Gritstone Bio (GRTS)

Gritstone Oncology, Inc., a clinical-stage biotechnology company, is developing the next generation of immunotherapies against multiple cancer types and infectious diseases. Gritstone develops its products by leveraging two key pillars-first, a proprietary machine learning-based platform, Gritstone EDGETM, which is designed to predict antigens that are presented on the surface of cells, such as tumor or virally-infected cells, that can be seen by the immune system; and, second, the ability to develop and manufacture potent immunotherapies utilizing these antigens to potentially drive the patient's immune system to specifically attack and destroy disease-causing cells. The company's lead oncology programs include an individualized neoantigen-based immunotherapy, GRANITE, and an 'off-the-shelf' shared neoantigen-based immunotherapy, SLATE, which are being evaluated in clinical studies. The company also has a bispecific antibody (BiSAb) program for solid tumors in lead optimization. Within its infectious disease pipeline, Gritstone is advancing CORAL, a COVID-19 program to develop a second-generation vaccine, with support from departments within the National Institutes of Health (NIH), the Bill & Melinda Gates Foundation, as well as a license agreement with La Jolla Institute for Immunology. Additionally, the company has a global collaboration for the development of a therapeutic HIV vaccine with Gilead Sciences.

Company profile

GRTS stock data

Analyst ratings and price targets

Last 3 months

Investment data

Data from SEC filings
Securities sold
Number of investors


4 Aug 22
1 Oct 22
31 Dec 22
Quarter (USD) Jun 22 Mar 22 Dec 21 Sep 21
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Annual (USD) Dec 21 Dec 20 Dec 19 Dec 18
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS
Cash burn rate (est.) Burn method: Change in cash Burn method: Operating income Burn method: FCF (opex + capex)
Last Q Avg 4Q Last Q Avg 4Q Last Q Avg 4Q
Cash on hand (at last report) 80.3M 80.3M 80.3M 80.3M 80.3M 80.3M
Cash burn (monthly) 1.18M (no burn) 9.89M 9.71M 8.78M 8.2M
Cash used (since last report) 3.62M n/a 30.25M 29.71M 26.85M 25.09M
Cash remaining 76.68M n/a 50.05M 50.58M 53.44M 55.2M
Runway (months of cash) 64.8 n/a 5.1 5.2 6.1 6.7

Beta Read what these cash burn values mean

Date Owner Security Transaction Code Indirect 10b5-1 $Price #Shares $Value #Remaining
12 Aug 22 Lawrence Corey Stock Option Common Stock Grant Acquire A No No 4.1 38,000 155.8K 38,000
17 Jun 22 Agarwal Shefali Stock Option Common Stock Grant Acquire A No No 2.22 19,000 42.18K 19,000
17 Jun 22 Clare Fisher Stock Option Common Stock Grant Acquire A No No 2.22 8,693 19.3K 8,693
17 Jun 22 Heyman Richard A. Stock Option Common Stock Grant Acquire A No No 2.22 19,000 42.18K 19,000
13F holders Current Prev Q Change
Total holders 90 121 -25.6%
Opened positions 19 27 -29.6%
Closed positions 50 24 +108.3%
Increased positions 15 38 -60.5%
Reduced positions 39 35 +11.4%
13F shares Current Prev Q Change
Total value 193.62M 265.13M -27.0%
Total shares 42.71M 47.51M -10.1%
Total puts 125.1K 378.7K -67.0%
Total calls 128.3K 267.2K -52.0%
Total put/call ratio 1.0 1.4 -31.2%
Largest owners Shares Value Change
Redmile 6.95M $16.83M +1.2%
Frazier Life Sciences Management 5.24M $12.67M 0.0%
Frazier Life Sciences Public Fund 3.64M $41.82M 0.0%
Versant Venture Management 3.56M $8.62M 0.0%
Vanguard 2.92M $7.07M +6.8%
Versant Venture Capital V 2.9M $37.24M 0.0%
Palo Alto Investors 2.33M $5.64M 0.0%
BLK Blackrock 1.91M $4.63M -50.8%
Deep Track Capital 1.72M $4.16M -42.4%
MS Morgan Stanley 1.29M $3.12M +562.6%
Largest transactions Shares Bought/sold Change
BLK Blackrock 1.91M -1.98M -50.8%
Deep Track Capital 1.72M -1.27M -42.4%
MS Morgan Stanley 1.29M +1.09M +562.6%
Assenagon Asset Management 991.47K +991.47K NEW
Nuveen Asset Management 0 -760.99K EXIT
STT State Street 257.83K -712.15K -73.4%
Avidity Partners Management 0 -560K EXIT
Renaissance Technologies 504.87K +504.87K NEW
Millennium Management 1.09M +488.92K +81.1%
FMR 592.61K +453.3K +325.4%

Financial report summary


Content analysis

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