our product candidates or develop new product candidates.
  • Raising additional capital may cause dilution to our existing stockholders, restrict our operations or require us to relinquish rights to our product candidates on unfavorable terms to us.
  • Risks Related to Managing Growth, Operations and Macroeconomic Conditions
  • We must attract and retain highly skilled employees in order to succeed.
  • We currently have no marketing and sales force. If we are unable to establish effective sales or marketing capabilities or enter into agreements with third parties to sell or market our product candidates, we may not be able to effectively sell or market our product candidates, if approved, or generate product revenue.
  • We expect to expand our development and regulatory capabilities, and as a result, we may encounter difficulties in managing our growth, which could disrupt our operations.
  • We may be vulnerable to disruption, damage and financial obligation as a result of system failures.
  • Our operations, or the third parties upon whom we depend, are vulnerable to interruption by fire, earthquake, power loss, telecommunications failure, terrorist activity, health epidemics or pandemics and other events beyond our control, which could harm our business.
  • Risks Related to Our Dependence on Third Parties
  • Our existing collaboration with GSK is important to our business, and future collaborations may also be important to us. If we are unable to maintain this collaboration, or if this collaboration is not successful, our business could be adversely affected.
  • We may not succeed in establishing and maintaining additional development and commercialization collaborations, which could adversely affect our ability to develop and commercialize product candidates.
  • If third parties on which we depend to conduct our planned preclinical studies and clinical trials do not perform as contractually required, fail to satisfy regulatory or legal requirements or miss expected deadlines, our development program could be delayed with adverse effects on our business, financial condition, results of operations and prospects.
  • We rely completely on third parties to manufacture our nonclinical, clinical and future commercial drug supplies of any approved products.
  • We depend on a small number of suppliers for the raw materials necessary to produce our product candidates. The loss of these suppliers, or their failure to supply us with these raw materials, would materially and adversely affect our business.
  • Risks Related to Regulatory Approval of Our Product Candidates and Other Legal Compliance Matters
  • Even if our product candidates receive regulatory approval, they will be subject to significant post-marketing regulatory requirements.
  • Our failure to obtain regulatory approval in international jurisdictions would prevent us from marketing our product candidates outside the United States.
  • We may not be able to maintain, for imsidolimab in GPP, or obtain, for other indications with imsidolimab or for certain of our other product candidates, Orphan Drug Designation or obtain the benefits associated with Orphan Drug status, including market exclusivity.
  • Any drugs we develop may become subject to unfavorable third-party reimbursement practices and pricing regulations.
  • Healthcare legislative reform measures may increase the difficulty and cost for us to obtain marketing approval of and commercialize our product candidates and affect the prices we may obtain.
  • Our business entails a significant risk of product liability, and our ability to obtain sufficient insurance coverage could have an adverse effect on our business, financial condition, results of operations or prospects.
  • Our relationships with customers and third-party payors will be subject to applicable anti-kickback, fraud and abuse, transparency and other health care laws and regulations, which could expose us to, among other things, criminal sanctions, civil penalties, contractual damages, reputational harm, administrative burdens and diminished profits and future earnings.
  • Our employees may engage in misconduct or other improper activities, including noncompliance with regulatory standards and requirements and insider trading.
  • Risks Related to Intellectual Property
  • If we are unable to obtain or protect intellectual property rights, we may not be able to compete effectively in our market.
  • We may not be able to protect our intellectual property rights throughout the world.
  • Changes in patent law could diminish the value of patents in general, thereby impairing our ability to protect our product candidates.
  • Obtaining and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment, and other requirements imposed by governmental patent agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.
  • Our reliance on third parties requires us to share our trade secrets, which increases the possibility that a competitor will discover them or that our trade secrets will be misappropriated or disclosed.
  • We may become involved in lawsuits to protect or enforce our intellectual property, which could be expensive, time-consuming and unsuccessful and have an adverse effect on the success of our business.
  • If we breach the license agreements related to our product candidates, we could lose the ability to continue the development and commercialization of our product candidates.
  • Third parties may initiate legal proceedings against us alleging that we infringe their intellectual property rights, or we may initiate legal proceedings against third parties to challenge the validity or scope of intellectual property rights controlled by third parties, the outcome of which would be uncertain and could have an adverse effect on the success of our business.
  • We may be subject to claims by third parties asserting that our employees or we have misappropriated their intellectual property or claiming ownership of what we regard as our own intellectual property.
  • Our inability to protect our confidential information and trade secrets would harm our business and competitive position.
  • If we do not obtain protection under the Hatch-Waxman Amendments and similar foreign legislation for extending the term of patents covering each of our product candidates, our business may be harmed.
  • Risks Related to Ownership of Our Common Stock
  • The market price of our stock has been and may continue to be volatile, and you could lose all or part of your investment.
  • We have broad discretion in the use of the net proceeds from our public offerings and may not use them effectively.
  • We may be subject to securities litigation, which is expensive and could divert management attention.
  • The requirements of being a public company may strain our resources, divert management’s attention, and affect our ability to attract and retain additional executive management and qualified board members.
  • Future sales and issuances of our common stock or rights to purchase common stock, including pursuant to our equity incentive plans, could result in additional dilution of the percentage ownership of our stockholders and could cause our stock price to fall.
  • Our disclosure controls and procedures may not prevent or detect all errors or acts of fraud.
  • We do not intend to pay dividends on our common stock, so any returns will be limited to the value of our stock.
  • Provisions in our restated certificate of incorporation and restated bylaws and Delaware law might discourage, delay or prevent a change in control of our company or changes in our management and, therefore, depress the market price of our common stock.
  • If securities or industry analysts do not publish research or reports about our business, or if they issue an adverse or misleading opinion regarding our stock, our stock price and trading volume could decline.
  • We plan to use potential future operating losses and our federal and state net operating loss (“NOL”) carryforwards to offset taxable income from revenue generated from operations or corporate collaborations. However, our ability to use NOL carryforwards could be limited as a result of additional issuances of equity securities.
  • We are a smaller reporting company and may elect to comply with reduced public company reporting requirements applicable to smaller reporting companies, which could make our common stock less attractive to investors.
Management Discussion
  • Collaboration revenue was $63.2 million compared to $75.0 million for the years ended December 31, 2021 and 2020, respectively. A comparison of collaboration revenue is as follows:
  • Collaboration revenue during the year ended December 31, 2021 decreased $11.8 million compared to the year ended December 31, 2020 primarily due to the payment received related to an amendment to the GSK Agreement during 2020, royalty revenue recognized during 2021 and the timing of milestones achieved.
  • We expect that any collaboration revenue we generate will continue to fluctuate from period to period as a result of the timing and amount of milestones from our existing collaborations.

Content analysis

H.S. junior Avg
New words: Boeringer, certainty, exit, monoclonal, month, sponsor, transposed
Removed: adding, artificially, began, Brexit, canceling, complaint, delaying, deliver, derivative, dismissal, distancing, elongation, enrichment, epidemic, experiencing, fiduciary, fluid, half, ill, incapacitated, inflated, magnitude, necessitate, necessitated, plaintiff, preventative, productivity, protective, purporting, putative, reaction, renewed, reopened, rule, shareholder, social, Southern, suspended, suspending, threat, unjust, unspecified, updated, waste, wellbeing, workforce, workplace